Results 301 to 310 of about 69,808 (343)

Transcriptional co-repressors of Runx2

Journal of Cellular Biochemistry, 2006
Runx2 is an essential transcription factor for skeletal mineralization because it stimulates osteoblast differentiation of mesenchymal stem cells, promotes chondrocyte hypertrophy, and contributes to endothelial cell migration and vascular invasion of developing bones.
openaire   +2 more sources

Regulation of transforming growth factor-β1-stimulation of Runx2 acetylation for matrix metalloproteinase 13 expression in osteoblastic cells

Biological chemistry, 2021
Transforming growth factor beta 1 (TGF-β1) functions as a coupling factor between bone development and resorption. Matrix metalloproteinase 13 (MMP13) is important in bone remodeling, and skeletal dysplasia is caused by a deficiency in MMP13 expre-ssion.
K. Gomathi, M. Rohini, N. Partridge, N. Selvamurugan   +3 more
semanticscholar   +1 more source

Biology of RUNX2 and Cleidocranial Dysplasia

Journal of Craniofacial Surgery, 2013
Three features of cleidocranial dysplasia that are not always appreciated are hypoplastic iliac wings, short stature, and brachydactyly. Because of the pelvic abnormality, pregnant women may require a cesarean delivery. Short stature and brachydactyly indicate more generalized skeletal abnormalities.
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Immunolocalization and Expression of Runx2 in Tertiary Dentinogenesis

Hybridoma, 2010
Runx2 is a new transcription factor that takes part in odontoblast differentiation. This study is aimed at investigating the immunolocalization and expression of Runx2 in the process of dental pulp injury and repair using immunohistochemical technique. In normal dental pulp, positive staining can hardly be detected.
Jun, Wen, Rui, Tao, Longxing, Ni, Qingyue, Duan, Qun, Lu   +4 more
openaire   +2 more sources

RUNX2 Promotes Malignant Progression in Glioma

Neurochemical Research, 2018
Glioblastoma (GBM) is the most aggressive and lethal form of brain tumor. However, therapeutic strategies against malignant gliomas have not been completely established. Runt-related transcription factor 2 (Runx2) is an essential gene for skeletal development but its regulatory role in the malignant progression of glioma remains unclear.
Daisuke, Yamada, Koichi, Fujikawa, Kenji, Kawabe, Takuya, Furuta, Mitsutoshi, Nakada, Takeshi, Takarada   +5 more
openaire   +2 more sources

Advances in Runx2 regulation and its isoforms

Medical Hypotheses, 2007
During the last 10 years, we have witnessed major progress in skeleton biology. Runx2 is an accepted transcription factor essential for osteoblast development from mesenchymal stem cells and maturation into osteocytes and organize crucial events during bone formation. Alternations in Runx2 expression levels are associated with skeletal diseases.
Ya-Lin, Li, Zhou-Sheng, Xiao
openaire   +2 more sources

Osteoclast-derived miR-23a-5p-containing exosomes inhibit osteogenic differentiation by regulating Runx2.

Cellular Signalling, 2019
BACKGROUND Some microRNAs (miRNAs) are involved in osteogenic differentiation. In recent years, increasing evidences have revealed that exosomes contain specific miRNAs.
Jun-Xiao Yang, Peng Xie, Yu-Sheng Li, Ting Wen, Xu-Cheng Yang   +4 more
semanticscholar   +1 more source

Regulation of Runx2 by Histone Deacetylases in Bone

Current Protein & Peptide Science, 2016
Osteogenesis involves a cascade of processes wherein mesenchymal stem cells differentiate towards osteoblasts, strictly controlled by a number of regulatory factors. Runx2 protein is a key transcription factor which serves as a master regulator for osteogenesis by activating the promoters of various osteoblastic genes.
Mohanakrishnan, Vishal, Ramachandran, Ajeetha, Rajendran, Keerthana, Nagarajan, Selvamurugan   +3 more
openaire   +2 more sources

Roles of Runx2 in Skeletal Development

2017
Runx2 is the most upstream transcription factor essential for osteoblast differentiation. It regulates the expression of Sp7, the protein of which is a crucial transcription factor for osteoblast differentiation, as well as that of bone matrix genes including Spp1, Ibsp, and Bglap2.
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IL-6 and sIL-6R induces STAT3-dependent differentiation of human VSMCs into osteoblast-like cells through JMJD2B-mediated histone demethylation of RUNX2.

Bone, 2019
Inflammation and vascular calcification are independent risk factors of cardiovascular events. Vascular smooth muscle cells (VSMCs) exhibit osteoblast-like characteristics in response to various stimuli such as oxidized cholesterol and inflammation ...
A. Kurozumi, K. Nakano, Kaoru Yamagata, Y. Okada, S. Nakayamada, Yoshiya Tanaka   +5 more
semanticscholar   +1 more source