Results 81 to 90 of about 21,271 (255)

Bifurcation of drift wave turbulence trapping by zonal flows near density limit

Nuclear Fusion
We investigate drift wave—zonal flow interactions near the density limit and demonstrate transitions of turbulence trapping states. Nonlinear simulations of the modified Hasegawa–Wakatani model reveal two robust types of turbulence energy localization ...
M. Sasaki, G. Yatomi, Y. Onuki, T. Kobayashi, Y. Kawachi, F. Kin, K. Itoh   +6 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Towards a Generative Frame System of Ancient Chinese Timber Architecture: Structural Generation and Optimization of “Column Reduction” and “Column Relocation”

Buildings
In traditional Chinese timber architecture, “column reduction” (Jian Zhu Zao) and “column relocation” (Yi Zhu Zao) enhances spatial continuity, yet often produces bending-dominated, material-intensive frames. This study develops a generative frame system
Tonghao Liu, Binyue Zhang, Yamin Zhao
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

From LLM narratives to parameterized cooperation policies in multi-agent systems

Frontiers in Artificial Intelligence
IntroductionLarge language models (LLMs) can generate persuasive narratives that shift agent behavior in multi-agent systems, but deploying raw, unstructured text as an influence mechanism offers no formal guarantees on effectiveness, interpretability ...
J. de Curtò, J. de Curtò, J. de Curtò, I. de Zarzà, I. de Zarzà, Jordi Cabot, Jordi Cabot, Pietro Manzoni, Carlos T. Calafate   +8 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Etude préliminaire de la stabilité à l'hydrolyse des polyimides 6F Preliminary Study of the Hydrolysis Stability of 6f Polyimides

Oil & Gas Science and Technology, 2006
L'évaluation comparative du comportement en solution des polylmides 6F fait ressortir que ces nouveaux polymères, doués d'une stabilité thermique élevée par référence à l'analyse thermogravimétrique, ont, par contraste, une résistance beaucoup plus ...
Mileo J. C.
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Theoretical Approaches to the Concept of Legal Relations

СибСкрипт
A state governed by the rule of law establishes balanced legal relations. This article describes four scientific and theoretical approaches to the concept of legal relations, i.e., legal, subject-object, moral, and socio-psychological.
Dmitrii S. Beznosov
doaj   +1 more source