Results 11 to 20 of about 110,334 (168)

Novel biomimetic Prussian blue nanocubes-based biosensor for Tau-441 protein detection.

Journal of Pharmaceutical and Biomedical Analysis, 2023
Tau protein is a promising biomarker for early diagnosis of Alzheimer's disease. Therefore, there is an urgent need to develop a simple and effective method for its detection.
Amira ben Hassine, Noureddine Raouafi, F. Moreira   +2 more
semanticscholar   +1 more source

Magnetic Fields Reduce Apoptosis by Suppressing Phase Separation of Tau-441

Research, 2023
The biological effects of magnetic fields (MFs) have been a controversial issue. Fortunately, in recent years, there has been increasing evidence that MFs do affect biological systems. However, the physical mechanism remains unclear.
Wenzhang Lin, Wen-pu Shi, Wanbing Ge, Liang‐Liang Chen, Wei‐Hong Guo, P. Shang, Dachuan Yin   +6 more
semanticscholar   +1 more source

Targeted Expression of Retinoschisin by Retinal Bipolar Cells in XLRS Promotes Resolution of Retinoschisis Cysts Sans RS1 From Photoreceptors

Investigative Ophthalmology and Visual Science, 2022
Purpose Loss of retinoschisin (RS1) function underlies X-linked retinoschisis (XLRS) pathology. In the retina, both photoreceptor inner segments and bipolar cells express RS1. However, the loss of RS1 function causes schisis primarily in the inner retina.
C. Vijayasarathy, Yong Zeng, D. Marangoni, Lijin Dong, Z. Pan, E. Simpson, R. Fariss, P. Sieving   +7 more
semanticscholar   +1 more source

AAV2/4-RS1 gene therapy in the retinoschisin knockout mouse model of X-linked retinoschisis

PLoS ONE, 2022
Objective To evaluate efficacy of a novel adeno-associated virus (AAV) vector, AAV2/4-RS1, for retinal rescue in the retinoschisin knockout (Rs1-KO) mouse model of X-linked retinoschisis (XLRS).
Brittni A Scruggs, Sajag Bhattarai, Megan Helms, Ioana Cherascu, Adisa Salesevic, Elliot Stalter, Joseph G. Laird, Sheila A. Baker, A. Drack   +8 more
semanticscholar   +1 more source

Immune function in X-linked retinoschisis (XLRS) subjects in an AAV8-RS1 Phase I/IIa gene therapy trial.

Molecular Therapy, 2021
This study explored systemic immune changes in 11 subjects with X-linked retinoschisis (XLRS) in a Phase I/IIa AAV8-RS1 gene therapy trial (www.ClinicalTrials.gov NCT02317887).
Alaknanda Mishra, C. Vijayasarathy, C. Cukras, H. Wiley, H. Sen, Yong Zeng, L. Wei, P. Sieving   +7 more
semanticscholar   +1 more source

Rs1h-/y exon 3-del rat model of X-linked retinoschisis with early onset and rapid phenotype is rescued by RS1 supplementation

Gene Therapy, 2021
Animal models of X-linked juvenile retinoschisis (XLRS) are valuable tools for understanding basic biochemical function of retinoschisin (RS1) protein and to investigate outcomes of preclinical efficacy and toxicity studies.
Yong Zeng, H. Qian, M. Campos, Yichao Li, C. Vijayasarathy, P. Sieving   +5 more
semanticscholar   +1 more source

Biomedical potential of Anabaena variabilis NCCU-441 based Selenium nanoparticles and their comparison with commercial nanoparticles

Scientific Reports, 2021
Selenium nanoparticles (SeNPs) are gaining importance in the field of medicines due to their high surface area and unique properties than their other forms of selenium.
Bushra Afzal, Durdana Yasin, Haleema Naaz, Neha Sami, Almaz Zaki, M. Rizvi, Raj Kumar, P. Srivastava, T. Fatma   +8 more
semanticscholar   +1 more source

Extraction and Detection of Some Flavonoids from Tamarix aphylla (F. Tamaricaceae) Grown in Iraq

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022
Objective: In the present study, screening for some flavonoids (aglycone and glycoside) in tamarix aphylla by using thin layer chromatography and high-performance liquid chromat-ography.
Saja Ismaeel, Huda Jaber Waheed, Widad Mustafa Kamel   +2 more
doaj   +1 more source

The Testicular Protection Effect of Thiamine Pyrophosphate Against Cisplatin-treated Male Rats

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022
Infertility is a worldwide problem affecting both genders, it can be defined as the inability of the adult males to make a fertile woman pregnant after one year of regular intercourse. Cisplatin considers one of the most potent antineoplastic drugs that
Maitham Abd Ali Mnati , Bahir Abdul Razzaq Mshimesh, Nadia Hamid Mohammed   +2 more
doaj   +1 more source

Effects of Saw Palmetto Therapy on some Inflammatory Biomarkers in a Sample of Iraqi Male with Symptomatic Benign Prostatic Hyperplasia

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022
Background Saw palmetto contains powerful anti-inflammatory components commonly used in Benign prostatic hyperplasia (BPH) patients with symptoms. The current study was designed to assess the effectiveness of saw palmetto alone or supplementation  
Mazin Abdulridha Ateyah, Manal Khalid Abdulridha, Munaim Jumaa Alkabee   +2 more
doaj   +1 more source