Results 21 to 30 of about 3,369 (139)

QuilA-adjuvanted T. gondii lysate antigens trigger robust antibody and IFNγ+ T cell responses in pigs leading to reduction in parasite DNA in tissues upon challenge infection [PDF]

, 2019
Toxoplasma gondii is an intracellular parasite of all mammals and birds, responsible for toxoplasmosis. In healthy individuals T. gondii infections mostly remain asymptomatic, however this parasite causes severe morbidity and mortality in ...
Cox, Eric, Devriendt, Bert, Dierick, Katelijne, Dorny, Pierre, Gisbert Algaba, Ignacio, Rahman, Mizanur, Verhaegen, Bavo   +6 more
core   +2 more sources

Genome sequence of the parainfluenza virus 5 strain that persistently infects AGS cells [PDF]

, 2016
This work, including the efforts of Richard E Randall, was funded by Wellcome Trust (101788/Z/13/Z). This work, including the efforts of Steve Goodbourn, was funded by Wellcome Trust (101792/Z/13/Z).We have sequenced the parainfluenza virus 5 strain that
Davison, Andrew J., Goodburn, Steve, Randall, Richard Edward, Wignall-Fleming, Elizabeth, Young, Dan Frushard   +4 more
core   +1 more source

Respiratory disease in growing pigs after Porcine rubulavirus experimental infection

Virus Research, 2013
The aim of this study was to analyze the pathogenicity and distribution of Porcine rubulavirus (PorPV) in the respiratory tract of experimentally infected pigs. Nine 6-week-old pigs were infected with PorPV and examined clinically. Blood, nasal swab, and tissue samples were collected on different days post-infection (DPI).
José Francisco, Rivera-Benitez, Sandra, Cuevas-Romero, Armando, Pérez-Torres, Julio, Reyes-Leyva, Jesús, Hernández, Humberto, Ramírez-Mendoza   +5 more
openaire   +2 more sources

Human IFIT1 inhibits mRNA translation of rubulaviruses but not other members of the Paramyxoviridae family [PDF]

, 2016
This work was supported by The Welcome Trust (101788/Z/13/Z, 101792/Z/13/Z) and Medical research council grant (G1100110/1, MR/K024213/1).We have previously shown that IFIT1 is primarily responsible for the antiviral action of interferon (IFN) alpha/beta
Andrejeva, J., Cowling, V. H., Dong, C., Goodbourn, S., Inesta-Vaquera, F., Li, X, Randall, R. E., Young, D. F.   +7 more
core   +4 more sources

Viral hijacking of cellular ubiquitination pathways as an anti-innate immunity strategy. [PDF]

, 2006
International audienceViruses are obligate parasites of host cells. Virus-host coevolution has selected virus for growth despite antiviral defenses set up by hosting cells and organisms. Ubiquitin conjugation onto proteins, through a cascade of reactions
Chen, Mingzhou, Gerlier, Denis
core   +3 more sources

An approach to the control of disease transmission in pig-to-human xenotransplantation. [PDF]

, 2000
: Although several major immunologic hurdles need to be overcome, the pig is currently considered the most likely source animal of cells, tissues and organs for transplantation into humans.
A. D. M. E. Osterhaus, Akiyoshi DE, Alexander TJL, Allan JS, B. W. J. Mahy, Bergelson JM, Bouillant AMP, Butler D, C. Brown, Centers for Disease Control and Prevention., Chang S-F, Cooper DKC, Cooper DKC, Cozzi E, D. K. C. Cooper, D. L. Harris, D. Onions, Dawson M, Dawson M, Doerig RE, Dowdle WR, E. Claassen, Fishman JA, Fishman JA, Fishman JA, Foweraker JE, Galili U, Gibbs Cj, Good AH, Harris DL, Ho M, Hughes JM, Hunter N, Institute of Medicine., J. E. Foweraker, K. Yamanouchi, Lieber MM, Meng X-J, Moennig V, Onions DE, P. D. Minor, P.-P. Pastoret, Patience C, Persing DH, Philbey AW, Rother RP, Rubin RH, Stoye JP, T. J. L. Alexander, Takeuchi Y, Takeuchi Y, Todaro GJ, van der Riet F de St J, Ward T, Webster RG, Wilson CA, Woods WA, Ye Y   +57 more
core   +4 more sources

From conifers to cognition: Microbes, brain and behavior

Genes, Brain and Behavior, Volume 19, Issue 8, November 2020., 2020
A century ago biologists were surprised to discover live microbes (endophytes) within healthy plant tissues. It is now apparent that this is also true of mammals where, in addition to the gut microbiome, a diversity of endogenous microbes (endozoites) are present in multiple tissues including the brain.
Richard Lathe, David St. Clair
wiley   +1 more source

Achimota Pararubulavirus 3: A New Bat-Derived Paramyxovirus of the Genus Pararubulavirus [PDF]

, 2020
Bats are an important source of viral zoonoses, including paramyxoviruses. The paramyxoviral Pararubulavirus genus contains viruses mostly derived from bats that are common, diverse, distributed throughout the Old World, and known to be zoonotic.
Baker, KS, Barr, J, Crameri, G, Crameri, S, Cunningham, AA, Fernandez-Loras, A, Holmes, CEG, Marsh, GA, Smith, I, Suu-Ire, R, Tachedjian, M, Todd, S, Wang, L-F, Wood, JLN   +13 more
core   +8 more sources

Porcine NK cells stimulate proliferation of pseudorabies virus-experienced CD8+ and CD4+ CD8+ T cells [PDF]

, 2018
Natural killer (NK) cells belong to the innate immune system and play a central role in the defense against viral infections and cancer development, but also contribute to shaping adaptive immune responses.
De Pelsmaeker, Steffi, De Regge, Nick, Devriendt, Bert, Favoreel, Herman   +3 more
core   +4 more sources

The switch between acute and persistent paramyxovirus infection caused by single amino acid substitutions in the RNA polymerase P subunit [PDF]

, 2019
Paramyxoviruses can establish persistent infections both in vitro and in vivo, some of which lead to chronic disease. However, little is known about the molecular events that contribute to the establishment of persistent infections by RNA viruses.
Busse, DC, Davison, AJ, Goodbourn, S, Hankinson, J, Lamont, D, Pickin, MJ, Randall, EM, Randall, RE, Tavendale, A, Tregoning, JS, Wignall-Fleming, EB, Young, DF   +11 more
core   +6 more sources