Results 61 to 70 of about 27,021 (267)

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Transforming breast cancer management with real-world data and artificial intelligence

ESMO Real World Data and Digital Oncology
Background: Real-world data (RWD) provide essential insights into the effectiveness and safety of breast cancer treatments, particularly in diverse patient populations, where traditional clinical trials may have limitations.
P. Heudel, B. Mery, H. Crochet, T. Bachelot, O. Tredan   +4 more
doaj   +1 more source

Comprehensive Subgrade Deflection Acceptance Criteria - Pilot Implementation Report [PDF]

, 2002
This report has presents the findings of implementations of pilot specifications for subgrade acceptance based on measured deflections. The reconfigured rolling wheel deflectomter (RWD), portable truck-mounted deflection measurement systems, and dynamic ...
Crovetti, James, Schabelski, Jay
core   +1 more source

Tidal disruption and ignition of white dwarfs by moderately massive black holes

, 2008
We present a numerical investigation of the tidal disruption of white dwarfs by moderately massive black holes, with particular reference to the centers of dwarf galaxies and globular clusters.
Baumgardt, Benz, Carter, Dearborn, E. Ramirez-Ruiz, Gaensicke, Gebhardt, Gebhardt, Gerssen, Gerssen, Ghez, Greene, Hix, Khokhlov, Kobayashi, Luminet, Mathur, Moehler, Paczyński, Phinney, Ramirez-Ruiz, Rosswog, Rosswog, Rosswog, Rosswog, S. Rosswog, Salaris, Straniero, Timmes, W. R. Hix, Wilson   +30 more
core   +1 more source

Classical simulation versus universality in measurement based quantum computation [PDF]

, 2006
We investigate for which resource states an efficient classical simulation of measurement based quantum computation is possible. We show that the Schmidt--rank width, a measure recently introduced to assess universality of resource states, plays a ...
Briegel, H. J., Dür, W., Nest, M. Van den, Vidal, G.   +3 more
core   +2 more sources

Anti‐Apoptotic and Neurite‐Protective Nanomedicine Augments Embryonic Stem Cells‐Derived Retinal Ganglion Cell Transplantation in Glaucoma Recovery

Advanced Science, EarlyView.
Lithium‐epigallocatechin gallate nanoparticles (Li‐EGCG NPs) are co‐transplanted with embryonic stem cell‐derived retinal ganglion cells (ESC‐RGCs) to enhance cell survival and therapeutic efficacy in an acute pathological glaucomatous injury model. This synergistic approach protects RGC cells, preserves retinal structure and improves visual function ...
Moxin Chen, Xiaoyan Jiang, Yuanhui Wang, Zhaobin Luo, Yu Zhang, Siwei Liu, Rui Huang, Dandan Zhang, Zhimin Tang, Yahan Ju, Shaohui Pan, Ni Ni, Wei Feng, Yu Chen, Ping Gu   +14 more
wiley   +1 more source

Compton Scattering of Fe K alpha Lines in Magnetic Cataclysmic Variables

, 2007
Compton scattering of X-rays in the bulk flow of the accretion column in magnetic cataclysmic variables (mCVs) can significantly shift photon energies. We present Monte Carlo simulations based on a nonlinear algorithm demonstrating the effects of Compton
A. L. McNamara, Costa, Cropper, Cullen, D. K. Galloway, Frank, Hellier, Hellier, Hellier, J. G. Cullen, K. Wu, King, Kuncic, Lamb, Matt, Morales Rueda, Nauenberg, Pozdnyakov, Stern, Sunyaev, Vrielmann, Warner, Wu, Wu, Wu, Wu, Z. Kuncic   +26 more
core   +1 more source

"Dark Matter" in Accretion Disks [PDF]

, 2008
Using Spitzer Space Telescope photometric observations of the eclipsing, interacting binary WZ Sge, we have discovered that the accretion disk is far more complex than previously believed.
Brinkworth, C., Hoard, D. W., Howell, Steve B., Kafka, S., Rector, T. A., Walentosky, M. J., Walter, Frederick M.   +6 more
core   +3 more sources

Reply to Function and Structure of the RWD Domain

Journal of Biological Chemistry, 2015
This is a response to a letter by Paez-Pereda and Arzt (1) The Letter to the Editor by Paez-Pereda and Arzt (1) suggested that our recent findings (2) are consistent with their previous findings (3). We disagree. The cited publication (3) proposed that RSUME interacts with both Ubc9 and SUMO-1 simultaneously, although the binding affinity was not
Aileen, Alontaga, Yuan, Chen
openaire   +2 more sources

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source