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Regulation of Runx2 by MicroRNAs in osteoblast differentiation.
Life Sciences, 2019Bone is one of the most dynamic organs in the body that continuously undergoes remodeling through bone formation and resorption. A cascade of molecules and pathways results in the osteoblast differentiation that is attributed to osteogenesis, or bone ...
A. Narayanan +3 more
semanticscholar +3 more sources
The expression of Runx2 in the pathogenesis of periodontitis
Oral Diseases, 2023Abstract Objective Runt‐related transcription factor 2 (Runx2) plays an important role in bone metabolism; however, the relationship between Runx2 and periodontitis remains unclear. We investigated Runx2 expression in the gingiva of patients to explore its role in periodontitis.
Miaomiao Wang +6 more
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Runx2, an inducer of osteoblast and chondrocyte differentiation
Histochemistry and Cell Biology, 2018Runx2 is a transcription factor that is essential for osteoblast differentiation and chondrocyte maturation. Ihh, expressed in prehypertrophic and hypertrophic chondrocytes, is required for the specification of Runx2+ osteoprogenitors in endochondral bone development.
T. Komori
semanticscholar +3 more sources
RUNX2 Regulates Osteoblast Differentiation via the BMP4 Signaling Pathway
Journal of dentistry research, 2022RUNX2 is a master osteogenic transcription factor, and mutations in RUNX2 cause the inherited skeletal disorder cleidocranial dysplasia (CCD). Studies have revealed that RUNX2 is not only a downstream target of the bone morphogenetic protein (BMP ...
D.-D. Liu +5 more
semanticscholar +1 more source
Anti-Cancer Agents in Medicinal Chemistry, 2015
Osteosarcoma (OS) is the most common pediatric bone cancer in children and young adults. Previous studies have suggested the importance of osteoblast activity in OS tumorigenesis and metastasis, as OS is characterized by abnormal bone formation, while osteoblast is the predominant cell type both in OS and in metastatic tumor tissues.
Na, Li +9 more
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Osteosarcoma (OS) is the most common pediatric bone cancer in children and young adults. Previous studies have suggested the importance of osteoblast activity in OS tumorigenesis and metastasis, as OS is characterized by abnormal bone formation, while osteoblast is the predominant cell type both in OS and in metastatic tumor tissues.
Na, Li +9 more
openaire +2 more sources
Molecular Mechanism of Runx2-Dependent Bone Development
Molecules and Cells, 2020Runx2 is an essential transcription factor for skeletal development. It is expressed in multipotent mesenchymal cells, osteoblast-lineage cells, and chondrocytes. Runx2 plays a major role in chondrocyte maturation, and Runx3 is partly involved.
T. Komori
semanticscholar +1 more source
Regulation of Runx2 by post-translational modifications in osteoblast differentiation.
Life Science, 2020Osteogenesis is the process of new bone formation where transcription factors play an important role in controlling cell proliferation and differentiation.
K. Gomathi +4 more
semanticscholar +1 more source
Control of Tooth Morphogenesis by Runx2
Critical Reviews™ in Eukaryotic Gene Expression, 2006Odontogenesis is a complex process in which the interplay of signaling cascades of the epithelium and mesenchyme is critical. Evidence for the involvement of Runx2--a well-known osteogenic master transcription factor--in odontogenesis, has been accumulating.
Hyun-Mo, Ryoo, Xiu-Ping, Wang
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