Results 71 to 80 of about 2,026 (216)

The Influence of runner system on production of injection molds

MATEC Web of Conferences, 2016
This experimental study describes the influence of runner system on rheological properties during the injection molding process. Economic effects on the amount of production are discussed as well.
Janostik Vaclav, Stanek Michal, Manas David, Manas Miroslav, Senkerik Vojtech   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Effect of Intercropping System on the Quality and Quantity of Runner Bean (Phaseolus coccineus L.)

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2016
Field experiments were conducted two consecutive years, in order to investigate runner bean (Phaseolus coccineus L.) cultivated in pure crop system and in intercropping system.
Silvia Brîndușa HAMBURDĂ, Neculai MUNTEANU, Vasile STOLERU, Gabriel Ciprian TELIBAN   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Reference Values for Hydration Biomarkers: Optimizing Athletic Performance and Recovery

Open Access Journal of Sports Medicine
Lawrence E Armstrong,1 Rebecca L Stearns,1 Robert A Huggins,1 Yasuki Sekiguchi,2 April J Mershon,3 Douglas J Casa1 1Department of Kinesiology, Korey Stringer Institute, University of Connecticut, Storrs, CT, 06269-1110, USA; 2Department of Kinesiology ...
Armstrong LE, Stearns RL, Huggins RA, Sekiguchi Y, Mershon AJ, Casa DJ   +5 more
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Dynamic equation and response of turbine runner blade under flow excitation

Advances in Mechanical Engineering, 2018
Considering the complex vibration phenomenon of turbine runner blades under the flow excitation, the nonlinear coupling dynamic equation, which contains hydraulic parameters and blade structure parameters, is established by the finite element method ...
Zhaojun Li, Xing Heng, Tinghao Li, Yujiang Wang, Hongyu Wang   +4 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Strawberry Plant Propagation: Evaluation of Cultivars Using Different Growing Environments and Assessment Approaches

HortScience
Strawberry branch crown development is often associated with yield and berry size. The propagation rate of strawberry cultivars is key to their establishment and longevity in the industry.
Kim S. Lewers, Bryan T. Vinyard
doaj   +1 more source