Results 241 to 250 of about 69,808 (343)

The Big Five Functional Levels of Vascular Calcification. [PDF]

Biology (Basel)
Villa-Bellosta R.
europepmc   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

RUNX2 inhibitor CADD522 improves bone microarchitecture and lipid metabolism in post-menopausal bone loss. [PDF]

NPJ Drug Discov
Ersek A, Kim MS, Suelzu C, Piec I, Matsangos A, Nurmemmedov E, Bull EC, Bartlett T, Dunn R, Dick JR, Lapidus R, Copeman DM, Tang JCY, Crichton PG, Pontifex MG, Fraser WD, Horwood NJ, Passaniti A, Green D.   +18 more
europepmc   +1 more source

LncRNA TUG1 sponges miR-204-5p to promote osteoblast differentiation through upregulating Runx2 in aortic valve calcification

Cardiovascular Research, 2018
Cong Yu, Li-Fu Li, Fei Xie, Shichao Guo, Fa-Yuan Liu, Nian-Guo Dong, Yong-Jun Wang   +6 more
semanticscholar   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Neddylation of NFATc1 and Runx2 regulates osteoclast-osteoblast balance and represents a dual-action therapeutic target for postmenopausal osteoporosis. [PDF]

Exp Mol Med
Lee J, Lee MY, Kim HS, Park JW, Moon GH, Park JB, Kim HJ, Kim SJ, Chun YS.   +8 more
europepmc   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Next Generation Smart Implant Surfaces: Engineering Multifunctional Antimicrobial, Immunomodulatory and Regenerative Interfaces

Journal of Periodontal Research, EarlyView.
Natural‐inspired nano‐textured implant surfaces can be functionalised to modulate macrophage polarisation and local immune responses. This bioactive control promotes improved tissue integration and healing outcomes. ABSTRACT Dental implants rely on a stable and functional interface between the implant surface, surrounding tissues, and the oral ...
Roberto S. Pessoa, Lauren E. Steele, Mehvish Mumtaz, Denver P. Linklater, Neil M. O'Brien‐Simpson, Vladimir Baulin, Peter Kingshott, Roy Judge, Alastair J. Sloan, Elena P. Ivanova   +9 more
wiley   +1 more source

Effect of Combined Iron Oxide Magnetic Nanoparticles and Magnetic Field Exposure on Osteogenic Differentiation of Mesenchymal Stem Cells: A Systematic Review and Meta-Analysis. [PDF]

Bioengineering (Basel)
Solopov M, Ishchenko R, Turchin V, Bushe V, Kavelina A, Akopian G, Lebed E, Popandopulo A.   +7 more
europepmc   +1 more source

Phloridzin Mitigates Aging‐Associated Periodontitis by Restraining Inflammatory Cell Death

Journal of Periodontal Research, EarlyView.
Phloridzin attenuated oxidative stressinduced senescence, inflammatory responses, and osteogenic dysfunction in HPDLCs. In an aging‐associated experimental periodontitis model, phloridzin alleviated alveolar bone loss, suggesting its potential to maintain periodontal tissue integrity under aging‐related inflammatory conditions.
Da Eun Lee, Eun‐Nam Kim, Gil‐Saeng Jeong   +2 more
wiley   +1 more source