Results 111 to 120 of about 66,699 (304)
BMC Medical Informatics and Decision Making, 2018 Background Despite widespread use, the safety of dietary supplements is open to doubt due to the fact that they can interact with prescribed medications, leading to dangerous clinical outcomes. Electronic health records (EHRs) provide a potential way for
Yadan Fan, Rui Zhang
doaj +1 more source
Detection of epilepsy with Electroencephalogram using rule-based classifiers
Neurocomputing, 2017 Epilepsy is a common neurological disorder, characterized by recurrent seizures. Electroencephalogram (EEG), a useful measure for analysing the brain's electrical activity, has been widely used for the detection of epileptic seizures. Most existing classification techniques are primarily aimed at increasing detection accuracy, while the ...
Guanjin Wang +2 more
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Feature selection for modular GA-based classification
, 2004 Genetic algorithms (GAs) have been used as conventional methods for classifiers to adaptively evolve solutions for classification problems. Feature selection plays an important role in finding relevant features in classification.
Guan, SU, Zhu, F, Zhu, F., Guan, S.
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Российский технологический журнал, 2019 The implementation of the WaldBoost algorithm is considered, and its modification is proposed, which allows to significantly reduce the number of weak classifiers to achieve a given classification accuracy.
A. N. Chesalin +3 more
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Expressive and modular rule-based classifier for data streams [PDF]
, 2019 The advances in computing software, hardware, connected devices and wireless communication infrastructure in recent years have led to the desire to work with streaming data sources. Yet the number of techniques, approaches and algorithms which can work with data from a streaming source is still very limited, compared with batched data.
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source