Results 1 to 10 of about 767 (112)

Spatial Reorganization of Chromatin Architecture Shapes the Expression Phenotype of Therapy-Induced Senescent Cells. [PDF]

Aging Cell
In the course of TIS, cells undergo a profound epigenomic reorganization that underlies the development of a senescence‐associated phenotype and formation of an inflammatory microenvironment. ABSTRACT Cellular senescence is a fundamental biological process contributing to aging, often accompanied by extensive chromatin remodeling.
Zhang G, Zhang W, Wang C, Jiang Z, Xu Q, Li H, Kirkland JL, Wei G, Sun Y.   +8 more
europepmc   +2 more sources

Multimodal AI-Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1. [PDF]

Adv Sci (Weinh)
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Lin W, Xu W, Liu K, Wang P, Zhu Z, Lu W, Zheng Z, Peng X, Yin X, Mei S, Pan A, Liu J, Hu L.   +12 more
europepmc   +2 more sources

Multifaceted Antipathogenic Activity of Two Novel Natural Products, Chermesiterpenoid B and Chermesiterpenoid B Seco Acid Methyl Ester, Against Pseudomonas aeruginosa. [PDF]

Microb Biotechnol
PPAR‐γ agonist Che B ester against Pseudomonas aeruginosa by inhibiting QS. ABSTRACT Pseudomonas aeruginosa is an opportunistic human pathogen that causes both acute and chronic infections due to its virulence factors, biofilm formation and the ability to suppress the host immune system.
Li DD, Wang Y, Li H, Niu WX, Hong J, Jung JH, Lee JH.   +6 more
europepmc   +2 more sources

N‐Doping Activated Presodiation Enhances Sodium‐Ion Provision in Hard Carbon Anodes

Advanced Science, Volume 13, Issue 47, 24 August 2026.
Introducing pyrrolic‐N sites enables efficient presodiation and stronger PF6− capture, thus pre ‐ forming a robust inorganic‐rich SEI layer in hard carbon anodes. ABSTRACT Hard carbon (HC) is considered the most promising anode material for commercial sodium‐ion batteries (SIBs), yet it still faces critical challenges such as low initial Coulombic ...
Hua Lin, Wenxing Miao, Yanrong Shi, Guangyi Mao, Ding Ding, Jian Weng, Zhongxiong Fan, Qingchi Xu, Jun Xu   +8 more
wiley   +1 more source

Probing 3‐Amino‐2H‐Azaindazoles as Allosteric Inhibitors of the Protein Tyrosine Phosphatase SHP2

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
A palladium‐catalyzed domino reaction facilitated the discovery and rapid synthesis of selective, potent 3‐amino‐2H‐azaindazole derivatives serving as allosteric inhibitors of SHP2. Structural analysis via co‐crystallography confirmed binding at the allosteric site, thereby stabilizing the autoinhibited SHP2 conformation, qualifying this scaffold as a ...
Machoud Amoussa, Nina‐Louisa Efrém, Feng Li, Ziqiong Guo, Yvette Roske, Katrin Jana Frank, Szymon Pach, Clemens Alexander Wolf, Feng Bo, Marina Lesina, Mika Kintzel, Rana Alsalim, Victoria Zeitz, Noémi Csorba, Silke Radetzki, György M. Keserű, Oliver Daumke, Hana Algül, Gerhard Wolber, Jia Li, Marc Nazaré   +20 more
wiley   +1 more source

Mycochemical Diversity and Therapeutic Potential of Hymenochaetoid Fungi from Central Asia: Regional and Global Perspectives

New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.
Central Asia harbors a rich yet understudied assemblage of wood‐inhabiting Hymenochaetoid fungi. This review delivers the first comprehensive synthesis of 43 poroid species representing 18 genera documented across montane forests, steppes, and xeric habitats.
Yusufjon Gafforov, Milena Rašeta, Sylvie Rapior, Manzura Yarasheva, Oksana Mykchaylova, Rustamjon Allaberdiev, Şule İnci, Dilfuza Berdieva, Arshad Mehmood Abbasi, Shikhnazar Khodjaev, Dian‐Ming Hu, Weijun Yang, Abudujilili Abuduaini, Maria Letizia Taddei, Mengcen Wang, Islomjon Urinboev, Jiajia Chen   +16 more
wiley   +1 more source

Tailoring Advanced Metal‐Based Nanomedicines for Adaptable Nanodynamic Disease Therapies and Theranostics

Advanced Materials, Volume 38, Issue 1, 2 January 2026.
This review summarizes recent advances in metal‐based nanomaterials (MBNs) as multifunctional platforms for next‐generation diagnostics and nanodynamic therapies (NDTs), highlighting their structural tunability, diverse therapeutic modalities, and broad biomedical applications in oncology and infectious disease control.
Qihang Ding, Wenhao Li, Ling Mei, Suling Luo, Jing Tao, Chongxiu Shi, Hongping Yang, Wei Feng, Yungchang Chen, Yu Chen, Jong Seung Kim, Xue Shen   +11 more
wiley   +1 more source

Exogenous Melatonin Delays the Aging of Gastrodia After Harvest and Maintains Its Quality

Journal of Food Processing and Preservation, Volume 2025, Issue 1, 2025.
Gastrodia elata is not only a traditional Chinese medicine but also a food raw material. Gastrodia is very perishable, and its effective constituents decrease significantly. N‐Acetyl‐5‐methoxytryptamine (melatonin) is widely used in the preservation of various fruits and vegetables after harvest.
Yue Chen, Ying Liu, Jialing Wang, Zhaoxing Geng, Lijun Cheng, Jingcheng Jiang, Yumei Liu, Shuyuan Zhang, Ying Yu, Zhu Li, Essam Hebishy   +10 more
wiley   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +2 more sources

Dezocine Exerts Analgesic Effects in Chronic Pain by Activation of κ‐ and μ‐Opioid Receptors and Inhibition of Norepinephrine and Serotonin Reuptake

Pain Research and Management, Volume 2025, Issue 1, 2025.
Background: Dezocine is a leading analgesic in China used for relieving moderate to severe pain. Previous studies have characterized its pharmacological properties, demonstrating its role as a partial agonist at both the κ‐opioid receptor (KOR) and the μ‐opioid receptor (MOR), thereby producing potent antinociceptive effects in acute pain models ...
Zihan Liu, Anan Liu, Jing Chen, Jing-Rui Chai, Panwen Liu, Ru-Feng Ye, Jing-Gen Liu, Yu-Jun Wang, Massimiliano Valeriani   +8 more
wiley   +1 more source