Results 91 to 100 of about 137,298 (354)

The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction

Investigative Ophthalmology and Visual Science, 2016
Purpose To investigate the expression of humanin (HN) in human retinal pigment epithelial (hRPE) cells and its effect on oxidative stress–induced cell death, mitochondrial bioenergetics, and senescence.
P. Sreekumar, K. Ishikawa, C. Spee, H. Mehta, J. Wan, K. Yen, P. Cohen, R. Kannan, D. Hinton   +8 more
semanticscholar   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Customized strategies for high-yield purification of retinal pigment epithelial cells differentiated from different stem cell sources

Scientific Reports, 2022
Retinal pigment epithelial (RPE) cell dysfunction and death are characteristics of age-related macular degeneration. A promising therapeutic option is RPE cell transplantation.
Kakkad Regha, Mayuri Bhargava, Abdurrahmaan Al-Mubaarak, Chou Chai, Bhav Harshad Parikh, Zengping Liu, Claudine See Wei Wong, Walter Hunziker, Kah Leong Lim, Xinyi Su   +9 more
doaj   +1 more source

Cadherins in the retinal pigment epithelium (RPE) revisited: P-cadherin is the highly dominant cadherin expressed in human and mouse RPE in vivo

PLoS ONE, 2018
The retinal pigment epithelium (RPE) supports the health and function of retinal photoreceptors and is essential for normal vision. RPE cells are post-mitotic, terminally differentiated, and polarized epithelial cells. In pathological conditions, however,
Xue Yang, Jin-Yong Chung, U. Rai, N. Esumi   +3 more
semanticscholar   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

How the Training Environment Affect the RPE during Aerobic Exercise?

, 2008
departmental bulletin ...
岡本, 敦, オカモト, アツシ, Okamoto, Atsushi   +2 more
core   +1 more source

Differentiation/Purification Protocol for Retinal Pigment Epithelium from Mouse Induced Pluripotent Stem Cells as a Research Tool. [PDF]

PLoS ONE, 2016
To establish a novel protocol for differentiation of retinal pigment epithelium (RPE) with high purity from mouse induced pluripotent stem cells (iPSC).Retinal progenitor cells were differentiated from mouse iPSC, and RPE differentiation was then ...
Yuko Iwasaki, Sunao Sugita, Michiko Mandai, Shigenobu Yonemura, Akishi Onishi, Shin-Ichiro Ito, Manabu Mochizuki, Kyoko Ohno-Matsui, Masayo Takahashi   +8 more
doaj   +1 more source

Zebrafish inversin mutants develop scoliosis in the absence of laterality defects

Developmental Dynamics, EarlyView.
Abstract Background Human mutations in INVERSIN are associated with nephronophthisis, variable penetrance of situs inversus and congenital heart disease. Inversin has been shown to localize to cilia and many of the patient phenotypes are attributed to disrupted cilia function.
Christopher J. Derrick, Lorraine Eley, Deborah J. Henderson, Bill Chaudhry   +3 more
wiley   +1 more source

RPE cranks it up a Notch [PDF]

Science, 2017
Neurodevelopment Notch signaling within and between cells is involved in many processes, including cell fate specification. In the retina, high levels of Notch during retinal progenitor cell (RPC) division promote RPC renewal, whereas low levels promote postmitotic neuron differentiation. Ha et al.
openaire   +2 more sources

Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization

Stem cell research & therapeutics, 2017
Dysfunction of the retinal pigment epithelium (RPE) is implicated in numerous forms of retinal degeneration. The readily accessible environment of the eye makes it particularly suitable for the transplantation of RPE cells, which can now be derived from ...
Roni A. Hazim, Saravanan Karumbayaram, Mei Jiang, A. Dimashkie, V. Lopes, Douran Li, B. L. Burgess, P. Vijayaraj, Jackelyn A. Alva-Ornelas, J. Zack, D. Kohn, B. Gomperts, A. Pyle, W. Lowry, David S. Williams   +14 more
semanticscholar   +1 more source