Results 91 to 100 of about 286,800 (345)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
The Influence of runner system on production of injection molds
MATEC Web of Conferences, 2016 This experimental study describes the influence of runner system on rheological properties during the injection molding process. Economic effects on the amount of production are discussed as well.
Janostik Vaclav +4 more
doaj +1 more source
Solemate: A Music App for Runners [PDF]
, 2019 Solemate is a mobile application designed to enhance the running experience through music. Our feed-forward algorithm sets the runner’s pace by playing music that varies in tempo.
Jujara, Arshi +2 more
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Effect of Intercropping System on the Quality and Quantity of Runner Bean (Phaseolus coccineus L.)
Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2016 Field experiments were conducted two consecutive years, in order to investigate runner bean (Phaseolus coccineus L.) cultivated in pure crop system and in intercropping system.
Silvia Brîndușa HAMBURDĂ +3 more
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
ANALISA ALIRAN FLUIDA PADA INTAKE MANIFOLD MOBIL ESEMKA STANDAR DENGAN INTAKE MANIFOLD MODIFIKASI MENGGUNAKAN CFD (Computational Fluid Dynamis) PADA SOFTWARE ANSYS 15.0 [PDF]
, 2015 Intake manifold merupakan salah satu komponen yang sangat penting. Fungsi intake manifold adalah untuk menghantar udara ke silinder atau ruang bakar, posisi dan sudut belokan pada runner sangat berpengaruh terhadap kesempurnaan pencampuran bahan bakar ...
, Ir. H. Sarjito, MT, Ph.D +2 more
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