Results 91 to 100 of about 23,484 (271)

GENOMIC VARIABILITY AMONG CATTLE POPULATIONS BASED ON RUNS OF HOMOZYGOSITY

Poljoprivreda, 2015
In this work, the distribution of different lengths ROH (runs of homozygosity) in six cattle breeds was described. A total of 122 animals from six cattle breeds (Holstein, Simmental, Austrian Pinzgau, Ayrshire, MRI-Meuse Rhine Issel and Slovak Pinzgau) were analysed.
Šidlová, Veronika, Kasarda, Radovan, Moravčíková, Nina, Trakovická, Anna, Curik, Ino, Ferenčaković, Maja   +5 more
openaire   +3 more sources

Runs of homozygosity and distribution of functional variants in the cattle genome [PDF]

BMC Genomics, 2015
Recent developments in sequencing technology have facilitated widespread investigations of genomic variants, including continuous stretches of homozygous genomic regions. For cattle, a large proportion of these runs of homozygosity (ROH) are likely the result of inbreeding due to the accumulation of elite alleles from long-term selective breeding ...
Zhang, Qianqian, Guldbrandtsen, Bernt, Bosse, Mirte, Lund, Mogens S., Sahana, Goutam   +4 more
openaire   +5 more sources

Human kin detection [PDF]

, 2015
Natural selection has favored the evolution of behaviors that benefit not only one's genes, but also their copies in genetically related individuals. These behaviors include optimal outbreeding (choosing a mate that is neither too closely related, nor ...
Boklage CE, Daly M, Dawkins R, Holmes WG, Krupp DB, Kurland JA, Platek SM, Thornhill NW, Westermarck E, Wilson EO   +9 more
core   +1 more source

Association of CDKN2A/B Homozygous Deletion and Extent of Resection With Survival of Patients With WHO CNS5 Grade 4 Astrocytoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives WHO grade 4 astrocytomas are associated with poor prognosis, and their prognostic factors remain controversial. This study aimed to identify the prognostic factors and develop a management algorithm for these patients. Methods This study retrospectively included 151 CNS5 adult grade 4 astrocytomas from two medical centers.
Jiawei Cai, Guanglin Zhu, Qiu He, Chen Luo, Lingyun Zhuo, Xingfu Wang, Yiming Chen, Xiaoyong Chen, Wendong You, Jiaheng Xu, Yuanxiang Lin, Dezhi Kang, Shuai Wu, Zanyi Wu   +13 more
wiley   +1 more source

Identification of unique ROH regions with unfavorable effects on production and fertility traits in Canadian Holsteins

Genetics Selection Evolution, 2021
Background The advent of genomic information and the reduction in the cost of genotyping have led to the use of genomic information to estimate genomic inbreeding as an alternative to pedigree inbreeding.
Bayode O. Makanjuola, Christian Maltecca, Filippo Miglior, Gabriele Marras, Emhimad A. Abdalla, Flavio S. Schenkel, Christine F. Baes   +6 more
doaj   +1 more source

The Structure of Allelic Diversity in the Presence of Purifying Selection [PDF]

, 2012
In the absence of selection, the structure of equilibrium allelic diversity is described by the elegant sampling formula of Ewens. This formula has helped shape our expectations of empirical patterns of molecular variation.
Desai, Michael M, Nicolaisen, Lauren Elisabeth, Plotkin, Joshua B., Walczak, Aleksandra M.   +3 more
core   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Analysis of Runs of Homozygosity in Aberdeen Angus Cattle

Animals
A large number of cattle breeds have marked phenotypic differences. They are valuable models for studying genome evolution. ROH analysis can facilitate the discovery of genomic regions that may explain phenotypic differences between breeds affecting traits of economic importance. This paper investigates genome-wide ROH of 189 Aberdeen Angus bulls using
Vladimir Kolpakov, Alexey Ruchay, Dianna Kosyan, Elena Bukareva   +3 more
openaire   +3 more sources

Runs of homozygosity: windows into population history and trait architecture

Nature Reviews Genetics, 2018
Long runs of homozygosity (ROH) arise when identical haplotypes are inherited from each parent and thus a long tract of genotypes is homozygous. Cousin marriage or inbreeding gives rise to such autozygosity; however, genome-wide data reveal that ROH are universally common in human genomes even among outbred individuals.
Ceballos, Francisco C., Joshi, Peter, Clark, David, Ramsay, Michele, Wilson, James   +4 more
openaire   +4 more sources

Estimates of genomic inbreeding and identification of candidate regions that differ between Chinese indigenous sheep breeds

Journal of Animal Science and Biotechnology, 2021
Background A run of homozygosity (ROH) is a consecutive tract of homozygous genotypes in an individual that indicates it has inherited the same ancestral haplotype from both parents. Genomic inbreeding can be quantified based on ROH.
Jiaxin Liu, Liangyu Shi, Yang Li, Liang Chen, Dorian Garrick, Lixian Wang, Fuping Zhao   +6 more
doaj   +1 more source