RTK Inhibitors in Melanoma: From Bench to Bedside
Simple Summary Receptor tyrosine kinases (RTKs) have long been demonstrated to play key roles in melanoma development. RTK activation requires dimerization and intracellular tyrosine trans-phosphorylation leading to downstream signaling pathways ...
Malak Sabbah +5 more
semanticscholar +1 more source
A homogeneous multiplex immunoassay for RTK phosphorylation state that is adaptable to HTS Jane Schmidt, Ph.D., Judy Haning, Shaya Anderson, Richard Fuerstenberg. R&D Systems, Inc. Minneapolis, MN Receptor Tyrosine Kinases (RTKs) are widely expressed transmembrane protein receptors for various extracellular ...
Jane Schmidt, Jane Schmidt
openaire +1 more source
Parsimony and complexity: Cell fate assignment in the developing Drosophila eye
The specification of the R7 photoreceptor in the Drosophila eye has become a classic model for understanding how cell fates are assigned in developing systems.
Yannis Emmanuel Mavromatakis +1 more
doaj +1 more source
Kinematic analysis of the Pakuashan fault tip fold, west central Taiwan: Shortening rate and age of folding inception [PDF]
The Pakuashan anticline is an active fault tip fold that constitutes the frontal most zone of deformation along the western piedmont of the Taiwan Range.
Avouac, Jean Philippe +7 more
core +4 more sources
On the accuracy of low-cost dual-frequency GNSS network receivers and reference data
The trend in spatial data accuracy has gone from meters to decimeters and even centimeter levels in the last two decades. In large part, the centimeter(s) level spatial accuracies of geospatial products result from the use of LiDAR data and both low ...
Michael E. Hodgson
doaj +1 more source
Posicionamento GNSS em Tempo Real: Evolução, Aplicações Práticas e Perspectivas para o Futuro
O posicionamento em tempo real por meio do emprego dos sinais de satélites foi um avanço nas navegações aérea, marítima e terrestre com o surgimento do GPS (Global Positioning System).
Claudia Pereira Krueger +4 more
doaj +1 more source
Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia. [PDF]
High hyperdiploidy (HD), the most common cytogenetic subtype of B-cell acute lymphoblastic leukemia (B-ALL), is largely curable but significant treatment-related morbidity warrants investigating the biology and identifying novel drug targets.
de Smith, Adam J +10 more
core +1 more source
Current Situation of GNSS Networks in Romania
Nowadays, the need for a more precise positioning is a very high, therefore very demanding one, and this is one of the reasons why very large research funding is allocated in satellite technology, the second reason being global geopolitics situation. New
Alexandru Iulian ILIESCU +4 more
doaj +1 more source
BAC-FISH assays delineate complex chromosomal rearrangements in a case of post-Chernobyl childhood thyroid cancer [PDF]
Structural chromosome aberrations are known hallmarks of many solid tumors. In the papillary form of thyroid cancer (PTC), for example, activation of the receptor tyrosine kinase (RTK) genes, RET and neurotrophic tyrosine kinase receptor type I (NTRK1)
Baumgartner, Adolf +6 more
core +2 more sources
3D Mapping Database-Aided GNSS RTK and Its Assessments in Urban Canyons
Different revolutionary applications, like the unmanned autonomous systems, require a highly precise positioning with centimetre-level accuracies. And real-time kinematic (RTK) GNSS positioning stands a chance to these potential applications.
Hoi-Fung Ng, L. Hsu
semanticscholar +1 more source

