Results 51 to 60 of about 77,778 (298)

RSV-specific IgG against individual RSV glycoproteins do not correlate with disease severity.

, 2017
RSV glycoprotein-specific antibody levels were determined by ELISA against recombinant, soluble ectodomains. Median IgG levels (± IQR) were compared between healthy and RSV-infected infants as well as between RSV patients with and without oxygen therapy.
Ivy Widjaja (128545), Ronald de Groot (54924), Oliver Wicht (440906), Willem Luytjes (349214), Teun Guichelaar (3704830), Jop Jans (3704833), Gerben Ferwerda (60600), Marien I. de Jonge (527369), Inge M. L. Ahout (3704827), Cornelis A. M. de Haan (90844)   +9 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

RSV specific IgG and isotype IgG antibody responses after prime immunization with FI-RSV-via IM or MN patch.

, 2018
RSV specific IgG, isotype IgG1 and Ig2a serum antibodies were determined at 2 weeks after prime immunization (n = 5) by ELISA using FI-RSV as a coating antigen. (A) IgG, (B) IgG1 and (C) IgG2a levels.
Barney Graham (5900309), Young-Tae Lee (467116), Young-Man Kwon (467115), Soojin Park (516759), Sang-Moo Kang (329015), Mark R. Prausnitz (314166), Manki Song (317984), Jae Hwan Jung (1450003), Youri Lee (813830), Eun-Ju Ko (467120), Ki-Hye Kim (813829)   +10 more
core   +1 more source

Genome structures of the rHPIV3-RSV-F vectors.

, 2020
The codon-optimized RSV F ORF containing the HEK and DS-Cav1 mutations (see Results) was engineered to contain an optimal translational start site (underlined and labeled “Kozak” [36]) and was flanked by HPIV3 gene-end (GE) and gene-start (GS ...
Sonja Surman (185609), Barney S. Graham (7400855), Xiang Liu (119470), Emerito Amaro-Carambot (185611), Xueqiao Liu (765408), Peter L. Collins (7252565), Peter D. Kwong (161423), Shirin Munir (223824), Bo Liang (450389)   +8 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Respiratory Syncytial Virus Infection Induces Expression of Inducible Nitric Oxide Synthase, CD3, and CD8 in Naturally Occurring Pneumonia in Lambs

Acta Veterinaria, 2021
Respiratory syncytial virus (RSV) is an RNA virus that belongs to the Pneumovirus genus of the Paramyxoviridae family. The aim of this study was to evaluate the expressions of inducible nitric oxide synthetase (iNOS), CD3 (pan T cells), and CD8 ...
Yaman Turan, Aydemir Ceyhun
doaj   +1 more source

Viral Infection‐Inspired Autonomous Detection of Fusion‐Competent Viruses for Screening and Environmental Surveillance

Advanced Materials, EarlyView.
Inspired by viral entry mechanisms, the FUSION assay enables autonomous detection of respiratory viruses via membrane fusion–triggered CRISPR‐Cas13a activation. VEACON selectively fuses with fusion‐competent viruses, triggering fluorescence within confined vesicles.
Jae Chul Park, Yidam Song, Hyun‐Woo Choi, Jaeuk Sung, Harin Jin, WonSeok Gwak, Kirim Yoo, Soohwang Lee, Jongeon Park, Jeongmin Kim, Hye‐Jun Jo, Jahyun Koo, Youngdo Jeong, Kwan Hyi Lee, Seung‐Jung Kee, Hojun Kim   +15 more
wiley   +1 more source

Stability of expression of RSV F protein by rHPIV3-RSV-F vectors evaluated by a double-staining immunofluorescence plaque assay.

, 2020
Vero cells were inoculated with 10-fold serial dilutions of the P4 stock of F-H3TMCT/N-P obtained from terminal dilution from transfection #1 and P2 stocks of F/preN, F-H3TMCT/preN, and F/N-P from transfection #2 (see Results).
Sonja Surman (185609), Barney S. Graham (7400855), Xiang Liu (119470), Emerito Amaro-Carambot (185611), Xueqiao Liu (765408), Peter L. Collins (7252565), Peter D. Kwong (161423), Shirin Munir (223824), Bo Liang (450389)   +8 more
core   +1 more source

Time‐Multiplexed Organic Electrochemical Transistor for Saliva‐Based Rapid Detection of Viral Proteins

Advanced Science, EarlyView.
A time‐multiplexed nanobody‐functionalized organic electrochemical transistor enables rapid and sensitive detection of three respiratory viral proteins from saliva. Sequentially addressed multi‐gate electrodes on a shared channel achieve around 1 fm detection within 15 min without sample preprocessing. Clinical validation demonstrates high specificity,
Tianrui Chang, Yuxiang Ren, Shofarul Wustoni, Atheer Alqatari, Adel Hama, Yazhou Wang, Long Chen, Jessica Parrado Agudelo, Luca Salvigni, Keying Guo, Ashraf Dada, Stefan T. Arold, Raik Grünberg, Sahika Inal   +13 more
wiley   +1 more source

Immunity to RSV in Early-Life [PDF]

Frontiers in Immunology, 2014
Respiratory Syncytial Virus (RSV) is the commonest cause of severe respiratory infection in infants, leading to over 3 million hospitalizations and around 66,000 deaths worldwide each year. RSV bronchiolitis predominantly strikes apparently healthy infants, with age as the principal risk factor for severe disease. The differences in the immune response
Lambert, L, Sagfors, AM, Openshaw, PJ, Culley, FJ   +3 more
openaire   +4 more sources