Results 81 to 90 of about 267,041 (297)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Experimental and Numerical Studies on a Centrifugal Pump with 2D-Curved Blades in Cavitating Condition [PDF]

, 2001
In the presented study a special test-pump with 2D curvature blade geometry in cavitating and non-cavitating conditions was investigated using different experimental techniques and a 3D numerical model of cavitating flows.
Coutier-Delgosha, O., Fortes-Patella, R., Hofmann, M., Reboud, J.L., Stoffel, B.   +4 more
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Factors Controlling Runner Formation in Strawberries

Agronomy
Strawberry propagation relies predominantly on asexual reproduction via runner plants, making runners a critical organ for cultivation. Runners develop from axillary buds under specific environmental conditions.
Yali Li, Byoung Ryong Jeong, Ping Huang, Xia Qiu, Feiyu Zhu, Jiaxian He, Liang Zhao, Si Wang, Xin Meng, Mingzhong Ding   +9 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Identification of hydro-turbine runner with cracked blade based on power spectral density transmissibility in operation

Engineering Applications of Computational Fluid Mechanics
For peaking hydropower plants, the damage to the runner blades is a common problem. Real-time online detection of runner blade damage can effectively prevent major accidents in the hydropower unit. However, the online monitoring of runner status is still
Juan Duan, Jun Huang, Zeyu Peng, Luyang Chen, Jing Qian, Yun Zeng   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

ANALISA ALIRAN FLUIDA PADA INTAKE MANIFOLD MOBIL ESEMKA STANDAR DENGAN INTAKE MANIFOLD MODIFIKASI MENGGUNAKAN CFD (Computational Fluid Dynamis) PADA SOFTWARE ANSYS 15.0 [PDF]

, 2015
Intake manifold merupakan salah satu komponen yang sangat penting. Fungsi intake manifold adalah untuk menghantar udara ke silinder atau ruang bakar, posisi dan sudut belokan pada runner sangat berpengaruh terhadap kesempurnaan pencampuran bahan bakar ...
, Ir. H. Sarjito, MT, Ph.D, , Nur Aklis, ST, M.Eng, Syah, Agus Pranoto   +2 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The Influence of runner system on production of injection molds

MATEC Web of Conferences, 2016
This experimental study describes the influence of runner system on rheological properties during the injection molding process. Economic effects on the amount of production are discussed as well.
Janostik Vaclav, Stanek Michal, Manas David, Manas Miroslav, Senkerik Vojtech   +4 more
doaj   +1 more source