Results 61 to 70 of about 21,271 (255)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
RESOLUÇÃO DE PROBLEMAS NA ATENÇÃO AMBULATORIAL DA ESQUIZOFRENIA
Psicologia, 2005 After the psychiatric reformation many families of users of mental health services come to face problems related to ambulatorial settings of treatment.
Mário Gomes de Figueirêdo +1 more
doaj
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Stretched-exponential aging governs nonequilibrium precipitate patterns
Physical Review ResearchLocalized growth in driven materials is often governed by intermittent failure, yet how a material's history biases failure sites remains poorly understood. Using pause-restart experiments on chemical precipitate membranes, we quantify the probability of
Amari Z. Morris, Oliver Steinbock
doaj +1 more source
Is Arabic punctuation rule-governed?
Cogent Arts & HumanitiesThis paper investigates the extent to which Arabic punctuation is rule-governed, with the aim of improving text comprehension, disambiguation, and machine translation.
Sane Yagi +5 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Exploring the relationships between rule-governed behavior and adherence to guidelines aiming to reduce the spread of COVID-19. [PDF]
J Contextual Behav Sci, 2022 Stapleton A, McCloskey C, McHugh L.
europepmc +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Socio-Psychological Structure of Legal Relations
СибСкриптA state governed by the rule of law relies on legal principles recognized and accepted by its society. To determine the socio-psychological structure of legal relations, the author compared the concept of legal relations in Western and Russian legal and ...
D. S. Beznosov
doaj +1 more source