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Control of Tooth Morphogenesis by Runx2
Critical Reviews™ in Eukaryotic Gene Expression, 2006Odontogenesis is a complex process in which the interplay of signaling cascades of the epithelium and mesenchyme is critical. Evidence for the involvement of Runx2--a well-known osteogenic master transcription factor--in odontogenesis, has been accumulating.
Hyun-Mo, Ryoo, Xiu-Ping, Wang
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Biology of RUNX2 and Cleidocranial Dysplasia
Journal of Craniofacial Surgery, 2013Three features of cleidocranial dysplasia that are not always appreciated are hypoplastic iliac wings, short stature, and brachydactyly. Because of the pelvic abnormality, pregnant women may require a cesarean delivery. Short stature and brachydactyly indicate more generalized skeletal abnormalities.
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Immunolocalization and Expression of Runx2 in Tertiary Dentinogenesis
Hybridoma, 2010Runx2 is a new transcription factor that takes part in odontoblast differentiation. This study is aimed at investigating the immunolocalization and expression of Runx2 in the process of dental pulp injury and repair using immunohistochemical technique. In normal dental pulp, positive staining can hardly be detected.
Jun, Wen +4 more
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Regulation of Runx2 by MicroRNAs in osteoblast differentiation
Life Sciences, 2019Bone is one of the most dynamic organs in the body that continuously undergoes remodeling through bone formation and resorption. A cascade of molecules and pathways results in the osteoblast differentiation that is attributed to osteogenesis, or bone formation. The process of osteogenesis is achieved through participation of the Wnt pathway, FGFs, BMPs/
Akshaya, Narayanan +3 more
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Transcriptional co-repressors of Runx2
Journal of Cellular Biochemistry, 2006Runx2 is an essential transcription factor for skeletal mineralization because it stimulates osteoblast differentiation of mesenchymal stem cells, promotes chondrocyte hypertrophy, and contributes to endothelial cell migration and vascular invasion of developing bones.
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RUNX2 Promotes Malignant Progression in Glioma
Neurochemical Research, 2018Glioblastoma (GBM) is the most aggressive and lethal form of brain tumor. However, therapeutic strategies against malignant gliomas have not been completely established. Runt-related transcription factor 2 (Runx2) is an essential gene for skeletal development but its regulatory role in the malignant progression of glioma remains unclear.
Daisuke, Yamada +5 more
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Advances in Runx2 regulation and its isoforms
Medical Hypotheses, 2007During the last 10 years, we have witnessed major progress in skeleton biology. Runx2 is an accepted transcription factor essential for osteoblast development from mesenchymal stem cells and maturation into osteocytes and organize crucial events during bone formation. Alternations in Runx2 expression levels are associated with skeletal diseases.
Ya-Lin, Li, Zhou-Sheng, Xiao
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Roles of Runx2 in Skeletal Development
2017Runx2 is the most upstream transcription factor essential for osteoblast differentiation. It regulates the expression of Sp7, the protein of which is a crucial transcription factor for osteoblast differentiation, as well as that of bone matrix genes including Spp1, Ibsp, and Bglap2.
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Regulation of Runx2 by Histone Deacetylases in Bone
Current Protein & Peptide Science, 2016Osteogenesis involves a cascade of processes wherein mesenchymal stem cells differentiate towards osteoblasts, strictly controlled by a number of regulatory factors. Runx2 protein is a key transcription factor which serves as a master regulator for osteogenesis by activating the promoters of various osteoblastic genes.
Mohanakrishnan, Vishal +3 more
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Regulation of Osteoblast Differentiation by Runx2
2009Runx2 protein is first detected in preosteoblasts, and the expression is upregulated in immature osteoblasts, but downregulated in mature osteoblasts. Runx2 is the first transcription factor required for determination of the osteoblast lineage, while Sp7 and canonical Wnt-signaling further direct the fate of mesenchymal cells to osteoblasts, blocking ...
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