Results 231 to 240 of about 66,303 (295)

p75NTR Promotes Circadian‐Driven Mineralization During Tooth Development via CK2/PER2 Pathway

Cell Proliferation, Volume 59, Issue 5, May 2026.
The diagram illustrates how the circadian rhythm regulates the p75NTR‐CK2‐PER2 axis, driving rhythmic biomineralisation during tooth development. ABSTRACT Circadian rhythm is an essential biological process that synchronises physiological activities with environmental light/dark cycles.
Manzhu Zhao, Hongyan Yuan, Di Wang, Meng Li, Bo Xie, Xuqiang Zou, Mingjie Lu, Ye Qiu, Jinlin Song   +8 more
wiley   +1 more source

Meckel's cartilage midsegment: spatiotemporal dynamics and osteogenic role in mice. [PDF]

Cell Tissue Res
Sun Q, Li C, Yin L, Xiao C, Peng Y, Liu J, Zhang J.   +6 more
europepmc   +1 more source

Pathophysiology and Molecular Signalling in Osteoporosis: Linking Risk Factors to Bone Loss

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Osteoporosis is a prevalent skeletal disorder characterised by progressive reduction in bone mass, microarchitectural deterioration, and increased fracture susceptibility. In India, approximately one‐third of the elderly population is affected by bone‐related disorders, and the global burden of osteoporosis continues to rise.
Pramoda G., Kamini Shivhare, Piyush Kumar Gupta, Amirhossein Sahebkar, Prashant Kesharwani, Rahul Shukla   +5 more
wiley   +1 more source

BMP4 dose dictates lineage specification bias in human periodontal ligament stem cells. [PDF]

Front Bioeng Biotechnol
Li Y, Tang Q, Li L, Lin C, Guo M, Zhang Y, Yan F, Lin M.   +7 more
europepmc   +1 more source

The Role of Piezo 1 in the Study of Intervertebral Disc Degeneration: Phenotype, Mechanism and Treatment

Orthopaedic Surgery, Volume 18, Issue 5, Page 897-914, May 2026.
As the key mechanotransducer in IVDD, Piezo1 orchestrates region‐specific degeneration across NP (senescence/ECM dysregulation), AF (apoptosis), and CEP (inflammation). This review integrates mechanistic pathways and assesses multimodal therapeutic targeting (pharmacologic/genetic/nutritional) to restore disc homeostasis.
Guangye Li, Chaoqun Feng, Haoyun Huang, Junwen Deng, Fei Yang, Rigao Chen   +5 more
wiley   +1 more source

Precision RNA interference of Smad3 and Runx2 via dual targeting nanocarriers mitigates aortic valve disease. [PDF]

J Transl Med
Voicu G, Mocanu CA, Safciuc F, Anghelache M, Turtoi M, Deleanu M, Simionescu M, Manduteanu I, Calin M.   +8 more
europepmc   +1 more source

Genetically reprogrammed BMSCs with Lamin B1 depletion enhance bone regeneration for osteoporosis therapy. [PDF]

Front Bioeng Biotechnol
Fu X, Huo S, Cao C, Hsu H, Huang J, Lei Y, Li J, Liu P, Zeng J, Lin S, Liang C.   +10 more
europepmc   +1 more source

Identification and Screening of Lactate‐Related Genes as Molecular Markers for Early Diagnosis of Steroid‐Induced Osteonecrosis of the Femoral Head

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Identification and validation of lactate‐related genes biomarkers for steroid‐induced osteonecrosis of the femoral head through integrated bioinformatics analysis, machine learning, and experimental verification. ABSTRACT Steroid‐induced osteonecrosis of the femoral head (SONFH) is a major cause of disability among young and middle‐aged adults. However,
Zehua Wang, Shuhang Dong, Kaige Xu, Xinyu Tang, Sijia Guo, Yaping Jiang, Yingze Zhang, Tao Li   +7 more
wiley   +1 more source

Estrogen promotes the angiogenesis and osteogenesis of bone marrow stromal cells via regulating ESR1/RUNX2 axis. [PDF]

Food Nutr Res
Han Z, Wei C.
europepmc   +1 more source

m⁶A-mediated stabilization of Bhlhe22 suppresses osteogenesis in osteoporosis by activating the PI3K-AKT-GSK3β signaling axis. [PDF]

Stem Cell Res Ther
Ye Q, Tao Q, Long X, Lou F, Li J, Li X, Tan D, Xiao J.   +7 more
europepmc   +1 more source