Results 51 to 60 of about 52,420 (290)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Fusion positioning method of “RTK+INS+Odometer” in unmanned mining trucks in open-pit mines

Meitan kexue jishu
To address the positioning inaccuracies of Real-Time Kinematic (RTK) technology caused by GPS signal attenuation, multipath, and communication interruptions in deep open-pit mines for unmanned mining trucks, as well as the errors in integrated inertial ...
Qinghua Mao, Zhuohang Ren, Song Qin, Hongwei Ma, Xusheng Xue   +4 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Current and Emerging Therapeutic Approaches for Extracranial Malignant Rhabdoid Tumors

Cancer Management and Research, 2022
Karolina Nemes,1 Pascal D Johann,1,2 Stefanie Tüchert,3 Patrick Melchior,4 Christian Vokuhl,5 Reiner Siebert,6 Rhoikos Furtwängler,7 Michael C Frühwald1 1Paediatrics and Adolescent Medicine, Swabian Children’s Cancer Center, University Medical Center ...
Nemes K, Johann PD, Tüchert S, Melchior P, Vokuhl C, Siebert R, Furtwängler R, Frühwald MC   +7 more
doaj  

Integrity monitoring scheme for undifferenced and uncombined multi-frequency multi-constellation PPP-RTK

, 2023
The precise point positioning (PPP)-based real-time-kinematic (RTK) method attracts increasing attention from both academia and industry because of its potential for high accuracy positioning with a shorter convergence time compared to the traditional ...
W. Zhang (820655), C. Rizos (23320150), J. Wang (472325), Ahmed El-Mowafy (23290597)   +3 more
core  

Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light

Advanced Science, EarlyView.
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley   +1 more source

Integration of GNSS technologies into the geodesic monitoring and mining transport management system

Технічна інженерія
The paper examines the theoretical, methodological, and practical aspects of integrating GNSS technologies into the geodetic monitoring and mining transport management system within the context of the mining industry’s digital transformation.
A.V. Panasiuk, V.O. Shlapak, D.O. Tarnavsky, Ya.R. Shapar   +3 more
doaj   +1 more source

Tissue-Specific Gain of RTK Signalling Uncovers Selective Cell Vulnerability during Embryogenesis. [PDF]

PLoS Genetics, 2015
The successive events that cells experience throughout development shape their intrinsic capacity to respond and integrate RTK inputs. Cellular responses to RTKs rely on different mechanisms of regulation that establish proper levels of RTK activation ...
Yannan Fan, Sylvie Richelme, Emilie Avazeri, Stéphane Audebert, Françoise Helmbacher, Rosanna Dono, Flavio Maina   +6 more
doaj   +1 more source

QoS-aware reference station placement for regional network RTK [PDF]

, 2009
Network RTK (Real-Time Kinematic) is a technology that is based on GPS (Global Positioning System) or more gener-ally on GNSS (Global Navigation Satellite System) measurements to achieve centimeter-level accuracy positioning in real-time.
Tang, Maolin, Maolin Tang
core   +1 more source

Engineering Synergistic Intra‐/Intermolecular Conformational Locking via Side‐Chain Branching: A β‐Sheet‐Inspired Strategy for Planar NIR‐II Phototheranostic Aggregates

Advanced Science, EarlyView.
A bio‐inspired side‐chain branching strategy is developed to orchestrate a dual noncovalent conformational locking (NoCL) network, enabling the construction of perfectly planar NIR‐II phototheranostic aggregates. Such structural precision maximizes light‐harvesting efficiency and optimizes exciton dynamics, ensuring synchronized enhancements in NIR‐II ...
Cheng Lu, Qian Jia, Bo Wu, Chao Li, Ryan T. K. Kwok, Tie‐Gen Chen, Jianwei Sun, Zheng Zhao, Teng‐Teng Chen, Zhongliang Wang, Jacky W. Y. Lam, Ben Zhong Tang   +11 more
wiley   +1 more source