Biomolecules, 2021 Diabetic kidney is associated with an accumulation of extracellular matrix (ECM) leading to renal fibrosis. Dysregulation of retinoic acid metabolism involving retinoic acid receptors (RARs) and retinoid X receptors (RXRs) has been shown to play a ...
Subir Kumar Juin +2 more
doaj +1 more source
Magreceptorok működésének genomszintü vizsgálata kromatin immunprecipitációval primer humán immun sejtekben = Decoding nuclear hormone receptor activity using chromatin immunoprecipitation in human primary immune cells [PDF]
, 2012 A kutatómunka során szisztematikusan feltérképeztük az un RXR heterodimer típusú receptorok szerepét a humán monocita eredetű dendritikus sejtek differenciálódása és immunfunkciói során.
Barta, Endre +3 more
core
Retinoic Acid Signalling Regulates Zebrafish Tooth Germ Repair Following Injury
Cell Proliferation, EarlyView.Retinoic acid signalling may regulate the repair processes in a tooth germ injury model using Tg(scpp5:Dendra2‐NTR) zebrafish and the nitroreductase (NTR)/metronidazole (MTZ) system. ABSTRACT Although the role of retinoic acid (RA) signalling in odontogenesis is well established, its involvement in the repair of injured tooth germs remains unclear.
Qiqi Liu +4 more
wiley +1 more source
Retinoid X receptor heterodimers in hepatic function: structural insights and therapeutic potential
Frontiers in PharmacologyNuclear receptors (NRs) are key regulators of multiple physiological functions and pathological changes in the liver in response to a variety of extracellular signaling changes.
Renjie Xu +3 more
doaj +1 more source
Inhibition of lipopolysaccharide-induced gene expression by liver X receptor ligands in macrophages involves interference with early growth response factor 1 [PDF]
, 2015 © 2015 Elsevier Ltd. Liver X receptors (LXRs) are nuclear receptors that act as ligand-dependent transcription factors forming permissive heterodimers with retinoid X receptors (RXRs).
Guillem-Llobat, Paloma +1 more
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14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses
The Journal of Physiology, EarlyView.Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley +1 more source
LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells
Journal of Lipid Research, 2002 Regulation of gene expression of ATP-binding cassette transporter (ABC)A1 and ABCG1 by liver X receptor/retinoid X receptor (LXR/RXR) ligands was investigated in the human intestinal cell line CaCo-2.
Shubha Murthy +3 more
doaj +1 more source
Quantitative proteomics in resected renal cancer tissue for biomarker discovery and profiling [PDF]
, 2014 <b>Background:</b> Proteomics-based approaches for biomarker discovery are promising strategies used in cancer research. We present state-of-art label-free quantitative proteomics method to assess proteome of renal cell carcinoma (RCC ...
Atrih, A. +8 more
core +4 more sources
CellsThe active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D), binds to the vitamin D receptor (VDR) with high affinity. The VDR then heterodimerizes with the retinoid X receptor (RXR) and associates with vitamin D response elements (VDREs) to regulate ...
Mobin Emran Doost +6 more
doaj +1 more source
Journal of Applied Toxicology, Volume 46, Issue 6, Page 2003-2018, June 2026.ABSTRACT Humans are chronically exposed to mixtures of environmental contaminants. Exposure to endocrine‐disrupting chemicals (EDCs) contributes to increased health impairment observed globally. This study aimed to evaluate the endocrine‐disruptive and oxidative stress potential of a human‐relevant, complex chemical mixture in vitro.
Josefin Engelhardt +5 more
wiley +1 more source