Results 81 to 90 of about 164,355 (372)

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Cochlear implant

JKS (Jurnal Kedokteran Syiah Kuala), 2008
Abstrak.   Cochlear implant (Cl)  merupakan   alat  elektronik    yang  sebagiannya   ditanam    melalui    prosedur pembedahan    dan   sebagian  lagi  berada  di   luar tubuh,     memiliki    fungsi  memperbaiki   proses  rnendengar dan komunikasi ...
Teuku Husni T.R
doaj  

RSV A2-Based Prefusion F Vaccine Candidates Induce RSV A and RSV B Cross Binding and Neutralizing Antibodies and Provide Protection against RSV A and RSV B Challenge in Preclinical Models

Vaccines, 2023
RSV is divided into two antigenic subtypes, RSV A and RSV B, which is largely based on the variation in the G protein, while the fusion protein F is more conserved and a target for antibody-mediated neutralization. Here we evaluate the breadth of the protective immune responses across RSV A and RSV B subtypes, induced by vaccines based on the RSV A ...
Freek Cox, Eirikur Saeland, Anne Thoma, Ward van den Hoogen, Lisanne Tettero, Joke Drijver, Cornelis Vaneman, Yolinda van Polanen, Tina Ritschel, Arangassery Rosemary Bastian, Benoit Callendret, Roland Zahn, Leslie van der Fits   +12 more
openaire   +3 more sources

De novo protein design enables the precise induction of RSV-neutralizing antibodies

Science, 2020
TopoBuilding precision vaccines To induce strong and targeted neutralizing antibody (nAb) responses against vaccine targets, one strategy has been to use computationally designed immunogens. However, the structural complexity of many known neutralization
F. Sesterhenn, Che Yang, J. Bonet, J. T. Cramer, X. Wen, Yimeng Wang, Chi-I Chiang, L. Abriata, I. Kucharska, G. Castoro, Sabrina S. Vollers, M. Galloux, E. Dheilly, S. Rosset, P. Corthésy, S. Georgeon, M. Villard, Charles-Adrien Richard, D. Descamps, T. Delgado, E. Oricchio, M. Rameix-Welti, V. Mas, S. Ervin, J. Éléouët, S. Riffault, J. Bates, J. Julien, Yuxing Li, T. Jardetzky, T. Krey, B. Correia   +31 more
semanticscholar   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

A new subunit vaccine based on nucleoprotein nanoparticles confers partial clinical and virological protection in calves against bovine respiratory syncytial virus [PDF]

, 2010
Human and bovine respiratory syncytial viruses (HRSV and BRSV) are two closely related, worldwide prevalent viruses that are the leading cause of severe airway disease in children and calves, respectively.
Bernadet, Philippe, Bernard, Julie, Bernex, Florence, Castagné, Nathalie, Deplanche, Martine, Deville, Sébastien, Dubosclard, Virginie, Dubuquoy, Catherine, Durand, Guillaume, Eléouët, Jean-François, Meyer, Gilles, Petit-Camurdan, Agnès, Riffault, Sabine, Schwartz-Cornil, Isabelle, Soulestin, Marion   +14 more
core   +2 more sources

Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection

Science, 2020
ACHOO!-trophils? Why some individuals come down with a cold in any given year, whereas others are spared, is poorly understood. Habibi et al. exposed volunteers to respiratory syncytial virus (RSV), one of the pathogens responsible for the common cold ...
M. Habibi, R. Thwaites, Meiping Chang, A. Jóźwik, A. Paras, F. Kirsebom, A. Varese, Amber Owen, L. Cuthbertson, P. James, T. Tunstall, D. Nickle, T. Hansel, M. Moffatt, C. Johansson, C. Chiu, P. Openshaw   +16 more
semanticscholar   +1 more source

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

Advanced Healthcare Materials, EarlyView.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H. Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez‐Paggi, Salvador Ventura   +11 more
wiley   +1 more source

RSV-Prophylaxe

Pädiatrie & Pädologie
ZusammenfassungHändedesinfektion und Mund-Nasen-Schutz sind hocheffektive Prophylaxemaßnahmen, wie die COVID-19-Pandemie gezeigt hat. Nach 25 Jahren medikamentöser Prophylaxe mit dem monoklonalen Antikörper Palivizumab und zahlreichen Schwierigkeiten in der Umsetzung bei Risikokindern (Compliance, saisonale Problematik, monatliche i.m.-Gaben, hohe ...
Bernhard Resch, Gülsen Sever-Yildiz
openaire   +2 more sources

Respiratory syncytial virus outbreak in a long-term care facility detected using reverse transcriptase polymerase chain reaction: an argument for real-time detection methods. [PDF]

, 2009
ObjectivesTo report an outbreak of respiratory synctyial virus (RSV) in a long-term care facility (LTCF) during ongoing routine respiratory illness surveillance.DesignRapid antigen testing, viral culture, direct fluorescent antibody (DFA) testing, and ...
Caram, L Brett, Chen, Jodi, Hillyard, David R, Petti, Cathy A, Polage, Christopher R, Schmader, Kenneth, She, Rosemary, Taggart, E William, Twersky, Jack, Woods, Christopher W   +9 more
core