Results 1 to 10 of about 8,311 (171)

Decreased Expression by a Chemically Modified siRNA to PTBP1 Seriously Affects Warburg Effect in Colorectal Cancer Cells. [PDF]

Cancer Sci
Chemically modified siR‐PTBP1 disrupts the Warburg effect by reprogramming pyruvate kinase splicing from PKM2 to PKM1. This metabolic shift activates the TCA cycle, increases ATP production, and excessive ROS generation, and ultimately induces apoptotic cell death in colorectal cancer cells.
Matsumoto K, Hayashi H, Tokumaru Y, Fujibayashi S, Mitsui N, Endo M, Horaguchi T, Hatanaka Y, Yokoi R, Mizutani C, Kuno M, Fukada M, Asai R, Yasufuku I, Sato Y, Tajima JY, Tanaka Y, Nakashima R, Akao Y, Matsuhashi N.   +19 more
europepmc   +2 more sources

Sorafenib Restores Pentose Phosphate Pathway-Related Redox Homeostasis via the c-Raf/HSP90/G6PD Axis in Hepatic Ischemia-Reperfusion Injury. [PDF]

MedComm (2020)
Gao F, Dong L, Tan Y, Zhang Z, Xu S, Lou Z, Wu Y, Chen S, Zhuang L, Lian Z, Zheng S, Qiu N, Wang K, Xu X.   +13 more
europepmc   +1 more source

Insulin and Insulin-like Growth Factor 1 Signaling as a Modulator of MYC Expression in the Meibomian Gland. [PDF]

Biomedicines
Verling C, Berlied A, Peterson C.
europepmc   +1 more source

Establishing the clinical utility of integrated quasistatic acoustic tweezing thromboelastometry for blood coagulation analysis. [PDF]

J Thromb Haemost
Pham HQ, Barnor C, Paul T, Cummins EM, Arango D, Yockelson S, Khismatullin DB.   +6 more
europepmc   +1 more source

NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates. [PDF]

Nat Commun
Glon D, Riller Q, Álvarez L, Gioja L, Rivière F, Léonardon B, Aktary Z, Guillemot A, Sago L, Pellé O, Ho ND, Brochard K, Brunaud C, Seabra L, Rice GI, Bondet V, Duffy D, Bader-Meunier B, Frémond ML, Lepelley A, Crow YJ, Tusseau M, Belot A, Lagaudrière-Gesbert C, Rieux-Laucat F, Gaudin Y.   +25 more
europepmc   +1 more source

Japanese encephalitis virus hijacks the host purine biosynthetic network to promote viral replication in neurons. [PDF]

PLoS Pathog
Gu J, Fan C, Xiang S, Yang L, Liu J, Si Y, Zhu B, Sun Y, Ding C, Cao S, Ye J.   +10 more
europepmc   +1 more source

Mitochondria-targeted nanozyme hydrogel remodels the microenvironment to enhance bone regeneration in diabetes-associated periodontitis. [PDF]

J Nanobiotechnology
Yan J, Cui C, Zhou L, Xu Y, Zhang K, Liu K, Gong Y, Zhou J, Wu X, Li B.   +9 more
europepmc   +1 more source

Metabolic atlas of early human cortex reveals glycolytic remodeling and pentose phosphate pathway control of cell fate transitions. [PDF]

Cell
Mil J, Soto JA, Krall AS, Peloggia J, Frigui S, Fong OS, Sathe L, Matulionis N, Day F, Stiles L, Montales KP, Azizad DJ, Gonzalez CE, Fazzari E, Li MX, Nano PR, Martija AA, Perez-Ramirez CA, Nguyen CV, Wick B, Ge W, Kan RL, Andrews MG, Haeussler M, Wells MF, Christofk HR, Bhaduri A.   +26 more
europepmc   +1 more source

Boosting NADPH with GABA: Converting aged seeds to functional soybean sprouts. [PDF]

Food Chem X
Yu S, Yin J, Meng F, Hua K, Zhao K, Li F, Zhao T, Wang Y, Zhang Y, Zhang C, Yu L.   +10 more
europepmc   +1 more source

Pubertal dysfunctions in intracranial germ cell tumors. [PDF]

Front Endocrinol (Lausanne)
Partenope C, Criscuolo S, Carceller F, Albanese A.   +3 more
europepmc   +1 more source