Multimodal AI-Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1. [PDF]
Adv Sci (Weinh)Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Lin W +12 more
europepmc +2 more sources
Spatial Reorganization of Chromatin Architecture Shapes the Expression Phenotype of Therapy-Induced Senescent Cells. [PDF]
Aging CellIn the course of TIS, cells undergo a profound epigenomic reorganization that underlies the development of a senescence‐associated phenotype and formation of an inflammatory microenvironment. ABSTRACT Cellular senescence is a fundamental biological process contributing to aging, often accompanied by extensive chromatin remodeling.
Zhang G +8 more
europepmc +2 more sources
Multifaceted Antipathogenic Activity of Two Novel Natural Products, Chermesiterpenoid B and Chermesiterpenoid B Seco Acid Methyl Ester, Against Pseudomonas aeruginosa. [PDF]
Microb BiotechnolPPAR‐γ agonist Che B ester against Pseudomonas aeruginosa by inhibiting QS. ABSTRACT Pseudomonas aeruginosa is an opportunistic human pathogen that causes both acute and chronic infections due to its virulence factors, biofilm formation and the ability to suppress the host immune system.
Li DD +6 more
europepmc +2 more sources
A clinical pharmacists role in primary general practice [PDF]
, 2022 Clinical pharmacist leaders are valued by the NHS because they are well educated, demonstrating excellent analytical and evidence-based thinking skills and professional competency.
core +1 more source
Factors influencing the commissioning and provision of community pharmacy Emergency Hormonal Contraception services in England [PDF]
, 2022 In England, community pharmacies provide services commissioned either nationally or locally. Local commissioning exhibits variation in specification and implementation, exemplified by Emergency Hormonal Contraception (EHC) services.
Thayer, Nicholas Mark
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Functional Recellularization of Acellular Rat Liver Scaffold by Induced Pluripotent Stem Cells: Molecular Evidence for Wnt/B-Catenin Upregulation. [PDF]
, 2021 BACKGROUND: Liver transplantation remains the only viable therapy for liver failure but has a severely restricted utility. Here, we aimed to decellularize rat livers to form acellular 3D bio-scaffolds suitable for seeding with induced pluripotent cells ...
core +1 more source
Healthcare professionals' perceptions and perspectives on biosimilar medicines and the barriers and facilitators to their prescribing in UK: a qualitative study. [PDF]
, 2018 OBJECTIVE: To investigate UK healthcare professionals' perceptions and perspectives towards biosimilar infliximab, etanercept and insulin glargine and the potential barriers and facilitators to their prescribing.
core +1 more source
Pharmacological or non-pharmacological interventions for treatment of common mental disorders associated with Tuberculosis: A systematic review. [PDF]
, 2021 We aimed to review the literature on interventions for treating Common Mental Disorders (CMD) in people with Tuberculosis (TB). We followed PRISMA guidelines and the protocol was registered at PROSPERO. The electronic databases (PsycInfo, CINAHL, Medline,
Farooq, Saeed
core +1 more source
Effectiveness of medicines authentication technology to detect counterfeit, recalled and expired medicines: a two-stage quantitative secondary care study. [PDF]
, 2016 OBJECTIVES: To identify the authentication and detection rate of serialised medicines using medicines authentication technology. DESIGN AND INTERVENTION: 4192 serialised medicines were entered into a hospital dispensary over two separate 8-week stages in
core +1 more source
Natural products: chemistry, bioactivity and application [PDF]
, 2023 The focus of research group from Department of Pharmacognosy at the Faculty of Pharmacy in Belgrade is on natural products, their chemistry and application.
Kukić-Marković, Jelena
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