Results 31 to 40 of about 40,377 (99)

RTA-408 Protects Kidney from Ischemia-Reperfusion Injury in Mice via Activating Nrf2 and Downstream GSH Biosynthesis Gene

Oxidative Medicine and Cellular Longevity, 2017
Acute kidney injury (AKI) induced by ischemia-reperfusion is a critical conundrum in many clinical settings. Here, this study aimed to determine whether and how RTA-408, a novel oleanane triterpenoid, could confer protection against renal ischemia ...
P. Han, Zhiqiang Qin, Jingyuan Tang, Zhen Xu, Ran Li, Xuping Jiang, Chengdi Yang, Qian Xing, X. Qi, Min Tang, Jiexiu Zhang, B. Shen, Wei Wang, C. Qin, Wei Zhang   +14 more
semanticscholar   +1 more source

Maternal Vitamin B12 Status during Pregnancy and Early Infant Neurodevelopment: The ECLIPSES Study

Nutrients, 2023
In this prospective cohort study of 434 mother–infant pairs from the ECLIPSES study, we examine the association between maternal vitamin B12 status at the beginning and end of pregnancy and the neurodevelopmental outcomes of infants 40 days after birth ...
Josué Cruz-Rodríguez, A. Díaz-López, J. Canals-Sans, V. Arija   +3 more
semanticscholar   +1 more source

Polydipsia as a manifestation of catatonia: Case series

Journal of Affective Disorders Reports, 2021
Introduction: Psychogenic polydipsia, a diagnosis of exclusion, is prevalent among patients with psychiatric disorders. Polydipsia has been associated with catatonia without clear causation or directionality.
Thomas Laux, Yassir Mahgoub, Jatinder Singh, Andrew Francis   +3 more
doaj  

The problem with communication stress from face masks

Journal of Affective Disorders Reports, 2021
/Summary: Objective: Widely present pandemic-related stress resulting from the use of face masks needs definition, evaluation and treatment. Mouth coverings hamper communication, increasing stress that possibly compromises the immune system and ...
Daniel M. Campagne
doaj  

RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity

PLoS ONE, 2015
Semi-synthetic triterpenoids are antioxidant inflammation modulator (AIM) compounds that inhibit tumor cell growth and metastasis. Compounds in the AIM class bind to Keap1 and attenuate Nrf2 degradation.
B. Probst, Isaac Treviño, Lyndsey McCauley, R. Bumeister, I. Dulubova, W. Wigley, D. Ferguson   +6 more
semanticscholar   +1 more source

408 Cases of Genital Ambiguity Followed by Single Multidisciplinary Team during 23 Years: Etiologic Diagnosis and Sex of Rearing

International Journal of Endocrinology, 2016
Objective. To evaluate diagnosis, age of referral, karyotype, and sex of rearing of cases with disorders of sex development (DSD) with ambiguous genitalia. Methods. Retrospective study during 23 years at outpatient clinic of a referral center.
Georgette Beatriz De Paula, B. A. Barros, Stela Carpini, Bruna J Tincani, T. N. Mazzola, Mara Sanches Guaragna, C. S. C. Piveta, L. C. de Oliveira, J. Andrade, Guilherme Guaragna-Filho, Pedro Perez Barbieri, Nathalia Montibeler Ferreira, M. Miranda, E. Gonçalves, A. Morcillo, N. Viguetti-Campos, S. Lemos-Marini, R. B. D. P. Silva, A. P. Marques-de-Faria, M. de Mello, A. Maciel-Guerra, G. Guerra‐Júnior   +21 more
semanticscholar   +1 more source

Search of brain-enriched proteins in salivary extracellular vesicles for their use as mental disease biomarkers: A pilot study of the neuronal glycoprotein M6a

Journal of Affective Disorders Reports, 2020
Background: Mental disorders affect millions of people worldwide. Their etiology is complex and the fact that the main effects occur in the brain hampers biochemical diagnosis.
Melisa C. Monteleone, Silvia C. Billi, Luciano Viale, Natalia P. Catoira, Alberto C. Frasch, Marcela A. Brocco   +5 more
doaj  

Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors

OncoTargets and Therapy, 2017
Background Omaveloxolone is a semisynthetic oleanane triterpenoid that potently activates Nrf2 with subsequent antioxidant function. We conducted a first-in-human Phase I clinical trial (NCT02029729) with the primary objectives to determine the ...
B. Creelan, D. Gabrilovich, J. Gray, Charles C. Williams, T. Tanvetyanon, E. Haura, J. Weber, G. Gibney, J. Markowitz, J. Proksch, S. Reisman, M. McKee, M. Chin, C. Meyer, S. Antonia   +14 more
semanticscholar   +1 more source

MovieQA: Understanding Stories in Movies through Question-Answering [PDF]

Computer Vision and Pattern Recognition, 2015
We introduce the MovieQA dataset which aims to evaluate automatic story comprehension from both video and text. The dataset consists of 14,944 questions about 408 movies with high semantic diversity.
Makarand Tapaswi, Yukun Zhu, R. Stiefelhagen, A. Torralba, R. Urtasun, S. Fidler   +5 more
semanticscholar   +1 more source

Reduced heart rate variability is associated with vulnerability to depression

Journal of Affective Disorders Reports, 2020
Background: Heart rate variability (HRV) mirrors cardiac autonomic modulation, an index of well-being. Reduced HRV has been reported in depression, but few studies investigated HRV in individuals at-risk of or remitted from a full-blown depressive ...
Carola Dell’Acqua, Elisa Dal Bò, Simone Messerotti Benvenuti, Daniela Palomba   +3 more
doaj