PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Finite Element Analysis of Air Gun Impact on Post-Keratoplasty Eye
Clinical Ophthalmology, 2020 Kanno Okamura, Asami Shimokawa, Rie Takahashi, Yusuke Saeki, Hiroaki Ozaki, Eiichi Uchio Department of Ophthalmology, Fukuoka University School of Medicine, Fukuoka, JapanCorrespondence: Eiichi UchioDepartment of Ophthalmology, Fukuoka University School ...
Okamura K +5 more
doaj
The 2007 Azores earthquakes: A case of triggering? [PDF]
, 2009 On 5 April (Mw=6.3) and 7 April 2007 (Mw=6.1 ) two earthquakes occur at the Formigas Islets (Azores Islands), both with same epicenter and felt (I=V/VI MSK) in S. Miguel Island.
Bezzghoud, M +3 more
core
Stability of heterogeneous parallel-bond adhesion clusters under static load
, 2020 Adhesion interactions mediated by multiple bond types are relevant for many biological and soft matter systems, including the adhesion of biological cells and functionalized colloidal particles to various substrates.
Dasanna, Anil K. +2 more
core +1 more source
Properties of Dynamic Earthquake Ruptures With Heterogeneous Stress Drop [PDF]
, 2006 Earthquake rupture is a notoriously complex process, at all observable scales. We introduce a simplified semi-dynamic crack model to investigate the connection between the statistical properties of stress and those of macroscopic source parameters ...
Ampuero, J.-P. +2 more
core +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Source Mechanism and Rupture Directivity of the 18 May 2009 M_W 4.6 Inglewood, California, Earthquake [PDF]
, 2010 On 18 May 2009, an M_w 4.6 earthquake occurred beneath Inglewood, California, and was widely felt. Though source mechanism and its location suggest that the Newport–Inglewood fault (NIF) may be involved in generating the earthquake, rupture directivity ...
Chen, Yong +7 more
core
Noninvasive imaging of focal atherosclerotic lesions using fluorescence molecular tomography [PDF]
, 2014 Insights into the etiology of stroke and myocardial infarction suggest that rupture of unstable atherosclerotic plaque is the precipitating event. Clinicians lack tools to detect lesion instability early enough to intervene, and are often left to manage ...
Abendschein, Dana R. +9 more
core +2 more sources
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source