Results 101 to 110 of about 14,665 (304)

Impact of Delaying Disease Recurrence on Economic Burden in Patients with HER2+ Early-Stage Breast Cancer (eBC)

ClinicoEconomics and Outcomes Research
Nicole Princic,1 Eleanor Faherty,2 Meghan Moynihan,1 Caroline Henriques,2 Sandhya Mehta1 1Data Research & Analytics, Real World Data, MarketScan by Merative, Ann Arbor, MI, USA; 2HEOR & RWE, US Medical Affairs, Daiichi Sankyo, Inc., Basking Ridge,
Princic N, Faherty E, Moynihan M, Henriques C, Mehta S   +4 more
doaj  

A comparative study of clinical trial and real-world data in patients with diabetic kidney disease

Scientific Reports
A growing body of research is focusing on real-world data (RWD) to supplement or replace randomized controlled trials (RCTs). However, due to the disparities in data generation mechanisms, differences are likely and necessitate scrutiny to validate the ...
Samu Kurki, Viivi Halla-aho, Manuel Haussmann, Harri Lähdesmäki, Jussi V. Leinonen, Miika Koskinen   +5 more
doaj   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

A systematic review of real-world evidence (RWE) supportive of new drug and biologic license application approvals in rare diseases

Orphanet Journal of Rare Diseases
Background Real-world evidence (RWE) generated using real-world data (RWD) presents the potential to contextualize and/or supplement traditional clinical trials for regulatory approval of rare diseases (RDs).
Shailja Vaghela, Kaniz Afroz Tanni, Geetanjoli Banerjee, Vanja Sikirica   +3 more
doaj   +1 more source

Recommendations for developing drug use definitions with an emphasis on real-world data sources

Реальная клиническая практика: данные и доказательства
There is currently no established framework for conceptualizing or implementing drug use. These recommendations provide a framework that outlines considerations to be considered when developing definitions of drug use in real-world clinical practice. The
A. S. Motrinchuk, M. V. Pchelintsev
doaj   +1 more source

Building learning health systems on Real World Data

International Journal of Integrated Care, 2019
Background: Health systems are witnessing two transitions that rarely look at each other: a) the epidemiological shift that implies health systems to adapt from the delivery of acute fragmented services to the provision of coordinated chronic care; and b)
Enrique Bernal-Delgado, Anibal García-Sempere, Ibai Tamayo-Rodríguez, Francisco Estupiñán-Romero, Felipe Aizupuru-Barandiaran, Ana Toledo-Chavarri   +5 more
doaj   +1 more source

MES-CoBrad D8.3 Participant recruitment, Pre-existing RWD access, Prospective RWD acquisition and secure storage -v1

, 2022
The Multidisciplinary Expert System for the Assessment & Management of Complex Brain Disorders (MES-CoBraD) project integrates a group of professionals with inter-expertise and where a wide number of different fields of research interact. Four centres from the collaborative effort, have agreed to incorporate participant data, ranging from clinical ...
openaire   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Governance of collection, use and storage of RWD in the view of data protection concerns [PDF]

, 2019
Collection, storage and sharing RWD raise concerns regarding the privacy, data protection and governance of access. To date, the concerns related to consent and adequate safeguards for data protection in conventional research and health care settings are
Shabani, Mahsa
core   +2 more sources

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source