Results 111 to 120 of about 152,172 (364)

Single‐Cell Transcriptomic Analysis of the Immune Response to COVID‐19 and Tuberculosis Coinfection

Exploration, EarlyView.
Understanding the immunological basis for severe outcomes in COVID‐19/Tuberculosis coinfection is critical. Our single‐cell analysis identifies key drivers: profound lymphocyte loss through combined apoptosis and altered trafficking, excessive S100 protein‐mediated inflammation contributing to cytokine storms, and systemic immune dysfunction ...
Yi Wang, Maike Zheng, Yun Zhang, Yu Xue, Sibo Long, Chaohong Wang, Qing Sun, Jun Yan, Yiheng Shi, Bin Yang, Shang Ma, Tiantian Zhang, Lei Cao, Yan Chen, Wenfu Ju, Jing Zhang, Yan Zhao, Mengqiu Gao, Laurence Don Wai Luu, Xinting Yang, Guirong Wang   +20 more
wiley   +1 more source

Bronchiolitis. Analysis of 10 consecutive epidemic seasons [PDF]

, 2016
Bronchiolitis is the leading cause of hospitalization in infants under 12 months. Our aims were to analyze epidemiological characteristics of infants with bronchiolitis over 10 consecutive seasons and to evaluate whether there are any clinical ...
Antonelli, Guido, Cangiano, Giulia, Capocaccia, Paolo, Evangelisti, Melania, Frassanito, Antonella, Midulla, Fabio, Moretti, Corrado, Nenna, Raffaella, Nicolai, Ambra, Papoff, Paola, Petrarca, Laura, Pierangeli, Alessandra, Scagnolari, Carolina   +12 more
core   +1 more source

Respiratory Syncytial Virus (RSV) Neutralizing Antibodies at Birth Predict Protection from RSV Illness in Infants in the First 3 Months of Life

Clinical Infectious Diseases, 2020
Background Respiratory syncytial virus (RSV) is a leading cause of viral pneumonia and bronchiolitis during the first 6 months of life. Placentally transferred antibodies can prevent severe RSV illness, and maternal immunization may reduce illness in ...
A. Buchwald, B. Graham, A. Traoré, F. Haidara, Man Chen, Kaitlyn M. Morabito, Bob C. Lin, S. Sow, M. Levine, M. Pasetti, Milagritos D. Tapia   +10 more
semanticscholar   +1 more source

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, EarlyView.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

Respiratory syncytial virus outbreak in a long-term care facility detected using reverse transcriptase polymerase chain reaction: an argument for real-time detection methods. [PDF]

, 2009
ObjectivesTo report an outbreak of respiratory synctyial virus (RSV) in a long-term care facility (LTCF) during ongoing routine respiratory illness surveillance.DesignRapid antigen testing, viral culture, direct fluorescent antibody (DFA) testing, and ...
Caram, L Brett, Chen, Jodi, Hillyard, David R, Petti, Cathy A, Polage, Christopher R, Schmader, Kenneth, She, Rosemary, Taggart, E William, Twersky, Jack, Woods, Christopher W   +9 more
core  

Update on current views and advances on RSV infection (Review)

International Journal of Molecular Medicine, 2020
Respiratory syncytial virus (RSV) infection represents an excellent paradigm of precision medicine in modern paediatrics and several clinical trials are currently performed in the prevention and management of RSV infection.
I. Mammas, S. Drysdale, B. Rath, M. Theodoridou, G. Papaioannou, Alexia Papatheodoropoulou, E. Koutsounaki, C. Koutsaftiki, Eleftheria Kozanidou, Vassilis Achtsidis, Paraskevi Korovessi, G. Chrousos, D. Spandidos   +12 more
semanticscholar   +1 more source

Bactericidal, Virucidal, and Biocompatible Properties of 3D Printed Materials Enhanced with Copper and Zinc Nanoparticles

Global Challenges, EarlyView.
As population growth, urbanization, and climate change increase the spread of pathogens, hospital infections now affect 1 in 31 patients, costing billions annually. This study presents a new approach by integrating copper and zinc oxide nanoparticles into 3D‐printed materials.
Andrei‐Florin Sandu, Lauren Acton, Phillip Gould   +2 more
wiley   +1 more source

Preparing for AI in Resident Selection: A Scoping Review of Current Applications and Limitations

The Laryngoscope, EarlyView.
In examining the literature for articles on the use of artificial intelligence in the residency applicant selection process, we have identified several studies that highlight the potential of these tools for reducing biases and identifying strong candidates. There remains substantial room for additional research exploring this topic.
Gillian Michaelson, Daniel Karasik, Eleanor Polen, Sanjeet V. Rangarajan, Nina W. Zhao   +4 more
wiley   +1 more source

Decrease in formalin-inactivated respiratory syncytial virus (FI-RSV) enhanced disease with RSV G glycoprotein peptide immunization in BALB/c mice. [PDF]

PLoS ONE, 2013
Respiratory syncytial virus (RSV) is a high priority target for vaccine development. One concern in RSV vaccine development is that a non-live virus vaccine would predispose for enhanced disease similar to that seen with the formalin inactivated RSV (FI ...
Gertrud U Rey, Congrong Miao, Hayat Caidi, Suvang U Trivedi, Jennifer L Harcourt, Ralph A Tripp, Larry J Anderson, Lia M Haynes   +7 more
doaj   +1 more source

Protein Post‐Translational Modification‐Mediated Control of Type I Interferon Cascade Signaling

Medicine Bulletin, EarlyView.
ABSTRACT Type I interferons (IFN‐Is) constitute the primary defense mechanism against pathogenic infections in the human body. The antiviral signaling mediated by IFN‐I is integral to the host immune response. Nevertheless, an imbalance in IFN‐I function can perturb the organism’s homeostasis. Consequently, it is imperative for the body to meticulously
Xiangjie Chen, Qiao Cheng, Fang Gong, Hui Zheng   +3 more
wiley   +1 more source