Results 41 to 50 of about 119,552 (307)

Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival

Disease Models & Mechanisms, 2022
Activating anaplastic lymphoma kinase (ALK) receptor tyrosine kinase (RTK) mutations occur in pediatric neuroblastoma and are associated with poor prognosis. To study ALK-activating mutations in a genetically controllable system, we employed CRIPSR/Cas9,
Kathrin Pfeifer, Georg Wolfstetter, Vimala Anthonydhason, Tafheem Masudi, Badrul Arefin, Mats Bemark, Patricia Mendoza-Garcia, Ruth H. Palmer   +7 more
doaj   +1 more source

FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells [PDF]

, 2014
Receptor Tyrosine Kinases (RTKs) and Focal Adhesion Kinase (FAK) regulate multiple signalling pathways, including mitogen-activated protein (MAP) kinase pathway. FAK interacts with several RTKs but little is known about how FAK regulates their downstream
A Bergmann, A Boulay, A Ueda, AC Dar, B Corkery, B Gabriel, BA Edgar, BA Hay, BJ Dickson, C Grabbe, CJ Marshall, D Tenenbaum, DD Schlaepfer, DJ Sieg, E Macia, E Rainero, E Rainero, E Sandilands, E Sandilands, Emma Sandilands, FD Karim, FJ Diaz-Benjumea, G Adam, GL Fox, I Bongarzone, I Plaza-Menacho, I Rebay, Iain MacPherson, IH Gelman, J Cordero, J Fujimoto, J Verdu, J Zhao, Jesica Diaz Vera, Jim C. Norman, JR Infante, JT Parsons, JT Price, Juan Pablo Macagno, K Blochlinger, K Halfar, K Mesaki, K Sawamoto, L Henriksen, L Sadowski, LV Owens, M Agochiya, M Ayaki, M Freeman, M Grieco, M Miaczynska, M Roberts, M Santoro, M Therrien, M Vidal, M Vidal, Marcos Vidal, Margaret Frame, Marshall S. Horwitz, MC Frame, ME Grether, ME Irwin, MM Bradford, P Kurada, P-I Tsai, PM Siesser, R Gleichauf, R Ohta, RD Read, RH Palmer, Ruth Palmer, S Leboulleux, S Murakami, S Rizzolio, S Sigismund, SA Speicher, SM Jhiang, SY Chen, T Das, T Matsuo, T-H Chen, W Long, WG Cance, X Zhao, Y Zheng, Yachuan Yu, Z Lu   +86 more
core   +4 more sources

Validation of the accuracy of geodetic automated measurement system based on GNSS platform for continuous monitoring of surface movements in post-mining areas

Reports on Geodesy and Geoinformatics, 2021
The problem involving the monitoring of surface ground movements in post-mining areas is particularly important during the period of mine closures. During or after flooding of a mine, mechanical properties of the rock mass may be impaired, and this may ...
Sokoła-Szewioła Violetta, Siejka Zbigniew   +1 more
doaj   +1 more source

Morphological updating on the basis of integrated DTMs: study on the Albano and Nemi craters [PDF]

, 2008
The Colli Albani Volcano has recently developed particular interest in the geophysical community for some peculiar characteristics imputable to a recent residual volcanic activity, thus evidencing that it cannot be considered extinguished yet.
Augusto Mazzoni, Federica Riguzzi, Grazia Pietrantonio, Ulisse Fabiani, Valerio Baiocchi   +4 more
core   +1 more source

Accuracy assessment of RTK/PPK UAV-photogrammetry projects using differential corrections from multiple GNSS fixed base stations

Geocarto International, 2023
Unmanned aerial vehicles (UAVs) equipped with global navigation satellite system-real-time kinematic (GNSS RTK) receivers allow direct georeferencing of the photogrammetric project without using ground control points (GCPs).
Patricio Martínez-Carricondo, Francisco Agüera-Vega, Fernando Carvajal-Ramírez   +2 more
doaj   +1 more source

Pedestrian navigation: how can inertial measurment units assist smartphones?

Российский технологический журнал, 2021
This paper is devoted to construction of reference walking trajectories for developing pedestrian navigation algorithms for smartphones. Such trajectories can be used both for verification of classical algorithms of navigation or for application of ...
I. A. Chistyakov, I. V. Grishov, A. A. Nikulin, M. V. Pikhletsky, I. B. Gartseev   +4 more
doaj   +1 more source

FLAMINGO – Fulfilling enhanced location accuracy in the mass-market through initial GalileO services [PDF]

, 2018
This paper discusses FLAMINGO, an initiative that will provide a high accuracy positioning service to be used by mass market applications. The status and future for the initiative are discussed, the required accuracies and other location parameters are ...
Arzel, Laurent, Callewaert, Karel, Critchley-Marrows, Joshua, Fortunato, Marco, Ivanovici, Maria, Pomies, Axelle, Roberts, William, Tavares, Thiago   +7 more
core   +1 more source

Below the Surface: IGF-1R Therapeutic Targeting and Its Endocytic Journey

Cells, 2019
Ligand-activated plasma membrane receptors follow pathways of endocytosis through the endosomal sorting apparatus. Receptors cluster in clathrin-coated pits that bud inwards and enter the cell as clathrin-coated vesicles.
Caitrin Crudden, Dawei Song, Sonia Cismas, Eric Trocmé, Sylvya Pasca, George A. Calin, Ada Girnita, Leonard Girnita   +7 more
doaj   +1 more source

Performance analysis of multi-GNSS static and RTK techniques in estimating height differences

International Journal of Digital Earth, 2020
Establishing reliable elevation differences is imperative for most geoscience and engineering applications. This work has traditionally been accomplished through spirit leveling techniques; however, surveyors have been utilizing satellite positioning ...
Ahmed Elaksher, Tarig Ali, Franck Kamtchang, Christian Wegmann, Adalberto Guerrero   +4 more
doaj   +1 more source

Static Positioning under Tree Canopy Using Low-Cost GNSS Receivers and Adapted RTKLIB Software

Sensors, 2023
The decrease in costs and dimensions of GNSS receivers has enabled their adoption for a very wide range of users. Formerly mediocre positioning performance is benefiting from recent technology advances, namely the adoption of multi-constellation, multi ...
Julián Tomaštík, Tim Everett
doaj   +1 more source