Results 101 to 110 of about 164,355 (372)
Advanced Science, EarlyView.It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li +9 more
wiley +1 more source
Measurement of Common Risk Factors: A Panel Quantile Regression Model for Returns
, 2017 This paper investigates how to measure common market risk factors using newly proposed Panel Quantile Regression Model for Returns. By exploring the fact that volatility crosses all quantiles of the return distribution and using penalized fixed effects ...
Barunik, Jozef, Cech, Frantisek
core +1 more source
Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases [PDF]
, 2014 Physical inactivity is a predisposing factor for various disease states including obesity, cardiovascular disease, as well as for certain types of cancer. Regular endurance exercise mediates several beneficial effects such as increased energy expenditure
Handschin, Christoph +1 more
core +1 more source
Advanced Science, EarlyView.This study describes derivation of two distinct mechanosensory subpopulations from human pluripotent stem cells using a transcription factor mediated approach. Of significance, functional interrogation of induced mechanosensory subtypes reveal their unique responses to mechanical stimulation in the absence of end‐organs.
Amy J. Hulme +12 more
wiley +1 more source
Viral etiological causes of febrile seizures for respiratory pathogens (EFES Study)
Human Vaccines & Immunotherapeutics, 2019 Background: Febrile seizure is the most common childhood neurological disorder, is an important health problem with potential short- and long-term complications, also leading to economic burden and increased parental anxiety about fevers and seizures ...
Kursat Bora Carman +19 more
doaj +1 more source
Colouring inside what lines?: interference of the urban growth boundary and the political-administrative border of Brussels [PDF]
, 2013 This paper discusses the relationship between the political-administrative border and the urban growth boundary around Brussels, the Belgian capital. Our hypothesis is that the interests of the various regions and language groups in Belgium interfere ...
Allaert, Georges +2 more
core +1 more source
Toward unified molecular surveillance of RSV: A proposal for genotype definition
Influenza and Other Respiratory Viruses, 2020 Human respiratory syncytial virus (RSV) is classified into antigenic subgroups A and B. Thirteen genotypes have been defined for RSV‐A and 20 for RSV‐B, without any consensus on genotype definition.
S. Goya +7 more
semanticscholar +1 more source
Advanced Science, EarlyView.An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz +10 more
wiley +1 more source
Advanced Science, EarlyView.Virucidal polymers serve as effective antivirals by not only inhibiting viruses but also destroying them. Inspired by the chemical properties of mucin‐mimetics, dendronized polyglycerol‐sulfated, mucin‐inspired amphiphilic copolymers (MIACPs) have been developed.
Raju Bej +10 more
wiley +1 more source
Human Vaccines & Immunotherapeutics, 2018 Peptide antigens are combined with an adjuvant in order to increase immunogenicity in vivo. The immunogenicity and safety of a RSV vaccine formulated in a novel oil-based platform, DepoVax™ (DPX), was compared to an alum formulation.
Lisa D. MacDonald +9 more
doaj +1 more source