Results 261 to 270 of about 66,303 (295)

Signaling networks in RUNX2‐dependent bone development

Journal of Cellular Biochemistry, 2011
AbstractRUNX2 is an essential transcription factor for osteoblast differentiation and chondrocyte maturation. SP7, another transcription factor, is required for osteoblast differentiation. Major signaling pathways, including FGF, Wnt, and IHH, also play important roles in skeletal development.
Toshihisa Komori
exaly   +3 more sources

RUNX2 Quadruplication

Journal of Craniofacial Surgery, 2013
The RUNX2 transcription factor regulates osteoblast differentiation. Its absence, as with cleidocranial dysplasia, results in deficient bone formation. However, its excess seems to follow a dose response of over ossification. RUNX2 duplications (3 copies) are exceedingly rare but have been reported to cause craniosynostosis.
Matthew R, Greives, Eric A, Odessey, Darrel J, Waggoner, Deana S, Shenaq, Swaroop, Aradhya, Allison, Mitchell, Emma, Whitcomb, Neil, Warshawsky, Tong-Chuan, He, Russell R, Reid   +9 more
openaire   +2 more sources

Advances in Runx2 regulation and its isoforms

Medical Hypotheses, 2007
During the last 10 years, we have witnessed major progress in skeleton biology. Runx2 is an accepted transcription factor essential for osteoblast development from mesenchymal stem cells and maturation into osteocytes and organize crucial events during bone formation. Alternations in Runx2 expression levels are associated with skeletal diseases.
Ya-Lin, Li, Zhou-Sheng, Xiao
openaire   +2 more sources

PCAF acetylates Runx2 and promotes osteoblast differentiation

Journal of Bone and Mineral Metabolism, 2013
Osteoblasts play a crucial role in bone formation. However, the molecular mechanisms involved in osteoblast differentiation remain largely unclear. Runt-related gene 2 (Runx2) is a master transcriptional factor for osteoblast differentiation. Here we reported that p300/CBP-associated factor (PCAF) directly binds to Runx2 and acetylates Runx2, leading ...
Chao-Yang, Wang, Shu-Feng, Yang, Zhong, Wang, Jun-Ming, Tan, Shun-Min, Xing, De-Chun, Chen, Sheng-Ming, Xu, Wen, Yuan   +7 more
openaire   +2 more sources

Microtubule‐dependent nuclear‐cytoplasmic shuttling of Runx2

Journal of Cellular Physiology, 2005
AbstractRUNX/AML transcription factors are critical regulators of cell growth and differentiation in multiple lineages and have been linked to human cancers including acute myelogenous leukemia (RUNX1), as well as breast (RUNX2) and gastric cancers (RUNX3).
Pockwinse, Shirwin M., Rajgopal, Arun, Young, Daniel W., Mujeeb, Khwaja A., Nickerson, Jeffrey A., Javed, Amjad, Redick, Sambra D., Lian, Jane B., Van Wijnen, Andre J., Stein, Janet L., Stein, Gary S., Doxsey, Stephen J.   +11 more
openaire   +3 more sources

Biology of RUNX2 and Cleidocranial Dysplasia

Journal of Craniofacial Surgery, 2013
Three features of cleidocranial dysplasia that are not always appreciated are hypoplastic iliac wings, short stature, and brachydactyly. Because of the pelvic abnormality, pregnant women may require a cesarean delivery. Short stature and brachydactyly indicate more generalized skeletal abnormalities.
openaire   +2 more sources

Roles of Runx2 in Skeletal Development

2017
Runx2 is the most upstream transcription factor essential for osteoblast differentiation. It regulates the expression of Sp7, the protein of which is a crucial transcription factor for osteoblast differentiation, as well as that of bone matrix genes including Spp1, Ibsp, and Bglap2.
openaire   +2 more sources

RUNX2 analysis of Danish cleidocranial dysplasia families

Clinical Genetics, 2011
Cleidocranial dysplasia (CCD) is an autosomal dominant inherited disease caused by mutations in the Runt gene RUNX2. Screening of 19 Danish CCD families revealed 16 pathogenic mutations (84%) representing 8 missense mutations, 2 nonsense mutations, 4 frame-shift mutations and 2 large deletions in the RUNX2 locus.
Hansen, L, Riis, A K, Silahtaroglu, A, Hove, H, Lauridsen, E, Eiberg, H, Kreiborg, S   +6 more
openaire   +3 more sources

Hypoxia suppresses runx2 independent of modeled microgravity

Journal of Cellular Physiology, 2004
AbstractBone loss is a consequence of skeletal unloading as seen in bed rest and space flight. Unloading decreases oxygenation and osteoblast differentiation/function in bone. Previously we demonstrated that simulation of unloading in vitro, by culturing differentiating mouse osteoblasts in a horizontal rotating wall vessel (RWV), results in suppressed
Christopher, Ontiveros, Regina, Irwin, Robert W, Wiseman, Laura R, McCabe   +3 more
openaire   +2 more sources

Regulation of Osteoblast Differentiation by Runx2

2009
Runx2 protein is first detected in preosteoblasts, and the expression is upregulated in immature osteoblasts, but downregulated in mature osteoblasts. Runx2 is the first transcription factor required for determination of the osteoblast lineage, while Sp7 and canonical Wnt-signaling further direct the fate of mesenchymal cells to osteoblasts, blocking ...
openaire   +2 more sources