Results 11 to 20 of about 23,484 (271)
Runs of Homozygosity in European Populations [PDF]
The American Journal of Human Genetics, 2008 Estimating individual genome-wide autozygosity is important both in the identification of recessive disease variants via homozygosity mapping and in the investigation of the effects of genome-wide homozygosity on traits of biomedical importance. Approaches have tended to involve either single-point estimates or rather complex multipoint methods of ...McQuillan, Ruth, Leutenegger, Anne-Louise, Abdel-Rahman, Rehab, Franklin, Christopher S, Pericic, Marijana, Barac-Lauc, Lovorka, Smolej-Narancic, Nina, Janicijevic, Branka, Polasek, Ozren, Tenesa, Albert, Macleod, Andrew K, Farrington, Susan M, Rudan, Pavao, Hayward, Caroline, Vitart, Veronique, Rudan, Igor, Wild, Sarah H, Dunlop, Malcolm G, Wright, Alan F, Campbell, Harry, Wilson, James F +20 more +9 more sourcesRuns of homozygosity and analysis of inbreeding depression [PDF]
Journal of Animal Science, 2020 Abstract Pedigree information was traditionally used to assess inbreeding. The availability of high-density marker panels provides an alternative to assess inbreeding, particularly in the presence of incomplete and error-prone pedigrees.Pattarapol Sumreddee, Sajjad Toghiani, El Hamidi Hay, Andrew Roberts, Samuel E Aggrey, Romdhane Rekaya +5 moreopenaire +3 more sourcesLong runs of homozygosity are associated with Alzheimer’s disease [PDF]
Translational Psychiatry, 2021 AbstractLong runs of homozygosity (ROH) are contiguous stretches of homozygous genotypes, which are a footprint of inbreeding and recessive inheritance. The presence of recessive loci is suggested for Alzheimer’s disease (AD); however, their search has been poorly assessed to date.Sonia Moreno-Grau, Maria Victoria Fernández, Itziar de Rojas, Pablo Garcia-González, Isabel Hernández, Fabiana Farias, John P. Budde, Inés Quintela, Laura Madrid, Antonio González-Pérez, Laura Montrreal, Emilio Alarcón-Martín, Montserrat Alegret, Olalla Maroñas, Juan Antonio Pineda, Juan Macías, C. Abdelnour, N. Aguilera, E. Alarcón-Martín, M. Alegret, A. Benaque, M. Boada, M. Buendía, P. Cañabate, A. Carracedo, A. Corbatón, I. de Rojas, S. Diego, A. Espinosa, A. Gailhajenet, P. García González, S. Gil, M. Guitart, A. González Pérez, I. Hernández, M. Ibarria, A. Lafuente, J. Macías, O. Maroñas, E. Martín, M. T. Martínez, M. Marquié, A. Mauleón, G. Monté-Rubio, L. Montrreal, S. Moreno-Grau, M. Moreno, A. Orellana, G. Ortega, A. Pancho, E. Pelejà, A. Pérez-Cordon, J. A. Pineda, S. Preckler, I. Quintela, L. M. Real, O. Rodríguez-Gómez, M. Rosende-Roca, A. Ruiz, S. Ruiz, M. E. Sáez, A. Sanabria, M. A. Santos-Santos, M. Serrano-Ríos, O. Sotolongo-Grau, L. Tárraga, S. Valero, L. Vargas, A. D. Adarmes-Gómez, E. Alarcón-Martín, I. Álvarez, V. Álvarez, G. Amer-Ferrer, M. Antequera, C. Antúnez, M. Baquero, M. Bernal, R. Blesa, M. Boada, D. Buiza-Rueda, M. J. Bullido, J. A. Burguera, M. Calero, F. Carrillo, M. Carrión-Claro, M. J. Casajeros, J. Clarimón, J. M. Cruz-Gamero, M. M. de Pancorbo, I. de Rojas, T. del Ser, M. Diez-Fairen, J. Fortea, E. Franco, A. Frank-García, J. M. García-Alberca, S. García Madrona, G. Garcia-Ribas, P. Gómez-Garre, I. Hernández, S. Hevilla, S. Jesús, M. A. Labrador Espinosa, C. Lage, A. Legaz, A. Lleó, A. López de Munáin, S. López-García, D. Macías, S. Manzanares, M. Marín, J. Marín-Muñoz, T. Marín, M. Marquié, A. Martín-Montes, B. Martínez, C. Martínez, V. Martínez, P. Martínez-Lage Álvarez, M. Medina, M. Mendioroz Iriarte, M. Menéndez-González, P. Mir, J. L. Molinuevo, L. Montrreal, S. Moreno-Grau, A. Orellana, A. B. Pastor, P. Pastor, J. Pérez-Tur, T. Periñán-Tocino, G. Piñol-Ripoll, A. Rábano, D. Real de Asúa, S. Rodrigo, E. Rodríguez-Rodríguez, J. L. Royo, A. Ruiz, R. Sanchez del Valle Díaz, P. Sánchez-Juan, I. Sastre, O. Sotolongo-Grau, L. Tárraga, S. Valero, M. P. Vicente, L. Vivancos, Marta Marquié, Sergi Valero, Alba Benaque, Jordi Clarimón, Maria Jesus Bullido, Guillermo García-Ribas, Pau Pástor, Pascual Sánchez-Juan, Victoria Álvarez, Gerard Piñol-Ripoll, Jose María García-Alberca, José Luis Royo, Emilio Franco-Macías, Pablo Mir, Miguel Calero, Miguel Medina, Alberto Rábano, Jesús Ávila, Carmen Antúnez, Luis Miguel Real, Adelina Orellana, Ángel Carracedo, María Eugenia Sáez, Lluís Tárraga, Mercè Boada, Carlos Cruchaga, Agustín Ruiz +172 moreopenaire +16 more sourcesEthnic Identity and Genome Wide Runs of Homozygosity [PDF]
Behavior Genetics, 2021 AbstractIt is long known that inbreeding increases the detrimental effects of recessive sequence variants in “Runs of Homozygosity” (ROHs). However, although the phenotypic association of ROH has been investigated for a variety of traits, the statistical power of the results often remains limited as a sufficiently high number of cases are available for Fieder, Martin, Mitchell, Brittany L., Gordon, Scott, Huber, Susanne, Martin, Nicholas G. +4 moreopenaire +5 more sourcesRuns of homozygosity and testicular cancer risk [PDF]
Andrology, 2019 AbstractBackgroundTesticular germ cell tumour (TGCT) is highly heritable but > 50% of the genetic risk remains unexplained. Epidemiological observation of greater relative risk to brothers of men with TGCT compared to sons has long alluded to recessively acting TGCT genetic susceptibility factors, but to date none have been reported.Loveday, C., Sud, A., Litchfield, K., Levy, M., Holroyd, A., Broderick, P., Kote-Jarai, Z., Dunning, A.M., Muir, K., Peto, J., Eeles, R., Easton, D.F., Dudakia, D., Orr, N., Pashayan, N., Rustin, Gordon, Srihari, Narayanan N., Cole, David, Askill, Colin, Bertelli, Gianfilippo, Barber, James, Gilby, Ed, White, Jeff, Baybrooke, Jeremy, Leahy, Michael, Welch, Richard, Chakraborti, Prabir, Joffe, Johnathan, Brown, Richard, Faust, Guy, Simmonds, Peter, Mazhar, Danish, Stockdale, Andrew, Hrounda, David, Humber, Caroline, Appel, Wiebke, Hong, Anne, Howard, Grahame, Douglas, Fiona, Bloomfield, David, Butt, Mohammad, Kelly, Kay, Mehra, Rakesh, Brown, Richard, Rogers, Paul, Chakraborti, Prabir, Hatton, Matthew, Hennig, Ivo, McAteer, John, Savage, Philip, Seckl, Michael, Gale, Joanna, Rustin, Gordon, Clark, Peter, Woby, Steve, Rathmell, Adrian, Lamont, Alan, Sarwar, Naveed, Stuart, Nick, Chowdhury, Simon, Beesley, Sharon, Winkler, Mathius, Hamid, Abdel, Pathak, Sanjeev, Madhavan, Krishnaswamy, Highley, Martin, Money-Kryle, Julian, Brock, Cathryn, Sreenivasan, Thiagarajan, Henderson, Brian E., Haiman, Christopher A., Schumacher, Fredrick R., Al Olama, Ali Amin, Benlloch, Sara, Berndt, Sonja I., Conti, David V., Wiklund, Fredrik, Chanock, Stephen, Gapster, Susan, Stevens, Victoria L., Tangen, Catherine M., Batra, Jyotsna, Clements, Judith, Gronberg, Henrik, Schleutker, Johanna, Albanes, Demetrius, Wolk, Alicja, West, Catharine, Mucci, Lorelei, Cancel-Tassin, Geraldine, Koutros, Stella, Sorensen, Karina Dalsgaard, Maehle, Lovise, Neal, David E., Hamdy, Freddie C., Donovan, Jenny L., Travis, Ruth C., Hamilton, Robert J., Ingles, Sue Ann, Rosenstein, Barry S., Lu, Yong-Jie, Giles, Graham G., Kibel, Adam S., Vega, Ana, Kogevinas, Manolis, Penney, Kathryn L., Park, Jong Y., Stanford, Janet L., Cybulski, Cezary, Nordestgaard, Borge G., Brenner, Hermann, Maier, Christiane, Kim, Jeri, John, Esther M., Teixeira, Manuel R., Neuhausen, Susan L., De Ruyck, Kim, Razack, Azad, Newcomb, Lisa F., Lessel, Davor, Kaneva, Radka, Usmani, Nawaid, Claessens, Frank, Townsend, Paul A., Dominguez, Manuela Gago, Roobol, Monique J., Menegaux, Florence, Khaw, Kay-Tee, Cannon-Albrigh, Lisa, Pandha, Hardev, Thibodeau, Stephen N., Reid, A., Huddart, R.A., Houlston, R.S., Turnbull, C. +134 moreopenaire +4 more sourcesGenomic prediction based on runs of homozygosity [PDF]
Genetics Selection Evolution, 2014 Genomic prediction is based on the accurate estimation of the genomic relationships among and between training animals and selection candidates in order to obtain accurate estimates of the genomic estimated breeding values (GEBV). Various methods have been used to predict GEBV based on population-wide linkage disequilibrium relationships (G IBS ) or ...Luan T., Yu X., Dolezal M., Bagnato A., Meuwissen T. H. +4 moreopenaire +3 more sourcesRuns of homozygosity and population history in cattle [PDF]
BMC Genetics, 2012 Abstract Background Runs of homozygosity (ROH) are contiguous lengths of homozygous genotypes that are present in an individual due to parents transmitting identical haplotypes to their offspring. The extent and frequency of ROHs may inform on the ancestry of an individual and its population. Here we use high density (Purfield, Deirdre C, Berry, Donagh, McParland, Sinead, Bradley, Daniel G +3 moreopenaire +6 more sources
