Results 51 to 60 of about 1,087,057 (333)
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Geodetic Observations of Weak Determinism in Rupture Evolution of Large Earthquakes. [PDF]
, 2018 The moment evolution of large earthquakes is a subject of fundamental interest to both basic and applied seismology. Specifically, an open problem is when in the rupture process a large earthquake exhibits features dissimilar from those of a lesser ...
Allen, RM +3 more
core
Investigating membrane breakdown of neuronal cells exposed to nonuniform electric fields by finite-element modeling and experiments [PDF]
, 2002 High electric field strengths may induce high cell membrane potentials. At a certain breakdown level the membrane potential becomes constant due to the transition from an insulating state into a high conductivity and high permeability state.
Heida, Tjitske +3 more
core +3 more sources
Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
Molecular Oncology, EarlyView.This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu +15 more
wiley +1 more source
Reconstruction After Distal Biceps Tendon Rupture
Journal of Orthopaedics, Trauma and Rehabilitation, 2012 Distal biceps ruptures are relatively uncommon, but should be diagnosed and treated promptly to have good outcome. In this review article we will briefly summarize the anatomy and mechanism of injury, but the focus of this article will be on diagnosis ...
Matthias Vanhees, Roger P. van Riet
doaj +1 more source
Real-Time Estimation of Fault Rupture Extent Using Envelopes of Acceleration [PDF]
, 2008 We present a new strategy to estimate the geometry of a rupture on a finite fault in real time for earthquake early warning. We extend the work of Cua and Heaton who developed the virtual seismologist (VS) method (Cua, 2005), which is a Bayesian approach
Heaton, Thomas, Yamada, Masumi
core +1 more source
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source
Uplift and subsidence associated with the great Aceh-Andaman earthquake of 2004 [PDF]
, 2006 Rupture of the Sunda megathrust on 26 December 2004 produced broad regions of uplift and subsidence. We define the pivot line separating these regions as a first step in defining the lateral extent and the downdip limit of rupture during that great M_w ≈
Abrams, Michael +6 more
core +1 more source
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source