Results 181 to 190 of about 3,075,213 (194)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Prediction of pre- and postfusion conformations of class I fusion proteins with AlphaFold2. [PDF]

PLoS One
Gülesen S, Most V, Schoeder CT, Meiler J.   +3 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Sequence Types of <i>Cryptococcus neoformans</i> and Their Associations with Clinical Characteristics and Outcomes of AIDS Patients with Cryptococcal Meningitis in Southern China. [PDF]

Pathogens
Li C, Zhang Y, Ke Y, Zhang Y, Chen M, Tao X, Guo P, Chen J, Tang X, Lin W, Li L.   +10 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Searching for sequence features that control DNA cyclizability. [PDF]

PNAS Nexus
Gordiychuk M, Park J, Basu A, Ha T, Bialek W, Zhang Y.   +5 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Large-scale statistical dissection of sequence-derived biochemical features distinguishing soluble and insoluble proteins. [PDF]

PLoS One
Vu NHH, Nguyen BL.
europepmc   +1 more source

ViralMultiNet: A structure-aware multimodal framework for viral protein function prediction in wastewater surveillance. [PDF]

PLoS One
Liu F, Lai T, Xu W, Li G.
europepmc   +1 more source

Heuristic multi-site optimization for protein sequence design using Masked Protein Language Models. [PDF]

PLoS Comput Biol
Wang L, Wang Y, Qiu C, Xiao L, Liu X, Chen J.   +5 more
europepmc   +1 more source