Results 81 to 90 of about 1,516,854 (381)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

A case of catastrophic epistaxis from the internal carotid artery due to multiple surgeries and irradiations for pituitary tumor: Rescued utilizing high‐flow bypass and simultaneous skull base reconstruction

Clinical Case Reports, 2021
Revascularization for internal carotid artery rupture should be considered immediately under the situation where endovascular treatment is not indicated. Revascularization can prevent the risk of hemorrhage during skull base reconstruction.
Kosuke Takabayashi, Seiji Takebayashi, Juro Sakurai, Shuho Gotoh, Katsumi Takizawa   +4 more
doaj   +1 more source

Ruptured Suprasellar Dermoid Cyst Treated With Lumbar Drain to Prevent Postoperative Hydrocephalus: Case Report and Focused Review of Literature

Frontiers in Surgery, 2021
Background: Ruptured intracranial dermoid cysts are extremely rare. Standard treatment consists of endonasal decompression or craniotomy with evacuation and copious irrigation of subarachnoid spaces to remove any disseminated cystic contents ...
Sarah E. Blitz, Joshua D. Bernstock, Joshua D. Bernstock, Adam A. Dmytriw, Adam A. Dmytriw, Daniel Francis Ditoro, Daniel Francis Ditoro, Ari D. Kappel, Ari D. Kappel, William B. Gormley, William B. Gormley, Pierpaolo Peruzzi, Pierpaolo Peruzzi   +12 more
doaj   +1 more source

Turbulent breakage of ductile aggregates

, 2015
In this paper we study breakage rate statistics of small colloidal aggregates in non-homogeneous anisotropic turbulence. We use pseudo-spectral direct numerical simulation of turbulent channel flow and Lagrangian tracking to follow the motion of the ...
Marchioli, Cristian, Soldati, Alfredo
core   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Statins Reduce Abdominal Aortic Aneurysm Growth, Rupture, and Perioperative Mortality: A Systematic Review and Meta‐Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background There are no recognized pharmacological treatments for abdominal aortic aneurysms (AAA), although statins are suggested to be beneficial. We sought to summarize the literature regarding the effects of statins on human AAA growth, rupture, and ...
Konrad Salata, Muzammil Syed, Mohamad A. Hussain, Charles de Mestral, Elisa Greco, Muhammad Mamdani, Jack V. Tu, Thomas L. Forbes, Deepak L. Bhatt, Subodh Verma, Mohammed Al‐Omran   +10 more
doaj   +1 more source

Geodetic Observations of Weak Determinism in Rupture Evolution of Large Earthquakes. [PDF]

, 2018
The moment evolution of large earthquakes is a subject of fundamental interest to both basic and applied seismology. Specifically, an open problem is when in the rupture process a large earthquake exhibits features dissimilar from those of a lesser ...
Allen, RM, Bock, Y, Goldberg, DE, Melgar, D   +3 more
core  

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

The 2007 Azores earthquakes: A case of triggering? [PDF]

, 2009
On 5 April (Mw=6.3) and 7 April 2007 (Mw=6.1 ) two earthquakes occur at the Formigas Islets (Azores Islands), both with same epicenter and felt (I=V/VI MSK) in S. Miguel Island.
Bezzghoud, M, Borges, JF, Buforn, E, Caldeira, B   +3 more
core