Results 61 to 70 of about 14,665 (304)

Opportunities and Challenges for AI-Based Analysis of RWD in Pharmaceutical R&D: A Practical Perspective [PDF]

, 2023
Real world data (RWD) has become an important tool in pharmaceutical research and development. Generated every time patients interact with the healthcare system when diagnoses are developed and medical interventions are selected, RWD are massive and in ...
Burghaus, Rolf, Lippert, Jörg, Diedrich, Christian, Behr, Merle   +3 more
core   +1 more source

Improving Web user Experience by Adapting RWD

International Journal of Engineering and Advanced Technology, 2020
Responsive Web Design (RWD) is a design which focuses on responsively fitting in whatever device the website is accessed from. It involves writing code for all possible screen sizes and bundling them together. Hence when the website is accessed, the whole bundle alongside the code for all screen sizes are downloaded to the user’s device and acts ...
K. Naveen Bharathi, M. Kavitha Margret
openaire   +2 more sources

Intravital Multimodal Imaging of Human Cortical Organoid Transplantation in a Mouse Model of Chronic Stroke

Advanced Science, EarlyView.
A multimodal intravital imaging platform enables longitudinal tracking of human cortical organoids transplanted into chronic stroke lesions. By combining surgical microscopy, MRI, bioluminescence imaging, and two‐photon fluorescence microscopy, the platform captures graft placement, viability dynamics, and cellular‐scale morphology in vivo, offering a ...
Jinghui Wang, Guanda Qiao, Honglin Tan, Colleen Russel, Baixuan Yang, Mengyang Jacky Li, Kexin Wang, Jiadi Xu, Chengyan Chu, Miroslaw Janowski, Tian‐Ming Fu, Piotr Walczak, Yajie Liang   +12 more
wiley   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Role of Real-World Data in Assessing Cardiac Toxicity After Lung Cancer Radiotherapy

Frontiers in Oncology, 2022
Radiation-induced heart disease (RIHD) is a recent concern in patients with lung cancer after being treated with radiotherapy. Most of information we have in the field of cardiac toxicity comes from studies utilizing real-world data (RWD) as randomized ...
Azadeh Abravan, Azadeh Abravan, Gareth Price, Gareth Price, Kathryn Banfill, Tom Marchant, Matthew Craddock, Matthew Craddock, Joe Wood, Marianne C. Aznar, Marianne C. Aznar, Alan McWilliam, Alan McWilliam, Marcel van Herk, Marcel van Herk, Corinne Faivre-Finn, Corinne Faivre-Finn   +16 more
doaj   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

SemantiPack: An Efficient Real-World Data Compressor Using Structural and Semantic Metadata

IEEE Access
The exponential growth of Real-World Data (RWD), primarily collected from IoT sensors and spanning domains such as mobility, environment, and energy consumption, presents critical challenges due to its scale, heterogeneity, and structural variability ...
Yoshiteru Nagata, Daiki Kohama, Yoshiki Watanabe, Shin Katayama, Kenta Urano, Takuro Yonezawa, Nobuo Kawaguchi   +6 more
doaj   +1 more source

Exploring the influential factors of roadway departure crashes on rural two-lane highways with logit model and association rules mining

International Journal of Transportation Science and Technology, 2021
Roadway departure (RwD) crashes are a major contributor of rural two-lane (R2L) highway crashes and fatalities. For targeted reduction of crashes and fatalities due to roadway departure, a thorough understanding of factors associated with RwD crashes is ...
M. Ashifur Rahman, Xiaoduan Sun, Subasish Das, Sushmita Khanal   +3 more
doaj   +1 more source

WebCat: RWD, dealing with navigation

Mosaic, 2013
El WebCat es el punto de encuentro entre profesionales del sector web (desarrolladores, diseñadores, emprendedores, etc.) abierto a cualquier persona interesada en esta parcela. Dentro de WebCat se abordan asuntos diversos, tanto de forma introductoria como especializada, mediante breves exposiciones de no más de quince minutos con el objetivo de ...
openaire   +1 more source