Results 21 to 30 of about 110,334 (168)

Organogel investigations as a floating oral system with depot property

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022
In this work we investigate span 40, span 60 and SA as a gelators and olive oil (OO) as apolar liquid phase to discover the ability of organogel formed to be floating in acidic media and gain a unique gastroretentive dosage form.
Zainab Saad Kaddoori, Masar Basim Mohsin Mohamed, Nawfal Am. Numan   +2 more
doaj   +1 more source

Development and validation of bioanalytical method for the determination of valsartan in human plasma

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022
A bioanalytical method which utilizes high performance liquid chromatography with mass spectrometry method has been developed and validated for the quantification of valsartan in human plasma. The samples were processed by precipitation with formic acid
Samir Hasson Aziz Ramadhan
doaj   +1 more source

Nuclear Factor Erythroid-2 Linked Factor (Nrf2) as a Potential Mediator of Hepatotoxicity

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022
Hepatotoxicity is a term used to describe serious health complications of liver disease caused by a variety of factors. Nuclear factor erythroid-2 linked factor (Nrf2) as a potential mediator of hepatotoxicity via inflammatory and induction of oxidative
Inam Sameh Arif, Israa Burhan Raoof, Hayder Hussein Luaibi   +2 more
doaj   +1 more source

Genetic Rescue of X-Linked Retinoschisis Mouse (Rs1−/y) Retina Induces Quiescence of the Retinal Microglial Inflammatory State Following AAV8-RS1 Gene Transfer and Identifies Gene Networks Underlying Retinal Recovery

Human Gene Therapy, 2020
To understand RS1 gene interaction networks in the X-linked retinoschisis (XLRS) mouse retina (Rs1 −/y), we analyzed the transcriptome by RNA sequencing before and after in vivo expression of exogenous retinoschisin (RS1) gene delivered by AAV8. RS1 is a
C. Vijayasarathy, Yong Zeng, M. Brooks, R. Fariss, P. Sieving   +4 more
semanticscholar   +1 more source

Synthesis, Antibacterial study and ADME Evaluation of Novel Isonicotinoyl Hydrazide Derivative Containing 1,3,4-Oxadiazole Moiety

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022
Novel derivative of isoniazid containing 1,3,4-oxadiazole pharmacophore has been synthesized. The chemical structure of the compound was characterized and confirmed by using FT-IR and 1H-NMR spectroscopy.
Mazen Mohammed Jwaid, Karima Fadhil Ali, Mayada Hadi Abd-alwahab   +2 more
doaj   +1 more source

TNF‐α Polymorphisms in Juvenile Idiopathic Arthritis: Which Potential Clinical Implications?

International Journal of Rheumatology, Volume 2012, Issue 1, 2012., 2012
Whether tumor necrosis factor alpha (TNF‐α) gene polymorphisms (SNPs) influence disease susceptibility and treatment of patients with juvenile idiopathic arthritis (JIA) is presently uncertain. TNF‐α is one of the most important cytokine involved in JIA pathogenesis.
A. Scardapane, L. Breda, M. Lucantoni, F. Chiarelli, Timothy Radstake   +4 more
wiley   +1 more source

Neural mechanisms of AVPR1A RS3-RS1 haplotypes that impact verbal learning and memory

NeuroImage, 2020
Converging evidence from both human and animal studies has highlighted the pervasive role of the neuropeptide arginine vasopressin (AVP), which is mediated by arginine vasopressin receptor 1A (AVPR1A), in both social and nonsocial learning and memory ...
Yan Zhang, Dan Zhu, Peng Zhang, Wei Li, W. Qin, Feng Liu, Jiayuan Xu, Qiang Xu, Junping Wang, Z. Ye, Chunshui Yu   +10 more
semanticscholar   +1 more source

Effects of Recombinant Spidroin rS1/9 on Brain Neural Progenitors After Photothrombosis-Induced Ischemia

Frontiers in Cell and Developmental Biology, 2020
The existence of niches of stem cells residence in the ventricular–subventricular zone and the subgranular zone in the adult brain is well-known. These zones are the sites of restoration of brain function after injury.
M. Moisenovich, D. Silachev, A. Moysenovich, A. Arkhipova, K. Shaitan, V. Bogush, V. G. Debabov, A. Latanov, I. Pevzner, L. Zorova, V. Babenko, E. Plotnikov, D. Zorov   +12 more
semanticscholar   +1 more source

Retinal AAV8-RS1 Gene Therapy for X-Linked Retinoschisis: Initial Findings from a Phase I/IIa Trial by Intravitreal Delivery.

Molecular Therapy, 2018
This study evaluated the safety and tolerability of ocular RS1 adeno-associated virus (AAV8-RS1) gene augmentation therapy to the retina of participants with X-linked retinoschisis (XLRS).
C. Cukras, H. Wiley, B. Jeffrey, H. Sen, Amy E Turriff, Yong Zeng, C. Vijayasarathy, D. Marangoni, L. Ziccardi, S. Kjellstrom, T. K. Park, S. Hiriyanna, J. F. Wright, P. Colosi, Zhijian Wu, R. Bush, L. Wei, P. Sieving   +17 more
semanticscholar   +1 more source

Pharmacovigilance study of tyrosine kinase inhibitors: Analysis of adverse reactions [PDF]

Pharmacia
The aim of the study is to analyze reports of adverse drug reactions published in the scientific literature occurring during and after the use of kinase inhibitors for the treatment of rheumatologic diseases to determine their type, frequency, and ...
Antoan Rangelov, Georgi Momekov, Iva Parvova, Emil Hristov, Boris Kadinov, Lyubomir Marinov   +5 more
doaj   +3 more sources