Results 61 to 70 of about 23,484 (271)

Assessing molecular variability in cancer genomes [PDF]

, 2010
The dynamics of tumour evolution are not well understood. In this paper we provide a statistical framework for evaluating the molecular variation observed in different parts of a colorectal tumour.
Barbour, A. D., Tavaré, Simon
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Wolf outside, dog inside? The genomic make-up of the Czechoslovakian Wolfdog [PDF]

, 2018
Background Genomic methods can provide extraordinary tools to explore the genetic background of wild species and domestic breeds, optimize breeding practices, monitor and limit the spread of recessive diseases, and discourage illegal crossings.
Bolf\uedkov\ue1, Barbora \u10cern\ue1, Camatta, Alessio, Caniglia, Romolo, Carnier, Paolo, Dykyy, Ihor, Fabbri, Elena, Galaverni, Marco, Hulva, Pavel, Jind\u159ichov\ue1, Milena, Randi, Ettore, Stronen, Astrid Vik   +10 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Genomic approach to manage genetic variability in dairy farms

Italian Journal of Animal Science, 2023
In this study we investigated the genetic variability, the inbreeding and allele frequencies of monogenic traits in seven herds of Holstein breed and provided insight to farmers on the value of genomic management of reproduction in their herds.
Chiara Punturiero, Raffaella Milanesi, Francesca Bernini, Andrea Delledonne, Alessandro Bagnato, Maria Giuseppina Strillacci   +5 more
doaj   +1 more source

Considerate Approaches to Achieving Sufficiency for ABC model selection

, 2011
For nearly any challenging scientific problem evaluation of the likelihood is problematic if not impossible. Approximate Bayesian computation (ABC) allows us to employ the whole Bayesian formalism to problems where we can use simulations from a model ...
Chris Barnes, Michael Stumpf, Michael Stumpf, Sarah Filippi, Tom Thorne   +4 more
core   +1 more source

Exploring the relationship between tychoparthenogenesis and inbreeding depression in the Desert Locust, Schistocerca gregaria [PDF]

, 2017
Tychoparthenogenesis, a form of asexual reproduction in which a small proportion of unfertilized eggs can hatch spontaneously, could be an intermediate evolutionary link in the transition from sexual to parthenogenetic reproduction.
Blondin, Laurence, Chapuis, Elodie, Chapuis, Marie Pierre, Jourdan, Hélène, Little, Chelsea   +4 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Runs of Homozygosity Implicate Autozygosity as a Schizophrenia Risk Factor

PLoS Genetics, 2012
Autozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but also occurs at lower levels among the offspring of distantly related mates. Here, we use runs of homozygosity in genome-wide SNP data to
Keller, Matthew C., Simonson, Matthew A., Ripke, Stephan, Neale, Ben M., Gejman, Pablo V., Howrigan, Daniel P., Lee, Sang Hong, Lencz, Todd, Levinson, Douglas F., Sullivan, Patrick F., St Clair, David, Cichon, Sven, Rietschel, Marcella, Nöthen, Markus M., Maier, Wolfgang, Schulze, Thomas G., Mattheisen, Manuel, Kirov, George K., O'Donovan, Michael C., Holmans, Peter A., Georgieva, Lyudmila, Nikolov, Ivan, Williams, Hywel J., Toncheva, Draga, Milanova, Vihra, Owen, Michael J., Craddock, Nicholas, Hamshere, Marian, Moskvina, Valentina, Dwyer, Sarah, Zammit, Stan, Lin, Dan-Yu, van den Oord, Edwin, Kim, Yunjung, Stroup, T. Scott, Lieberman, Jeffrey A., Hansen, Thomas, Ingason, Andrés, Olsen, Line, Schmock, Henriette, Skjødt, Celina, Thygesen, Johan Hilge, Rosengren, Anders, Werge, Thomas, Morris, Derek W., O'Dushlaine, Colm T., Kenny, Elaine, Quinn, Emma M., Linszen, Don H., de Haan, Lieuwe   +49 more
openaire   +10 more sources

Runs of Homozygosity in Modern Chicken Revealed by Sequence Data

G3 Genes|Genomes|Genetics, 2020
Abstract Runs of homozygosity (ROH) are chromosomal stretches that in a diploid genome appear in a homozygous state and display identical alleles at multiple contiguous loci. This study aimed to systematically compare the genomic distribution of the ROH islands among five populations of wild vs.
Reza Talebi, Tomasz Szmatoła, Gábor Mészáros, Saber Qanbari   +3 more
openaire   +3 more sources