Results 311 to 320 of about 69,808 (343)

Regulation of Osteoblast Differentiation by Runx2

2009
Runx2 protein is first detected in preosteoblasts, and the expression is upregulated in immature osteoblasts, but downregulated in mature osteoblasts. Runx2 is the first transcription factor required for determination of the osteoblast lineage, while Sp7 and canonical Wnt-signaling further direct the fate of mesenchymal cells to osteoblasts, blocking ...
openaire   +2 more sources

Prognostic Implication of Immunohistochemical Runx2 Expression in Osteosarcoma

Tumori Journal, 2009
Aims and background Osteosarcoma is the most common primary bone malignancy. Many genetic markers have proven prognostic value in osteosarcoma and studies are under way to determine their potential application as specific therapeutic targets.
Kyu Yeoun Won, Hye-Rim Park, Yong-Koo Park   +2 more
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RUNX2 Quadruplication

Journal of Craniofacial Surgery, 2013
The RUNX2 transcription factor regulates osteoblast differentiation. Its absence, as with cleidocranial dysplasia, results in deficient bone formation. However, its excess seems to follow a dose response of over ossification. RUNX2 duplications (3 copies) are exceedingly rare but have been reported to cause craniosynostosis.
Matthew R, Greives, Eric A, Odessey, Darrel J, Waggoner, Deana S, Shenaq, Swaroop, Aradhya, Allison, Mitchell, Emma, Whitcomb, Neil, Warshawsky, Tong-Chuan, He, Russell R, Reid   +9 more
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Regulation of bone development and maintenance by Runx2

Frontiers in Bioscience, 2008
Runx2 and Sp7/Osterix determine the osteoblast lineage from mesenchymal stem cells with canonical Wnt signaling. In the process of osteoblast differentiation, these factors and canonical Wnt signaling molecules inhibit mesenchymal cells from differentiating into chondrocytes and adipocytes.
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RUNX2 as a Prognostic Factor in Human Cancers

Critical Reviews in Eukaryotic Gene Expression
The RUNX2 transcription factor was discovered as an essential transcriptional regulator for commitment to osteoblast lineage cells and bone formation. Expression of RUNX2 in other tissues, such as breast, prostate, and lung, has been linked to oncogenesis, cancer progression, and metastasis.
J, Toner, Johnathan A R, Gordon, H, Greenyer, Peter, Kaufman, Janet L, Stein, Gary S, Stein, Jane B, Lian   +6 more
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Runx2 interactions with the osteoblast genome

2015
Runx2 is a master transcription factor in osteoblasts, yet its mechanism is poorly understood. In particular, there is a paucity of information about its target genes and their regulation. To address this, we first used ChIP Display to discover novel genomic targets occupied by Runx2 in living MC3T3-E1 osteoblastic cells.
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Bone development by Hedgehog and Wnt signaling, Runx2, and Sp7

Journal of Bone and Mineral Metabolism
T. Komori
semanticscholar   +1 more source

RUNX2 and Cleidocranial Dysplasia

2016
Lindsay C. Burrage, Yangjin Bae, Brendan H. Lee, Dobrawa Napierala   +3 more
openaire   +1 more source

Investigating the role of Runx2 in haematopoiesis

Self-renewing multipotent haematopoietic stem cells (HSCs) are a rare but vital cell population supporting life-long homeostasis of the entire blood and immune system. Due to the paucity of HSCs and limitations in ex vivo HSC expansion, it has been difficult to comprehensively study the genetic regulators of the balancing of HSC self-renewal and ...
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Dose-Dependent Effects of Runx2 on Bone Development†

Journal of Bone and Mineral Research, 2009
Zhousheng Xiao, Darryl Quarles, Nan He
exaly