Results 111 to 120 of about 77,663 (265)

Proliferative vitreoretinopathy: An integrative, multi‐pathway perspective on pathogenesis and therapy

open access: yesActa Ophthalmologica, EarlyView.
Abstract Proliferative vitreoretinopathy (PVR) remains the principal biological cause of failed retinal detachment repair. Classical pathogenic models centred on retinal pigment epithelium (RPE) dispersion, retinal injury responses or compartment‐restricted mechanisms do not fully explain the heterogeneity, biomechanical behaviour and clinical ...
Koen A. van Overdam, J. Sebag
wiley   +1 more source

Clinical and molecular features of PRCD‐associated retinopathy

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose To describe the clinical and genetic characteristics of patients with biallelic disease‐causing variants in the PRCD (Progressive Rod‐Cone Degeneration) gene. Methods Multicentre, retrospective cohort study of 19 patients from 13 families across nine reference centres in six countries.
Vasil Kostin   +30 more
wiley   +1 more source

Concurrent macular neovascularization in shallow irregular retinal pigment epithelium elevation phenotypes in age‐related macular degeneration and chronic central serous chorioretinopathy: A systematic review and meta‐analysis

open access: yesActa Ophthalmologica, EarlyView.
Abstract This systematic review and meta‐analysis synthesized the reported frequency of concurrent macular neovascularization (MNV) among selected eyes with author‐defined shallow irregular retinal pigment epithelium (RPE) elevations in age‐related macular degeneration (AMD) and chronic central serous chorioretinopathy (CSC).
Mehmet Cem Sabaner   +7 more
wiley   +1 more source

Regional growth kinetics of geographic atrophy in age‐related macular degeneration with and without fovea‐sparing

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose Fovea‐sparing geographic atrophy (GA) patients retain near‐normal central vision. To better understand GA progression in relation to the fovea, we performed a semi‐automated image analysis of regional atrophy growth in a long‐term GA natural‐history cohort. Methods Prospective‐observational, single‐centre‐study (02/2013–07/2025) at the
Daniel R. Muth   +8 more
wiley   +1 more source

Nearly doubled incidence of surgically treated primary rhegmatogenous retinal detachment in Southern Sweden, 2011–2025

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose To determine the incidence of surgically treated primary rhegmatogenous retinal detachment (RRD) in Southern Sweden between 2011 and 2025, and to examine whether demographic change or risk factor trends account for any change in incidence.
Pernilla Rosenquist, Joakim Thylefors
wiley   +1 more source

Insulin usage and glaucoma treatment associated with the incidence of surgically treated vision‐threatening epiretinal membrane: Evidence from an epidemiological study

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose Multiple factors play a role in epiretinal membrane (ERM) formation and appear to affect the risk of ERM surgery. We explored whether the use of common systemic and topical medications is associated with ERM surgery in Finland. Methods The main outcome variable was incidence of surgically treated vision‐threatening epiretinal membrane (
Sirpa Loukovaara, Jari Haukka
wiley   +1 more source

Maternal Circadian Preference is Associated With Cardiorespiratory Fitness and Participation in Structured Prenatal Exercise

open access: yesBirth, EarlyView.
Maternal circadian preference was associated with cardiorespiratory fitness and participation in structured prenatal exercise. Evening‐oriented women had lower fitness and exercise compliance than morning‐oriented women. Exploratory analyses also identified differences in longitudinal HDL cholesterol trajectories, highlighting the need for further ...
Richard Suminski   +9 more
wiley   +1 more source

Structural and biochemical basis for retinol‐binding protein 4 antagonism by tinlarebant

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Retinol‐binding protein 4 (RBP4) is a member of the lipocalin superfamily that is connected to disease states such as insulin resistance, fatty liver disease and ocular disorders including Stargardt disease. Several retinoid and non‐retinoid antagonists of this protein have been developed for potential clinical use, but none have
Marco Bassetto, Philip D. Kiser
wiley   +1 more source

Evaluation of the Safety and Therapeutic Range of Nanosecond Laser Treatment in Rabbits

open access: yesClinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Subthreshold, nanosecond laser therapy has potential as a treatment for age‐related macular degeneration; however, the therapeutic range and safety profile have not been fully documented. In this study, rabbits were used for a preclinical assessment of nanosecond laser treatment.
Glyn Chidlow   +3 more
wiley   +1 more source

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