Results 121 to 130 of about 23,484 (271)

Genomic Inbreeding and Runs of Homozygosity Analysis of Cashmere Goat

Animals
Cashmere goats are valuable genetic resources which are famous worldwide for their high-quality fiber. Runs of homozygosity (ROHs) have been identified as an efficient tool to assess inbreeding level and identify related genes under selection. However, there is limited research on ROHs in cashmere goats.
Qian Zhao, Chang Huang, Qian Chen, Yingxiao Su, Yanjun Zhang, Ruijun Wang, Rui Su, Huijuan Xu, Shucai Liu, Yuehui Ma, Qianjun Zhao, Shaohui Ye   +11 more
openaire   +3 more sources

OVAS: an open-source variant analysis suite with inheritance modelling

BMC Bioinformatics, 2018
Background The advent of modern high-throughput genetics continually broadens the gap between the rising volume of sequencing data, and the tools required to process them.
Monika Mozere, Mehmet Tekman, Jameela Kari, Detlef Bockenhauer, Robert Kleta, Horia Stanescu   +5 more
doaj   +1 more source

detectRUNS: Detect runs of homozygosity and runs of heterozygosity in diploid genomes [PDF]

, 2018
detectRUNS is a R package for the detection of runs of homozygosity (ROH/ROHom) and of heterozygosity (ROHet, a.k.a. “heterozygosity-rich regions”) in diploid genomes. ROH/ROHom were first studied in humans (e.g. McQuillan et al.
Biscarini, Filippo, Cozzi, Paolo, Gaspa, Giustino, Marras, Gabriele   +3 more
core   +1 more source

MDP25‐VDAC3 Complex Orchestrates Actin Remodeling and Mitochondrial Dynamics to Modulate Innate Immunity in Arabidopsis

Advanced Science, EarlyView.
This study reveals that actin remodeling regulates mitochondrial elongation as a defense strategy in plants. Flagellin perception induces fusion‐dependent elongation, supported by cortical actin bundles, to repair damage and boost ATP and ROS production.
Junxiu Hou, Pengfei Lu, Xuan Cui, Liangfeng Luo, Qing Pan, Jiejie Li   +5 more
wiley   +1 more source

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

Runs of homozygosity and parental relatedness [PDF]

Genetics in Medicine, 2013
Noah A, Rosenberg, Trevor J, Pemberton, Jun Z, Li, John W, Belmont   +3 more
openaire   +2 more sources

Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer

Advanced Science, EarlyView.
Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.
John D. Martin, Koji Nagaoka, Myrofora Panagi, Akihiro Hosoi, Fotios Mpkeris, Pengwen Chen, Thahomina T. Khan, Margaret R. Martin, Changbo Sun, Chrysovalantis Voutouri, Maria Louca, Panagiotis Papageorgis, Akira Sumiyoshi, Nobuhiro Nitta, Kazuyoshi Takeda, Ichio Aoki, Kazunori Kataoka, Triantafyllos Stylianopoulos, Kazuhiro Kakimi, Horacio Cabral   +19 more
wiley   +1 more source

Runs of Homozygosity and Epigenetic Deregulation of Genomic Imprinting

OBM Genetics, 2018
Runs of homozygosity (ROH) are uninterrupted contiguous regions within the genome exhibiting allelic homozygosity (alleles are inherited from the same parent). Genome-wide analyses consistently demonstrate that megabase-scale ROH are ubiquitous in humans, reflecting individual demographic history.
Ivan Y. Iourov, Svetlana G. Vorsanova, Yuri B. Yurov   +2 more
openaire   +1 more source

Comparative genome-wide analysis of Ovis aries in Saudi Arabia highlighting inbreeding and genetic isolation of the Najdi sheep breed

Frontiers in Genetics
IntroductionSheep (Ovis aries) farming through traditional practices plays a vital role in the socio-economic development of the Kingdom of Saudi Arabia (KSA). Genetic relationships among KSA sheep breeds remain poorly characterized.MethodsIn this study,
Abdulrahman K. Aldawish, Abdulrahman K. Aldawish, Abdulrahman K. Aldawish, Mohanad A. Ibrahim, Mohanad A. Ibrahim, Faisal M. Alsubaie, Faisal M. Alsubaie, Faisal M. Alsubaie, Quaiser Saquib, Mohammed Fahad Albeshr   +9 more
doaj   +1 more source