Results 41 to 50 of about 23,484 (271)

Genomic Diversity and Runs of Homozygosity in Bernese Mountain Dogs

Genes, 2023
Bernese mountain dogs are a large dog breed formed in the early 1900s in Switzerland. While originally farm dogs that were used for pulling carts, guarding, and driving cattle, today they are considered multi-purpose companion and family dogs. The breed is predisposed to several complex diseases, such as histiocytic sarcoma, degenerative myelopathy, or
Anna Letko, Benoît Hédan, Anna Snell, Alexander C. Harris, Vidhya Jagannathan, Göran Andersson, Bodil S. Holst, Elaine A. Ostrander, Pascale Quignon, Catherine André, Tosso Leeb   +10 more
openaire   +4 more sources

Inbreeding depression across the genome of Dutch Holstein Friesian dairy cattle

Genetics Selection Evolution, 2020
Background Inbreeding depression refers to the decrease in mean performance due to inbreeding. Inbreeding depression is caused by an increase in homozygosity and reduced expression of (on average) favourable dominance effects.
Harmen P. Doekes, Piter Bijma, Roel F. Veerkamp, Gerben de Jong, Yvonne C. J. Wientjes, Jack J. Windig   +5 more
doaj   +1 more source

Rare primary dyslipidaemias associated with low LDL and HDL cholesterol values in Portugal

Frontiers in Genetics, 2023
Background: Dyslipidaemia represents a group of disorders of lipid metabolism, characterized by either an increase or decrease in lipid particles, usually associated with triglycerides, LDL cholesterol (LDL-C) and/or HDL cholesterol (HDL-C).
Ana Catarina Alves, Ana Catarina Alves, Beatriz Miranda, Beatriz Miranda, Oana Moldovan, Raquel Espírito Santo, Raquel Gouveia Silva, Sandra Soares Cardoso, Luísa Diogo, Mónica Seidi, Mónica Seidi, Silvia Sequeira, Mafalda Bourbon, Mafalda Bourbon   +13 more
doaj   +1 more source

Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain. [PDF]

, 2009
Alpha-synuclein (SNCA) gene has been implicated in the development of rare forms of familial Parkinson disease (PD). Recently, it was shown that an increase in SNCA copy numbers leads to elevated levels of wild-type SNCA-mRNA and protein and is ...
Bernard, David J, Chiba-Falek, Ornit, Cronin, Kenneth D, El-Agnaf, Omar MA, Ge, Dongliang, Linnertz, Colton, Manninger, Paul, Nussbaum, Robert L, Orrison, Bonnie M, Rossoshek, Anna, Schlossmacher, Michael G   +10 more
core   +2 more sources

Runs of Homozygosity Do Not Influence Survival to Old Age [PDF]

PLoS ONE, 2011
Runs of homozygosity (ROH) are extended tracts of adjacent homozygous single nucleotide polymorphisms (SNPs) that are more common in unrelated individuals than previously thought. It has been proposed that estimating ROH on a genome-wide level, by making use of the genome-wide single nucleotide polymorphism (SNP) data, will enable to indentify ...
Kuningas, Maris, McQuillan, Ruth, Wilson, James F, Hofman, Albert, van Duijn, Cornelia M, Uitterlinden, André G, Tiemeier, Henning   +6 more
openaire   +5 more sources

Hitchhiking Mapping of Candidate Regions Associated with Fat Deposition in Iranian Thin and Fat Tail Sheep Breeds Suggests New Insights into Molecular Aspects of Fat Tail Selection

Animals, 2022
The fat tail is a phenotype that divides indigenous Iranian sheep genetic resources into two major groups. The objective of the present study is to refine the map location of candidate regions associated with fat deposition, obtained via two separate ...
Mohammad Hossein Moradi, Ardeshir Nejati-Javaremi, Mohammad Moradi-Shahrbabak, Ken G. Dodds, Rudiger Brauning, John C. McEwan   +5 more
doaj   +1 more source

Genomic Analysis Reveals Specific Patterns of Homozygosity and Heterozygosity in Inbred Pigs

Animals, 2019
The inbred strain of miniature pig is an ideal model for biomedical research due to its high level of homozygosity. In this study, we investigated genetic diversity, relatedness, homozygosity, and heterozygosity using the Porcine SNP60K BeadChip in both ...
Ligang Wang, Yulian Mu, Linyang Xu, Kui Li, Jianlin Han, Tianwen Wu, Lan Liu, Qian Gao, Ying Xia, Guanyu Hou, Shulin Yang, Xiaohong He, George E. Liu, Shutang Feng   +13 more
doaj   +1 more source

The bracteatus pineapple genome and domestication of clonally propagated crops [PDF]

, 2019
Domestication of clonally propagated crops such as pineapple from South America was hypothesized to be a 'one-step operation'. We sequenced the genome of Ananas comosus var.
Alonge, Michael, Bennetzen, Jeffrey L., Boches, Peter, Chen, Li-Yu, Chen, Shuai, Choi, Jae Young, Coppens D'Eeckenbrugge, Geo, Cushman, John C., Fatima, Mahpara, Huang, Lixian, Hwa, Teh-Yang, Kao, Shu-Min, Lexer, Christian, Liao, Zhenyang, Lin, Jishan, Lin, Zhicong, Liu, Juan, Matsumoto, Tracie, Ming, Ray, Paris, Margot, Paull, Robert E., Purugganan, Michael D., Qin, Yuan, Ramakrishnan, Srividya, Sanewski, Garth M., Schatz, Michael C., Sharma, Anupma, Song, Jian, Tung, Chih-Wei, VanBuren, Robert, Wai, Ching Man, Wang, Hao, Wang, Jianping, Wang, Lulu, Wang, Ming-Li, Wu, Jun, Wu, Qingsong, Yan, Hansong, Yim, Won C., Yu, Qingyi, Yue, Jingjing, Zhang, Jisen, Zhang, Shaoling, Zhang, Xingtan, Zhou, Hongye   +44 more
core   +5 more sources

Sequence Polymorphisms and Structural Variations among Four Grapevine (Vitis vinifera L.) Cultivars Representing Sardinian Agriculture

Frontiers in Plant Science, 2017
The genetic diversity among grapevine (Vitis vinifera L.) cultivars that underlies differences in agronomic performance and wine quality reflects the accumulation of single nucleotide polymorphisms (SNPs) and small indels as well as larger genomic ...
Luca Mercenaro, Giovanni Nieddu, Andrea Porceddu, Mario Pezzotti, Salvatore Camiolo   +4 more
doaj   +1 more source

Assessing runs of homozygosity reveals production traits of Kazakh sheep breeds [PDF]

Brazilian Journal of Biology
Sheep breeding in Kazakhstan is one of the main local roles in animal husbandry. This article presents the results of a study of the genetic indicators of sheep breeds in Kazakhstan, in relation to their meat and wool productivity.
A. Khamzina, D. Smagulov, K. Dossybayev, J. Kantanen, K. Khamzin   +4 more
doaj   +1 more source