Results 241 to 250 of about 41,144 (263)

Runx2, an inducer of osteoblast and chondrocyte differentiation

Histochemistry and Cell Biology, 2018
Runx2 is a transcription factor that is essential for osteoblast differentiation and chondrocyte maturation. Ihh, expressed in prehypertrophic and hypertrophic chondrocytes, is required for the specification of Runx2+ osteoprogenitors in endochondral bone development.
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Prognostic Implication of Immunohistochemical Runx2 Expression in Osteosarcoma

Tumori Journal, 2009
Aims and background Osteosarcoma is the most common primary bone malignancy. Many genetic markers have proven prognostic value in osteosarcoma and studies are under way to determine their potential application as specific therapeutic targets.
Kyu Yeoun Won, Hye-Rim Park, Yong-Koo Park   +2 more
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RUNX2 Quadruplication

Journal of Craniofacial Surgery, 2013
The RUNX2 transcription factor regulates osteoblast differentiation. Its absence, as with cleidocranial dysplasia, results in deficient bone formation. However, its excess seems to follow a dose response of over ossification. RUNX2 duplications (3 copies) are exceedingly rare but have been reported to cause craniosynostosis.
Matthew R, Greives, Eric A, Odessey, Darrel J, Waggoner, Deana S, Shenaq, Swaroop, Aradhya, Allison, Mitchell, Emma, Whitcomb, Neil, Warshawsky, Tong-Chuan, He, Russell R, Reid   +9 more
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Regulation of bone development and maintenance by Runx2

Frontiers in Bioscience, 2008
Runx2 and Sp7/Osterix determine the osteoblast lineage from mesenchymal stem cells with canonical Wnt signaling. In the process of osteoblast differentiation, these factors and canonical Wnt signaling molecules inhibit mesenchymal cells from differentiating into chondrocytes and adipocytes.
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Genomic characterization of the RUNX2 gene of Fugu rubripes

Gene, 2002
A 105 kb Fugu rubripes genomic region containing the RUNX2 ortholog (frunx2) was sequenced and analysed. Spanning 32 kb, frunx2 is seven times smaller than its human orthologue (223 kb). By comparison of Fugu and human genomic environment a stretch of conserved synteny, comprising the neighbouring genes on both sides, was identified.
Eggers, Jan Henrik, Stock, Michael, Fliegauf, Manfred, Vonderstrass, Birgitta, Otto, Florian   +4 more
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RUNX2 as a Prognostic Factor in Human Cancers

Critical Reviews in Eukaryotic Gene Expression
The RUNX2 transcription factor was discovered as an essential transcriptional regulator for commitment to osteoblast lineage cells and bone formation. Expression of RUNX2 in other tissues, such as breast, prostate, and lung, has been linked to oncogenesis, cancer progression, and metastasis.
J, Toner, Johnathan A R, Gordon, H, Greenyer, Peter, Kaufman, Janet L, Stein, Gary S, Stein, Jane B, Lian   +6 more
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Runx2 interactions with the osteoblast genome

2015
Runx2 is a master transcription factor in osteoblasts, yet its mechanism is poorly understood. In particular, there is a paucity of information about its target genes and their regulation. To address this, we first used ChIP Display to discover novel genomic targets occupied by Runx2 in living MC3T3-E1 osteoblastic cells.
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Dose-Dependent Effects of Runx2 on Bone Development

Journal of Bone and Mineral Research, 2009
Zhousheng Xiao, Junming Luo, L Darryl Quarles   +2 more
exaly  

RUNX2

2018
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Transcriptional regulation by RUNX2

Reactome - a curated knowledgebase of biological pathways, 2017
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