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Glucocorticoid regulation of rRNA synthesis
Molecular and Cellular Biochemistry, 1991Glucocorticoids inhibit transcription of the genes encoding rRNA (rDNA) in P1798 lymphoma cells. This is due to a decrease in the amount or activity of a transcription factor, called TFIC. TFIC has been purified to apparent homogeneity and the properties of this protein have been investigated in detail. TFIC is tightly associated with RNA polymerase I.
P B, Mahajan, E A, Thompson
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rRNA modifications and ribosome function
Trends in Biochemical Sciences, 2002The development of three-dimensional maps of the modified nucleotides in the ribosomes of Escherichia coli and yeast has revealed that most (approximately 95% in E. coli and 60% in yeast) occur in functionally important regions. These include the peptidyl transferase centre, the A, P and E sites of tRNA- and mRNA binding, the polypeptide exit tunnel ...
Wayne A, Decatur, Maurille J, Fournier
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Alternating polarity in rRNA genes
Cell Biology International Reports, 1978Spread nucleolar material from A. exigua exhibits an unusual arrangement of rDNA cistrons. The cistrons form head-to-head "diamond-shaped" doublets with a short spacer separating the members of the doublet. Single cistrons are usually terminal and arrange tail-to-tail with the adjacent doublet, suggesting the possibility of a repeating unit with a tail-
S, Berger +5 more
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Evolution of rRNA and origin of mitochondria
Nature, 1981The origin of mitochondria has remained a matter of discussion and speculation since Altmann first proposed the endosymbiont hypothesis in 18901. Mitochondria may have arisen by the invasion of aerobic2,3 or anaerobic photosynthetic4 bacteria into ancestral protokaryotic cells, or in a non-symbiotic fashion by compartmentalization of episomal DNA5,6 ...
H, Küntzel, H G, Köchel
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Thermodynamics of aminoglycoside–rRNA recognition
Biopolymers, 2003Abstract2‐Deoxystreptamine (2‐DOS) aminoglycosides are a family of structurally related broad‐spectrum antibiotics that are used widely in the treatment of infections caused by aerobic Gram‐negative bacilli. Their antibiotic activities are ascribed to their abilities to bind a highly conserved A site in the 16 S rRNA of the 30 S ribosomal subunit and ...
Daniel S, Pilch +3 more
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Molecular Biology Reports, 1996
RNase MRP is a ribonucleoprotein enzyme with a structure similar to RNase P. It is required for normal processing of precursor rRNA, cleaving it in the Internal Transcribed Spacer 1.
L, Lindahl, J M, Zengel
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RNase MRP is a ribonucleoprotein enzyme with a structure similar to RNase P. It is required for normal processing of precursor rRNA, cleaving it in the Internal Transcribed Spacer 1.
L, Lindahl, J M, Zengel
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An rRNA variant to deal with stress
Nature Microbiology, 2019Bacteria have previously been assumed to cope with environmental stress by tuning their total number of active ribosomes. Instead, a study in this issue of Nature Microbiology shows that from a heterogeneous pool of ribosomes, Vibrio vulnificus uses ribosomes with a particular ribosomal RNA variant to translate upregulated stress response mRNAs.
Kathrin, Leppek, Maria, Barna
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Guiding ribose methylation of rRNA
Trends in Biochemical Sciences, 1997Eukaryotic rRNAs contain a complex set of ribose-methylated nucleotides. Why are these nucleotides modified and how are they selected? A large family of small nucleolar RNAs (snoRNAs) with long complementarities to sites of rRNA methylation has been recently found to guide such modifications, opening up a direct approach to the study of their elusive ...
J P, Bachellerie, J, Cavaillé
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