Results 91 to 100 of about 51,241 (200)

The Stern diatomic sequence via generalized Chebyshev polynomials

, 2015
Let a(n) be the Stern's diatomic sequence, and let x1,...,xr be the distances between successive 1's in the binary expansion of the (odd) positive integer n. We show that a(n) is obtained by evaluating generalized Chebyshev polynomials when the variables
De Angelis, Valerio
core  

Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies

MedComm, Volume 7, Issue 5, May 2026.
The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He, Sinan Xie, Kunlin Xie, Fengwei Gao, Yunshi Cai, Yan Huang, Chang Liu, Hong Wu, Yinghao Lyu, Tian Lan   +9 more
wiley   +1 more source

Therapeutic Potential of Retinoid X Receptor Modulators for the Treatment of the Metabolic Syndrome

PPAR Research, 2007
The increasing prevalence of obesity is a fundamental contributor to the growing prevalence of the metabolic syndrome. Rexinoids, a class of compounds that selectively bind and activate RXR, are being studied as a potential option for the treatment of ...
Jane A. Pinaire, Anne Reifel-Miller
doaj   +1 more source

LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1

Journal of Lipid Research, 2004
Abnormal HDL metabolism among patients with diabetes and insulin resistance may contribute to their increased risk of atherosclerosis. ATP binding cassette transporter A1 (ABCA1) mediates the transport of cholesterol and phospholipids from cells to HDL ...
Yutong Wang, Buran Kurdi-Haidar, John F. Oram   +2 more
doaj   +1 more source

Dexamethasone‐Mediated Regulation of CYP3A4 and UGTs in Human Hepatoma HuH‐7 Cells

Fundamental &Clinical Pharmacology, Volume 40, Issue 3, May 2026.
ABSTRACT Background The application of human hepatic cell lines to early drug discovery and development instead of human primary hepatocytes (HPHs) has been limited because of the low level of drug‐metabolizing enzymes (DMEs). Objective The study aimed to evaluate the effects of dexamethasone (DEX) treatment on DME expression, activities, and ...
Hana Yu, Song Hee Lee, Ji Hyeon Kim, Seung Jin Kim, Hee Eun Kang   +4 more
wiley   +1 more source

RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression

Nature Communications, 2020
Macrophages can differentiate to perform homeostatic tissue-specific functions. Here the authors show that RXR signalling is critical for large peritoneal macrophage (LPM) expansion during neonatal life and LPM lipid metabolism and survival during adult ...
María Casanova-Acebes, María Piedad Menéndez-Gutiérrez, Jesús Porcuna, Damiana Álvarez-Errico, Yonit Lavin, Ana García, Soma Kobayashi, Jessica Le Berichel, Vanessa Núñez, Felipe Were, Daniel Jiménez-Carretero, Fátima Sánchez-Cabo, Miriam Merad, Mercedes Ricote   +13 more
doaj   +1 more source

A Network Pharmacology and Experimental Validation Strategy for Hypoglycemic Study of Lonicerae Japonicae Flos on Diabetes

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT As diabetes has become an important public health issue, Lonicerae Japonicae Flos (LJF) had gradually attracted increasing attention on diabetes. This study aimed to investigate the hypoglycemic ingredients and underlying mechanisms of LJF in diabetes using an integrated strategy of network pharmacology, molecular docking and experimental ...
Zhang Nan, Liu Xiaolong, Li Chunyan, Ren Lu, Guo Chao, Xue Jintao   +5 more
wiley   +1 more source

Forsythiaside A alleviates acute lung injury by inhibiting inflammation and epithelial barrier damages in lung and colon through PPAR-γ/RXR-α complex

Journal of Advanced Research
Introduction: Acute lung injury (ALI) is a lung disease characterized by inflammation and still requires further drug development. Forsythiaside A as the active compound of Forsythiae Fructus has the therapeutic potential for ALI.
Jing Wang, Xinyan Xue, Xingtao Zhao, Lin Luo, Juan Liu, Shu Dai, Fang Zhang, Rui Wu, Yanfang Liu, Cheng Peng, Yunxia Li   +10 more
doaj   +1 more source

Activation of Retinoid X Receptor increases dopamine cell survival in models for Parkinson's disease

BMC Neuroscience, 2009
Background Parkinson's disease (PD) is caused by degeneration of dopamine (DA) neurons in the ventral midbrain (vMB) and results in severely disturbed regulation of movement. The disease inflicts considerable suffering for the affected and their families.
Bergsland Maria, Friling Stina, Kjellander Susanna   +2 more
doaj   +1 more source

Purification and Transcriptomic Characterization of Hypertrophied Hepatic Stellate Cells From CDAHFD Mouse Liver

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
The purification protocol for hypertrophied hepatic stellate cells (hypHSCs) developed in this study, using fibrotic and steatotic mouse livers (CDAHFD model), made it possible to obtain a high‐purity hypHSC preparation for transcriptomic analysis.
Marion Heckmann, Nour‐El‐Houda Djerir, Keola Greliche, Pierre‐Henri Commere, Julien Fernandes, Guillaume Sarrabayrouse, Bernard Hainque, Pascal Bigey, Virginie Escriou, Céline Hoffmann   +9 more
wiley   +1 more source