Results 1 to 10 of about 39 (19)
Probing 3‐Amino‐2H‐Azaindazoles as Allosteric Inhibitors of the Protein Tyrosine Phosphatase SHP2
ChemMedChem, Volume 21, Issue 11, 15 June 2026.A palladium‐catalyzed domino reaction facilitated the discovery and rapid synthesis of selective, potent 3‐amino‐2H‐azaindazole derivatives serving as allosteric inhibitors of SHP2. Structural analysis via co‐crystallography confirmed binding at the allosteric site, thereby stabilizing the autoinhibited SHP2 conformation, qualifying this scaffold as a ...
Machoud Amoussa +20 more
wiley +1 more source
Advanced Science, Volume 13, Issue 20, 9 April 2026.Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin +12 more
wiley +1 more source
New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.Central Asia harbors a rich yet understudied assemblage of wood‐inhabiting Hymenochaetoid fungi. This review delivers the first comprehensive synthesis of 43 poroid species representing 18 genera documented across montane forests, steppes, and xeric habitats.
Yusufjon Gafforov +16 more
wiley +1 more source
Advanced Materials, Volume 38, Issue 1, 2 January 2026.This review summarizes recent advances in metal‐based nanomaterials (MBNs) as multifunctional platforms for next‐generation diagnostics and nanodynamic therapies (NDTs), highlighting their structural tunability, diverse therapeutic modalities, and broad biomedical applications in oncology and infectious disease control.
Qihang Ding +11 more
wiley +1 more source
Aging Cell, Volume 25, Issue 1, January 2026.In the course of TIS, cells undergo a profound epigenomic reorganization that underlies the development of a senescence‐associated phenotype and formation of an inflammatory microenvironment. ABSTRACT Cellular senescence is a fundamental biological process contributing to aging, often accompanied by extensive chromatin remodeling.
Ge Zhang +8 more
wiley +1 more source
Microbial Biotechnology, Volume 18, Issue 2, February 2025.PPAR‐γ agonist Che B ester against Pseudomonas aeruginosa by inhibiting QS. ABSTRACT Pseudomonas aeruginosa is an opportunistic human pathogen that causes both acute and chronic infections due to its virulence factors, biofilm formation and the ability to suppress the host immune system.
Dan‐Dan Li +6 more
wiley +1 more source
Exogenous Melatonin Delays the Aging of Gastrodia After Harvest and Maintains Its Quality
Journal of Food Processing and Preservation, Volume 2025, Issue 1, 2025.Gastrodia elata is not only a traditional Chinese medicine but also a food raw material. Gastrodia is very perishable, and its effective constituents decrease significantly. N‐Acetyl‐5‐methoxytryptamine (melatonin) is widely used in the preservation of various fruits and vegetables after harvest.
Yue Chen +10 more
wiley +1 more source
Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +2 more sources
Pain Research and Management, Volume 2025, Issue 1, 2025.Background: Dezocine is a leading analgesic in China used for relieving moderate to severe pain. Previous studies have characterized its pharmacological properties, demonstrating its role as a partial agonist at both the κ‐opioid receptor (KOR) and the μ‐opioid receptor (MOR), thereby producing potent antinociceptive effects in acute pain models ...
Zihan Liu +8 more
wiley +1 more source