Results 91 to 100 of about 23,003,325 (298)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Reasoning about context in uncertain pervasive computing environments [PDF]

, 2008
Context-awareness is a key to enabling intelligent adaptation in pervasive computing applications that need to cope with dynamic and uncertain environments.
Zaslavsky, Arkady, Arkady Zaslavsky, Haghighi, P., Krishnaswamy, S., Shonali Krishnaswamy, Gaber, Mohamed Medhat,, Krishnaswamy, Shonali,, Mohamed Medhat Gaber, Gaber, M., Pari Delir Haghighi, Zaslavsky, A., Haghighi, Pari Delir,   +11 more
core   +1 more source

A Recommender System for Educational Planning

Cybernetics and Information Technologies
Knowledge-based recommender systems have always had their privileged place among all Decision Support Systems (DSS), given their advantage on several points over other techniques.
Skittou Mustapha, Merrouchi Mohamed, Gadi Taoufiq   +2 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

The compositional rule of inference with several relations [PDF]

, 1992
The compositional rule of inference with several relations, which is the mainly used inference rule in approximate reasoning, is considered in this paper.
Robert Fullér, Werners, Brigitte, Brigitte Werners, Fullér, Róbert   +3 more
core   +1 more source

TWO APPROACHES TO SOFTWARE FOR PHYSICIAN''S DECISION SUPPORT

Alʹmanah Kliničeskoj Mediciny, 2016
An approach to constructing physician''s decision support systems is presented. This approach allows integrating the rule-based and case-based decision-making.
V. N. Yudin, L. E. Karpov, A. V. Vatazin, A. B. Zulkarnaev   +3 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Intelligent Gearbox Diagnosis Methods Based on SVM, Wavelet Lifting and RBR

Sensors, 2010
Given the problems in intelligent gearbox diagnosis methods, it is difficult to obtain the desired information and a large enough sample size to study; therefore, we propose the application of various methods for gearbox fault diagnosis, including ...
Lixin Gao, Zhiqiang Ren, Wenliang Tang, Huaqing Wang, Peng Chen   +4 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source