Results 161 to 170 of about 14,100 (262)

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, Volume 13, Issue 8, Page 1686-1696, August 2026.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Upper-Body Neuromechanical Coordination Strategies During Fatiguing Sustained Dead Hangs in Climbers. [PDF]

Eur J Sport Sci
Exel J, Kaufmann P, Froschauer O, Baca A, Kainz H, Mochizuki L.   +5 more
europepmc   +1 more source

Modeling Light‐Induced Synaptic Behavior and Visual Memory of Azopolymeric Compounds

Advanced Optical Materials, Volume 14, Issue 29, 7 August 2026.
In the framework of neuromorphic hardware it is essential to predict the evolution of the internal state of the devices mimicking synaptic functionalities to perform in‐silico modeling of specific computational tasks. Here, we provide a rate‐balance equation model to describe the synaptic‐like response of light‐actuated azopolymeric compounds and ...
Mateo Rosero‐Realpe, Federico Ferrarese Lupi, Gianluca Milano, Angelo Angelini   +3 more
wiley   +1 more source

Heterogeneous Folding Intermediates Govern the Conformational Pathway of the RNA Recognition Motif Domain of the Ewing Sarcoma Protein. [PDF]

Biomolecules
Kataria P, Chaudhary V, Mishra CB, Kumar V, Sharma RD, Prakash A.   +5 more
europepmc   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, Volume 13, Issue 44, 7 August 2026.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Translation and Adaptation of the Child and Youth Resilience Measure-Revised and Rugged Resilience Measure: A Mixed-Method Study Among Adolescents in Nepal. [PDF]

Child Psychiatry Hum Dev
Singh R, Chua KC, Pant SB, Paudel R, Gautam K, Luitel NP, Garman E, Eleftheriou G, Wahid SS, Kohrt BA, Jefferies P, Jordans MJD, Lund C.   +12 more
europepmc   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, Volume 13, Issue 43, 3 August 2026.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Distinct genetic profiles influence body mass index between infancy and adolescence. [PDF]

Nat Commun
Wang G, McEwan S, Zeng J, Haile-Mariam M, Yengo L, Goddard ME, Kemper KE, Warrington NM.   +7 more
europepmc   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, Volume 13, Issue 43, 3 August 2026.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

Testosterone administration partially modulates gut microbiota responses to severe energy deficit. [PDF]

Am J Physiol Endocrinol Metab
Mohr AE, Berryman CE, Harris MN, Lawrence AB, Chakraborty N, Campbell R, Dimitrov GI, Gautam A, Hammamieh R, Lieberman HR, Rood JC, Pasiakos SM, Karl JP.   +12 more
europepmc   +1 more source