Results 51 to 60 of about 50,888 (265)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Sensors, 2023 Epilepsy is a chronic neurological disorder affecting around 1% of the global population, characterized by recurrent epileptic seizures. Accurate diagnosis and treatment are crucial for reducing mortality rates.
Sheng Wong +3 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Robust reasoning: integrating rule-based and similarity-based reasoning
Artificial Intelligence, 1995 Abstract The paper attempts to account for common patterns in commonsense reasoning through integrating rule-based reasoning and similarity-based reasoning as embodied in connectionist models. Reasoning examples are analyzed and a diverse range of patterns is identified.
openaire +1 more source
The Window Validity Problem in Rule-Based Stream Reasoning
CoRR, 2018 Rule-based temporal query languages provide the expressive power and flexibility required to capture in a natural way complex analysis tasks over streaming data. Stream processing applications, however, typically require near real-time response using limited resources.
Ronca, A +3 more
openaire +5 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
IEEE AccessPoster-level relation extraction (PosterRE) identifies spatial and semantic relationships among layout elements. While recent rule-based approaches improve model effectiveness, pipeline methods suffer from error propagation and end-to-end methods risk ...
Peng Chao
doaj +1 more source
Applied Sciences, 2019 Today, patients generate a massive amount of health records through electronic health records (EHRs). Extracting usable knowledge of patients’ pathological conditions or diagnoses is essential for the reasoning process in rule-based systems to ...
Chao Ou-Yang +4 more
doaj +1 more source