Results 1 to 10 of about 2,517 (166)

An adenovirus-vectored RVF vaccine confers complete protection against lethal RVFV challenge in A129 mice

Frontiers in Microbiology, 2023
Instruction: Rift valley fever virus (RVFV) is a mosquito-transmitted bunyavirus that causes severe disease in animals and humans. Nevertheless, there are no vaccines applied to prevent RVFV infection for human at present.
Changming Yu, Jianmin Li, Ting Bian
exaly   +5 more sources

RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosis

PLoS Pathogens
Infection of Rift Valley fever virus (RVFV), a highly pathogenic mosquito-borne zoonotic virus, triggers severe inflammatory pathogenesis but the underlying mechanism of inflammation activation is currently unclear.
Ke Peng, Zhenqiong Guan
exaly   +4 more sources

Urban risk factors for human Rift Valley fever virus exposure in Kenya

PLOS Global Public Health, 2022
The Rift Valley fever virus (RVFV) is a zoonotic arbovirus that can also transmit directly to humans from livestock. Previous studies have shown consumption of sick animal products are risk factors for RVFV infection, but it is difficult to disentangle ...
Keli Nicole Gerken, Francis Maluki Mutuku, Bryson Alberto Ndenga, Gladys Adhiambo Agola, Eleonora Migliore, Eduardo Palacios Fabre, Said Malumbo, Karren Nyumbile Shaita, Izabela Mauricio Rezende, A. Desiree LaBeaud   +9 more
doaj   +2 more sources

Epidemiology and serological detection of Rift Valley Fever disease in farm animals in southern Egypt

Onderstepoort Journal of Veterinary Research, 2021
In this study, the serological surveillance of Rift Valley Fever virus (RVFV) in southern Egypt was carried out for 460 serum samples collected from domestic animals (unvaccinated), including cattle, sheep, goat, camel and donkey reared in three ...
Hassan Y.A.H. Mahmoud, Alsagher O. Ali
doaj   +1 more source

Bacterium-Like Particles Displaying the Rift Valley Fever Virus Gn Head Protein Induces Efficacious Immune Responses in Immunized Mice

Frontiers in Microbiology, 2022
Rift Valley fever virus (RVFV), a mosquito-borne zoonotic phlebovirus, causes serious disease in humans and ruminants. According to the World Health Organization, Rift Valley fever is classified as a priority disease, and as such, vaccine development is ...
Shengnan Zhang, Feihu Yan, Dongping Liu, Entao Li, Na Feng, Shengnan Xu, Hualei Wang, Yuwei Gao, Songtao Yang, Yongkun Zhao, Xianzhu Xia   +10 more
doaj   +1 more source

A highly potent human neutralizing antibody prevents vertical transmission of Rift Valley fever virus in a rat model

Nature Communications, 2023
Rift Valley fever virus (RVFV) is an emerging mosquito-transmitted virus that circulates in livestock and humans in Africa and the Middle East. Outbreaks lead to high rates of miscarriages in domesticated livestock.
Cynthia M. McMillen, Nathaniel S. Chapman, Ryan M. Hoehl, Lauren B. Skvarca, Madeline M. Schwarz, Laura S. Handal, James E. Crowe, Amy L. Hartman   +7 more
doaj   +1 more source

Postepidemic analysis of Rift Valley fever virus transmission in northeastern kenya: a village cohort study. [PDF]

PLoS Neglected Tropical Diseases, 2011
In endemic areas, Rift Valley fever virus (RVFV) is a significant threat to both human and animal health. Goals of this study were to measure human anti-RVFV seroprevalence in a high-risk area following the 2006-2007 Kenyan Rift Valley Fever (RVF ...
A Desirée LaBeaud, Samuel Muiruri, Laura J Sutherland, Saidi Dahir, Ginny Gildengorin, John Morrill, Eric M Muchiri, Clarence J Peters, Charles H King   +8 more
doaj   +1 more source

In-vitro and in-vivo study of the interference between Rift Valley fever virus (clone 13) and Sheeppox/Limpy Skin disease viruses

Scientific Reports, 2021
Viral interference is a common occurrence that has been reported in cell culture in many cases. In the present study, viral interference between two capripox viruses (sheeppox SPPV and lumpy skin disease virus LSDV in cattle) with Rift Valley fever virus
N. Safini, Z. Bamouh, J. Hamdi, M. Jazouli, K. O. Tadlaoui, M. El Harrak   +5 more
doaj   +1 more source

Rift Valley Fever Virus Propagates in Human Villous Trophoblast Cell Lines and Induces Cytokine mRNA Responses Known to Provoke Miscarriage

Viruses, 2021
The mosquito-borne Rift Valley fever (RVF) is a prioritised disease that has been listed by the World Health Organization for urgent research and development of counteraction.
Yong-Dae Gwon, Seyed Alireza Nematollahi Mahani, Ivan Nagaev, Lucia Mincheva-Nilsson, Magnus Evander   +4 more
doaj   +1 more source

Single-dose of a replication-competent adenovirus-vectored vaccine provides sterilizing protection against Rift Valley fever virus challenge

Frontiers in Immunology, 2022
Rift Valley fever virus (RVFV) is one of the most important virulent pathogens causing severe disease in animals and humans. However, there is currently no approved vaccine to prevent RVFV infection in humans. The use of human adenovirus serotype 4 (Ad4)
Ting Bian, Busen Wang, Guangcheng Fu, Meng Hao, Yi Chen, Ting Fang, Shuling Liu, Changming Yu, Jianmin Li, Jianmin Li, Wei Chen   +10 more
doaj   +1 more source