Results 101 to 110 of about 27,021 (267)

Molecular basis for inner kinetochore configuration through RWD domain–peptide interactions

The EMBO Journal, 2017
Kinetochores are dynamic cellular structures that connect chromosomes to microtubules. They form from multi-protein assemblies that are evolutionarily conserved between yeasts and humans. One of these assemblies-COMA-consists of subunits Ame1CENP-U, Ctf19CENP-P, Mcm21CENP-O and Okp1CENP-Q A description of COMA molecular organization has so far been ...
Florian Schmitzberger, Magdalena M Richter, Yuliya Gordiyenko, Carol V Robinson, Michał Dadlez, Stefan Westermann   +5 more
openaire   +4 more sources

An Implanted Tooth That Can Feel

Advanced Science, EarlyView.
To endow the implanted tooth with masticatory perception, herein we demonstrate that a 3D‐printed piezoelectric‐core/robust‐sheath implanted tooth can rebuild the sensing feedback, serving as “mechanoreceptors” in converting the mechanical chewing force to electrical signals, and up to brain through surrounding alveolar nerve system.
Yaru Cao, Zhenhua Wu, Jiwei Sun, Ke Song, Jiayi Li, Yujin Li, Wenqi Chen, Hanyu Li, Shue Li, Cheng Yang, Silin Liu, Yunyun Han, Bin Su, Yumei Ding   +13 more
wiley   +1 more source

Impact of Delaying Disease Recurrence on Economic Burden in Patients with HER2+ Early-Stage Breast Cancer (eBC)

ClinicoEconomics and Outcomes Research
Nicole Princic,1 Eleanor Faherty,2 Meghan Moynihan,1 Caroline Henriques,2 Sandhya Mehta1 1Data Research & Analytics, Real World Data, MarketScan by Merative, Ann Arbor, MI, USA; 2HEOR & RWE, US Medical Affairs, Daiichi Sankyo, Inc., Basking Ridge,
Princic N, Faherty E, Moynihan M, Henriques C, Mehta S   +4 more
doaj  

The SW Sex-type star 2MASS J01074282+4845188: an unusual bright accretion disk with non-steady emission and a hot white dwarf

, 2013
We present new photometric and spectral observations of the newly discovered nova-like eclipsing star 2MASS J01074282+4845188. To obtain a light curve solution we used model of a nova-like star whose emission sources are a white dwarf surrounded by an ...
Dimitrov, D., Khruzina, T., Kjurkchieva, D.   +2 more
core   +1 more source

H2S‐Releasing Aspirin Nanoparticles Alleviate Endometriosis and Associated Anxiety

Advanced Science, EarlyView.
Albumin nanoparticles loaded with an H2S‐releasing aspirin derivative (ACS14) hitchhiking neutrophils after intraperitoneal injection and preferentially accumulate in endometriosis lesions in mice. The treatment suppresses lesion growth by regulating PI3K/Akt and reduces inflammation by inhibiting NF‐κB.
Mengni Zhou, Renbin Dou, Rong Wu, Yunyu Xu, Ying Wang, Peng Wang, Jinfu Li, Pengcheng Lu, Yu Mao, Jieying Qian, Yunjiao Zhang, Jiqian Zhang, Shasha Zhu   +12 more
wiley   +1 more source

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

Advanced Science, EarlyView.
TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen   +16 more
wiley   +1 more source

Real-world data: a comprehensive literature review on the barriers, challenges, and opportunities associated with their inclusion in the health technology assessment process

Journal of Pharmacy & Pharmaceutical Sciences
Objective: This review aimed to assess the current use and acceptance of real-world data (RWD) and real-world evidence (RWE) in health technology assessment (HTA) process.
Konstantinos Zisis, Konstantinos Zisis, Elpida Pavi, Mary Geitona, Kostas Athanasakis   +4 more
doaj   +1 more source

Synergistic Hydrogen‐Bonding and Covalent Crosslinking in Polybenzimidazole Membranes for Wide‐Temperature Anhydrous Fuel Cells

Advanced Science, EarlyView.
A dual‐network architecture combining a thermally reinforced hydrogen‐bonding matrix with an amine‐anhydride covalent framework was constructed in Tröger's Base (TB)‐functionalized polybenzimidazoles. This design yielded the TBAm‐PBI‐TB membrane with high acid uptake (469.5%), anhydrous conductivity (264.7 mS cm−1), and robust stability.
Junming Dai, Jianming Zhong, Jinpeng Luo, Yuxing Song, Fan Hu, Young Moo Lee, Yongbing Zhuang   +6 more
wiley   +1 more source

Periodontitis and atherosclerotic cardiovascular disease: A critical appraisal

Periodontology 2000, EarlyView., 2023
Abstract In spite of intensive research efforts driving spectacular advances in terms of prevention and treatments, cardiovascular diseases (CVDs) remain a leading health burden, accounting for 32% of all deaths (World Health Organization. “Cardiovascular Diseases (CVDs).” WHO, February 1, 2017, https://www.who.int/news‐room/fact‐sheets/detail ...
Maria Clotilde Carra, Hélène Rangé, Giuseppina Caligiuri, Philippe Bouchard   +3 more
wiley   +1 more source

A national evaluation analysis and expert interview study of real-world data sources for research and healthcare decision-making

Scientific Reports
Real-world data (RWD) can provide intel (real-world evidence, RWE) for research and development, as well as policy and regulatory decision-making along the full spectrum of health care.
Veronika Mikl, Dejan Baltic, Thomas Czypionka, Alexander Degelsegger-Márquez, Nikolaus Forgó, Ghazaleh Gouya-Lechner, Arnold Herzog, Peter Klimek, David Benjamin Lumenta, Bernhard Mraz, Herwig Ostermann, Robert Scharinger, Tanja Stamm, Michael Strassnig, Markus Zeitlinger, Johannes Pleiner-Duxneuner   +15 more
doaj   +1 more source