Results 201 to 210 of about 2,684,234 (246)
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Cell Calcium, 2005
RyRs are large homotetrameric proteins that are approximately 4/5 cytoplasmic and approximately 1/5 transmembrane and luminal in mass. Mutations in RyRs produce human disease and many of these disease-causing mutations are in the cytoplasmic domains. To elucidate the mechanisms of a disease and to develop interventions, it is crucial to determine how ...
Stephan Lehnart +2 more
+6 more sources
RyRs are large homotetrameric proteins that are approximately 4/5 cytoplasmic and approximately 1/5 transmembrane and luminal in mass. Mutations in RyRs produce human disease and many of these disease-causing mutations are in the cytoplasmic domains. To elucidate the mechanisms of a disease and to develop interventions, it is crucial to determine how ...
Stephan Lehnart +2 more
+6 more sources
Diamide insecticides targeting insect ryanodine receptors: Mechanism and application prospect.
Biochemical and Biophysical Research Communications - BBRC, 2023As a Lepidoptera pest, Spodoptera frugiperda has become one of the major migratory pests causing significant damage to crops. It should prevent and control Spodoptera frugiperda with strong reproductive ability, adaptability, and migration ability, and ...
Juan Du, Yuejun Fu
semanticscholar +1 more source
Critical Reviews in Biochemistry and Molecular Biology, 1994
Recent findings on the ryanodine receptor of vertebrates, a Ca-release channel protein for the caffeine- and ryanodine-sensitive Ca pools, are reviewed in this article. Three distinct genes, i.e., ryr1, ryr2, and ryr3, express different isoforms in specific locations: Ryr1 in skeletal muscle and Purkinje cells of cerebellum; Ryr2 in cardiac muscle and ...
exaly +3 more sources
Recent findings on the ryanodine receptor of vertebrates, a Ca-release channel protein for the caffeine- and ryanodine-sensitive Ca pools, are reviewed in this article. Three distinct genes, i.e., ryr1, ryr2, and ryr3, express different isoforms in specific locations: Ryr1 in skeletal muscle and Purkinje cells of cerebellum; Ryr2 in cardiac muscle and ...
exaly +3 more sources
2023
The ryanodine receptor (RyR) is the largest known channel, named for specifically binding the alkaloid ryanodine. It is a homotetramer with high conductance for monovalent and divalent cations. Although not very Ca2+ selective, RyRs function as a Ca2+ release channel from the sarco/endoplasmic reticulum, amplifying the initial Ca2+ signaling from the ...
Benitah, Jean-Pierre +7 more
openaire +1 more source
The ryanodine receptor (RyR) is the largest known channel, named for specifically binding the alkaloid ryanodine. It is a homotetramer with high conductance for monovalent and divalent cations. Although not very Ca2+ selective, RyRs function as a Ca2+ release channel from the sarco/endoplasmic reticulum, amplifying the initial Ca2+ signaling from the ...
Benitah, Jean-Pierre +7 more
openaire +1 more source
Ryanodine receptor channelopathies
Biochemical and Biophysical Research Communications, 2004Ryanodine receptors (RyR) are the Ca2+ release channels of sarcoplasmic reticulum that provide the majority of the [Ca2+] necessary to induce contraction of cardiac and skeletal muscle cells. In their cellular environment, RyRs are exquisitely regulated by a variety of cytosolic factors and accessory proteins so that their output signal (Ca2+) induces ...
Nancy A, Benkusky +2 more
openaire +2 more sources
Muscling in on the ryanodine receptor
Nature Structural & Molecular Biology, 2015The ryanodine receptor (RyR), an ion channel regulating intracellular calcium release in excitable cells, has been challenging for structural analysis because of its colossal proportions compared to most other ion channels. Three independent groups have now used recent technological advancements in single-particle cryo-EM to make giant strides in ...
Ivana Y, Kuo, Barbara E, Ehrlich
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Structure and function of ryanodine receptors.
American Journal of Physiology-Cell Physiology, 1994Membrane depolarization, neurotransmitters, and hormones evoke a release of Ca2+ from intracellular Ca(2+)-storing organelles like the endoplasmic reticulum and, in muscle, the sarcoplasmic reticulum (SR). In turn, the released Ca2+ serves to trigger a variety of cellular responses.
Roberto Coron +3 more
semanticscholar +3 more sources
Ryanodine Receptor as Insecticide Target
Current Pharmaceutical Design, 2022: The ryanodine receptor (RyR) is one of the primary targets of commercial insecticides. The diamide insecticide family, including flubendiamide, chlorantraniliprole, cyantraniliprole, etc., targets insect RyRs and can be used to control a wide range of destructive agricultural pests.
Samurkas, Arthur +7 more
openaire +2 more sources
Ryanodine receptors as leak channels
European Journal of Pharmacology, 2014Ryanodine receptors are Ca(2+) release channels of internal stores. This review focuses on those situations and conditions that transform RyRs from a finely regulated ion channel to an unregulated Ca(2+) leak channel and the pathological consequences of this alteration.
Agustín, Guerrero-Hernández +2 more
openaire +2 more sources
Ryanodine receptors in smooth muscle
Frontiers in Bioscience, 2002The sarcoplasmic reticulum (SR) of smooth muscle is endowed with two different types of Ca2+ release channels, i.e. inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs). In general, both release channels mobilize Ca2+ from the same internal store in smooth muscle.
Agustín, Guerrero-Hernández +3 more
openaire +2 more sources