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RUNX2 and Cancer

open access: yesInternational Journal of Molecular Sciences, 2023
Runt-related transcription factor 2 (RUNX2) is critical for the modulation of chondrocyte osteoblast differentiation and hypertrophy. Recently discovered RUNX2 somatic mutations, expressional signatures of RUNX2 in normal tissues and tumors, and the prognostic and clinical significance of RUNX2 in many types of cancer have attracted attention and led ...
Tsung-Chieh Lin, Lin Tsung-Chieh
exaly   +3 more sources
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The expression of Runx2 in the pathogenesis of periodontitis

Oral Diseases, 2023
Abstract Objective Runt‐related transcription factor 2 (Runx2) plays an important role in bone metabolism; however, the relationship between Runx2 and periodontitis remains unclear. We investigated Runx2 expression in the gingiva of patients to explore its role in periodontitis.
Miaomiao Wang   +6 more
openaire   +2 more sources

RUNX2 and Osteosarcoma

Anti-Cancer Agents in Medicinal Chemistry, 2015
Osteosarcoma (OS) is the most common pediatric bone cancer in children and young adults. Previous studies have suggested the importance of osteoblast activity in OS tumorigenesis and metastasis, as OS is characterized by abnormal bone formation, while osteoblast is the predominant cell type both in OS and in metastatic tumor tissues.
Na, Li   +9 more
openaire   +2 more sources

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